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Journal of Cancer Research and Clinical Oncology

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07.08.2017 | Review – Cancer Research

Role of autophagy in regulating the radiosensitivity of tumor cells

verfasst von: Yong Xin, Fan Jiang, Chunsheng Yang, Qiuyue Yan, Wenwen Guo, Qian Huang, Longzhen Zhang, Guan Jiang

Erschienen in: Journal of Cancer Research and Clinical Oncology | Ausgabe 11/2017

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Abstract

Background

Autophagy is a metabolic response of cells to chemical and physical factors, such as nutrition or growth factor deprivation, proinflammatory state, hypoxia, accumulation of reactive oxygen species, presence of infectious agents, and DNA damage. Autophagy maintains the homeostasis of intracellular metabolism mainly by degrading cellular organelles and critical proteins. In a sense, autophagy protects cells from death. Radiotherapy is a powerful tool used to control tumor growth, and it can induce autophagy. The relationship between radiotherapy and autophagy is worthy of further investigation.

Methods

We searched various electronic databases including PubMed for peer-reviewed English-language articles and selected articles on the mechanism of autophagy, its role in cancer development and cancer treatment, and the relationship between the effect of radiation therapy and autophagy intensity.

Results

This review has recently shown that the sensitivity of tumor cells to radiation therapy can be increased by regulating autophagy.

Conclusion

The effects of autophagy vary, and autophagy provides various ways of enhancing radiosensitivity, including inhibition of autophagy, increase in autophagy, and altering the outcome of autophagy.

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Titel: Role of autophagy in regulating the radiosensitivity of tumor cells
verfasst von: Yong Xin
Fan Jiang
Chunsheng Yang
Qiuyue Yan
Wenwen Guo
Qian Huang
Longzhen Zhang
Guan Jiang
Publikationsdatum: 07.08.2017
Verlag: Springer Berlin Heidelberg
Erschienen in: Journal of Cancer Research and Clinical Oncology / Ausgabe 11/2017
Print ISSN: 0171-5216
Elektronische ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-017-2487-2

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Role of autophagy in regulating the radiosensitivity of tumor cells

Abstract

Background

Methods

Results

Conclusion

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Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Background

Methods

Results

Conclusion

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