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01.06.2016 | Original Research Paper

Role of capsaicin-sensitive nerves and tachykinins in mast cell tryptase-induced inflammation of murine knees

verfasst von: Éva Borbély, Katalin Sándor, Adrienn Markovics, Ágnes Kemény, Erika Pintér, János Szolcsányi, John P. Quinn, Jason J. McDougall, Zsuzsanna Helyes

Erschienen in: Inflammation Research | Ausgabe 9/2016

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Abstract

Objective, design

Mast cell tryptase (MCT) is elevated in arthritic joints, but its direct effects are not known. Here, we investigated MCT-evoked acute inflammatory and nociceptive mechanisms with behavioural, in vivo imaging and immunological techniques.

Material and subjects

Neurogenic inflammation involving capsaicin-sensitive afferents, transient receptor potential vanilloid 1 receptor (TRPV1), substance P (SP), neurokinin A (NKA) and their NK1 tachykinin receptor were studied using gene-deleted mice compared to C57Bl/6 wildtypes (n = 5–8/group).

Treatment

MCT was administered intraarticularly or topically (20 μl, 12 μg/ml). Capsaicin-sensitive afferents were defunctionalized with the TRPV1 agonist resiniferatoxin (RTX; 30–70–100 μg/kg s.c. pretreatment).

Methods

Knee diameter was measured with a caliper, synovial perfusion with laser Doppler imaging, mechanonociception with aesthesiometry and weight distribution with incapacitance tester over 6 h. Cytokines and neuropeptides were determined with immunoassays.

Results

MCT induced synovial vasodilatation, oedema, impaired weight distribution and mechanical hyperalgesia, but cytokine or neuropeptide levels were not altered at the 6-h timepoint. Hyperaemia was reduced in RTX-treated and TRPV1-deleted animals, and oedema was absent in NK1-deficient mice. Hyperalgesia was decreased in SP/NKA- and NK1-deficient mice, weight bearing impairment in RTX-pretreated, TRPV1- and NK1-deficient animals.

Conclusions

MCT evokes synovial hyperaemia, oedema, hyperalgesia and spontaneous pain. Capsaicin-sensitive afferents and TRPV1 receptors are essential for vasodilatation, while tachykinins mediate oedema and pain.

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Titel: Role of capsaicin-sensitive nerves and tachykinins in mast cell tryptase-induced inflammation of murine knees
verfasst von: Éva Borbély
Katalin Sándor
Adrienn Markovics
Ágnes Kemény
Erika Pintér
János Szolcsányi
John P. Quinn
Jason J. McDougall
Zsuzsanna Helyes
Publikationsdatum: 01.06.2016
Verlag: Springer International Publishing
Erschienen in: Inflammation Research / Ausgabe 9/2016
Print ISSN: 1023-3830
Elektronische ISSN: 1420-908X
DOI: https://doi.org/10.1007/s00011-016-0954-x

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Role of capsaicin-sensitive nerves and tachykinins in mast cell tryptase-induced inflammation of murine knees

Abstract

Objective, design

Material and subjects

Treatment

Methods

Results

Conclusions

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Parodontalbehandlung verbessert Prognose bei Katheterablation

Antihypertensiva schützen auch alte Menschen noch vor Demenz

Stereotaktische Radiatio schlägt konventionelle Bestrahlung

Denken Sie bei starker Blutung auch an die Hemmkörper-Hämophilie

Update Innere Medizin

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

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Abstract

Objective, design

Material and subjects

Treatment

Methods

Results

Conclusions

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