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Erschienen in: Heart and Vessels 9/2020

04.04.2020 | Original Article

Role of dipstick proteinuria for predicting cardiovascular events: a Japanese cardiovascular hospital database analysis

verfasst von: Riku Arai, Shinya Suzuki, Hiroto Kano, Hiroaki Semba, Takuto Arita, Naoharu Yagi, Takayuki Otsuka, Shunsuke Matsuno, Minoru Matsuhama, Yuko Kato, Tokuhisa Uejima, Yuji Oikawa, Yasuo Okumura, Junji Yajima, Takeshi Yamashita

Erschienen in: Heart and Vessels | Ausgabe 9/2020

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Abstract

Initial screening for proteinuria by urine dipstick test (UDT) may be useful for predicting clinical outcomes. The Shinken Database includes all the new patients visiting the Cardiovascular Institute Hospital in Tokyo, Japan. Patients for whom UDT was performed at their initial visit between 2004 and 2010 (n = 7131) were divided into three groups according to the test results: negative, trace, and positive (1+ to 4+) proteinuria. During the mean follow-up period of 3.4 years, 233 (3.1%) deaths, 255 (3.6%) heart failure (HF) events, and 106 (1.5%) ischemic stroke (IS) events occurred. Prevalence of atherothrombotic risks increased with an increase in the amounts of proteinuria. The incidence of all-cause death, HF and IS events increased significantly from negative to trace to positive proteinuria groups (log rank test, P for trend < 0.001). Multivariate analysis revealed independent association between proteinuria and all-cause death [hazard ratio (HR): 1.50, 95% confidence interval (CI) 1.07–2.10], HF (HR: 1.55, 95% CI 1.14–2.12), and IS (HR: 2.08, 95% CI 1.26–3.45). Even trace proteinuria was independently associated with HF (HR: 1.64, 95% CI 1.07–2.53) and IS (HR: 2.17, 95% CI 1.14–4.11) and with all-cause death (HR: 1.56, 95% CI 0.99–2.47). In conclusions, dipstick proteinuria was independently associated with cardiovascular events and death, suggesting that the UDT is a useful tool for evaluating patients’ risk for such adverse events.
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Metadaten
Titel
Role of dipstick proteinuria for predicting cardiovascular events: a Japanese cardiovascular hospital database analysis
verfasst von
Riku Arai
Shinya Suzuki
Hiroto Kano
Hiroaki Semba
Takuto Arita
Naoharu Yagi
Takayuki Otsuka
Shunsuke Matsuno
Minoru Matsuhama
Yuko Kato
Tokuhisa Uejima
Yuji Oikawa
Yasuo Okumura
Junji Yajima
Takeshi Yamashita
Publikationsdatum
04.04.2020
Verlag
Springer Japan
Erschienen in
Heart and Vessels / Ausgabe 9/2020
Print ISSN: 0910-8327
Elektronische ISSN: 1615-2573
DOI
https://doi.org/10.1007/s00380-020-01596-y

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