The online version of this article (doi:10.1186/1476-9255-9-23) contains supplementary material, which is available to authorized users.
The authors declare that they have no competing interests.
RCV and VMBA conceived of the review, designed, and wrote the manuscript. ABP, JJVA, MCJ and BBF contributed to critical reading and comments of the manuscript. All authors read and approved of the final manuscript.
Glycogen synthase kinase 3β (GSK3β) plays a fundamental role during the inflammatory response induced by bacteria. Depending on the pathogen and its virulence factors, the type of cell and probably the context in which the interaction between host cells and bacteria takes place, GSK3β may promote or inhibit inflammation. The goal of this review is to discuss recent findings on the role of the inhibition or activation of GSK3β and its modulation of the inflammatory signaling in monocytes/macrophages and epithelial cells at the transcriptional level, mainly through the regulation of nuclear factor-kappaB (NF-κB) activity. Also included is a brief overview on the importance of GSK3 in non-inflammatory processes during bacterial infection.
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- Role of glycogen synthase kinase-3 beta in the inflammatory response caused by bacterial pathogens
Juan J Valdez-Alarcón
Marcos Cajero Juárez
B Brett Finlay
Víctor M Baizabal-Aguirre
- BioMed Central
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