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30.04.2020 | Review Article

Role of long non-coding RNAs (LncRNAs) in multiple sclerosis: a brief review

verfasst von: Eskandar Taghizadeh, Forough Taheri, Mohammad Mahdi Samadian, Mohammad Soudyab, Abbas Abi, Seyed Mohammad Gheibi hayat

Erschienen in: Neurological Sciences | Ausgabe 9/2020

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Abstract

Multiple sclerosis (MS) as chronic autoimmune inflammatory neurological disease of the central nervous system (CNS) occurs due to several environmental and genetic factors, whose pathogenesis is associated with genes with regulatory role in the immune system. Long non-coding RNAs (LncRNAs) are able to reportedly regulate responses of immune systems and expression of genes, and show the tissue specificity and complexity of biofunctions. Various studies have suggested that the aberrant LncRNA expression is an underlying factor involved in the incidence of MS and that the analysis of the expression profile of these molecules can be a specific biomarker of MS for preventing the course of the disease or responding to treatment. The purpose of this research was to review the recent studies for exploring the functions of LncRNAs in the processes leading to MS disease.

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Titel: Role of long non-coding RNAs (LncRNAs) in multiple sclerosis: a brief review
verfasst von: Eskandar Taghizadeh
Forough Taheri
Mohammad Mahdi Samadian
Mohammad Soudyab
Abbas Abi
Seyed Mohammad Gheibi hayat
Publikationsdatum: 30.04.2020
Verlag: Springer International Publishing
Erschienen in: Neurological Sciences / Ausgabe 9/2020
Print ISSN: 1590-1874
Elektronische ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-020-04425-2

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Role of long non-coding RNAs (LncRNAs) in multiple sclerosis: a brief review

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