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Current Osteoporosis Reports

Erschienen in:

15.05.2019 | Skeletal Biology and Regulation (M Forwood and A Robling, Section Editors)

RNA-seq in Skeletal Biology

verfasst von: Ugur Ayturk

Erschienen in: Current Osteoporosis Reports | Ausgabe 4/2019

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Abstract

Purpose of Review

The goal of this paper is to review state-of-the-art transcriptome profiling methods and their recent applications in the field of skeletal biology.

Recent Findings

Next-generation sequencing of mRNA (RNA-seq) methods have been established and routinely used in skeletal biology research. RNA-seq has led to the identification of novel genes and transcription factors involved in skeletal development and disease, through its application in small and large animal models, as well as human tissue and cells. With the availability of advanced techniques such as single-cell RNA-seq, novel cell types in skeletal tissues are being identified.

Summary

As the sequencing technologies are rapidly evolving, the exciting discoveries supported by transcriptomics will continue to emerge and improve our understanding of the biology of the skeleton.

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Titel: RNA-seq in Skeletal Biology
verfasst von: Ugur Ayturk
Publikationsdatum: 15.05.2019
Verlag: Springer US
Erschienen in: Current Osteoporosis Reports / Ausgabe 4/2019
Print ISSN: 1544-1873
Elektronische ISSN: 1544-2241
DOI: https://doi.org/10.1007/s11914-019-00517-x

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RNA-seq in Skeletal Biology

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Recent Findings

Summary

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