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European Journal of Clinical Microbiology & Infectious Diseases

Erschienen in:

16.04.2021 | Brief Report

Role of asymptomatic bacteriuria on early periprosthetic joint infection after hip hemiarthroplasty. BARIFER randomized clinical trial

verfasst von: Dolors Rodríguez-Pardo, María Dolores del Toro, Laura Guío-Carrión, Rosa Escudero-Sánchez, Marta Fernández-Sampedro, Miguel Ángel García-Viejo, María Velasco-Arribas, Laura Soldevila-Boixader, Magdalena Femenias, José Antonio Iribarren, María del Carmen Pulido-Garcia, María Dolores Navarro, Mayli Lung, Pablo S. Corona, Benito Almirante, Carles Pigrau

Erschienen in: European Journal of Clinical Microbiology & Infectious Diseases | Ausgabe 11/2021

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Abstract

Purpose

To evaluate preoperative asymptomatic bacteriuria (ASB) treatment to reduce early-periprosthetic joint infections (early-PJIs) after hip hemiarthroplasty (HHA) for fracture.

Methods

Open-label, multicenter RCT comparing fosfomycin-trometamol versus no intervention with a parallel follow-up cohort without ASB. Primary outcome: early-PJI after HHA.

Results

Five hundred ninety-four patients enrolled (mean age 84.3); 152(25%) with ASB (77 treated with fosfomycin-trometamol/75 controls) and 442(75%) without. Despite the study closed without the intended sample size, ASB was not predictive of early-PJI (OR: 1.06 [95%CI: 0.33–3.38]), and its treatment did not modify early-PJI incidence (OR: 1.03 [95%CI: 0.15–7.10]).

Conclusions

Neither preoperative ASB nor its treatment appears to be risk factors of early-PJI after HHA. ClinicalTrials.gov Identifier: Eudra CT 2016-001108-47

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Titel: Role of asymptomatic bacteriuria on early periprosthetic joint infection after hip hemiarthroplasty. BARIFER randomized clinical trial
verfasst von: Dolors Rodríguez-Pardo
María Dolores del Toro
Laura Guío-Carrión
Rosa Escudero-Sánchez
Marta Fernández-Sampedro
Miguel Ángel García-Viejo
María Velasco-Arribas
Laura Soldevila-Boixader
Magdalena Femenias
José Antonio Iribarren
María del Carmen Pulido-Garcia
María Dolores Navarro
Mayli Lung
Pablo S. Corona
Benito Almirante
Carles Pigrau
Publikationsdatum: 16.04.2021
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Clinical Microbiology & Infectious Diseases / Ausgabe 11/2021
Print ISSN: 0934-9723
Elektronische ISSN: 1435-4373
DOI: https://doi.org/10.1007/s10096-021-04241-2

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Role of asymptomatic bacteriuria on early periprosthetic joint infection after hip hemiarthroplasty. BARIFER randomized clinical trial

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