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Current Osteoporosis Reports

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16.03.2018 | Bone Marrow and Adipose Tissue (G Duque and B Lecka-Czernik, Section Editors)

Role of Marrow Adipocytes in Regulation of Energy Metabolism and Bone Homeostasis

verfasst von: Jillian Cornish, Tao Wang, Jian-ming Lin

Erschienen in: Current Osteoporosis Reports | Ausgabe 2/2018

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Abstract

Purpose of review

The goal of this review is to gain a better understanding of marrow adipocyte development, its regulation of energy, and its characterization responsible for bone homeostasis.

Recent findings

Despite major advances in uncovering the complex association of bone-fat in the marrow, the underlying basic biological process of adipose tissue development, as well as its interaction with bone homeostasis in pathophysiological conditions, is still not well understood.

Summary

This review identifies many pro- and anti-osteogenic factors secreted by adipocytes to play a role in the manipulating the fate of mesenchymal stem cells as well as the osteoblastic activity during bone remodeling. It also addresses the function of adipose tissue capable of negative regulation of the hematopoietic microenvironment to influence the bone quantity and the nature of bone homeostasis.

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Titel: Role of Marrow Adipocytes in Regulation of Energy Metabolism and Bone Homeostasis
verfasst von: Jillian Cornish
Tao Wang
Jian-ming Lin
Publikationsdatum: 16.03.2018
Verlag: Springer US
Erschienen in: Current Osteoporosis Reports / Ausgabe 2/2018
Print ISSN: 1544-1873
Elektronische ISSN: 1544-2241
DOI: https://doi.org/10.1007/s11914-018-0425-0

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Role of Marrow Adipocytes in Regulation of Energy Metabolism and Bone Homeostasis

Abstract

Purpose of review

Recent findings

Summary

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Recent findings

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