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Current Allergy and Asthma Reports
Erschienen in: Current Allergy and Asthma Reports 9/2020

01.09.2020 | Allergies and the Environment (T Moran, Section Editor)

Role of Environmental Adjuvants in Asthma Development

verfasst von: Donald N. Cook

Erschienen in: Current Allergy and Asthma Reports | Ausgabe 9/2020

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Abstract

Purpose of Review

This review summarizes recent progress in our understanding how environmental adjuvants promote the development of asthma.

Recent Findings

Asthma is a heterogeneous set of lung pathologies with overlapping features. Human studies and animal models suggest that exposure to different environmental adjuvants activate distinct immune pathways, which in turn give rise to distinct forms, or endotypes, of allergic asthma. Depending on their concentrations, inhaled TLR ligands can activate either type 2 inflammation, or Th17 differentiation, along with regulatory responses that function to attenuate inflammation. By contrast, a different category of environmental adjuvants, proteases, activate distinct immune pathways and prime predominantly type 2 immune responses.

Summary

Asthma is not a single disease, but rather a group of pathologies with overlapping features. Different endotypes of asthma likely arise from perturbations of distinct immunologic pathways during allergic sensitization.
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Metadaten
Titel
Role of Environmental Adjuvants in Asthma Development
verfasst von
Donald N. Cook
Publikationsdatum
01.09.2020
Verlag
Springer US
Erschienen in
Current Allergy and Asthma Reports / Ausgabe 9/2020
Print ISSN: 1529-7322
Elektronische ISSN: 1534-6315
DOI
https://doi.org/10.1007/s11882-020-00935-3

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