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International Orthopaedics
Erschienen in: International Orthopaedics 12/2013

01.12.2013 | Review Article

Role of mesenchymal stem cells in bone regeneration and fracture repair: a review

verfasst von: Xin Wang, Yu Wang, Wenlong Gou, Qiang Lu, Jiang Peng, Shibi Lu

Erschienen in: International Orthopaedics | Ausgabe 12/2013

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Abstract

Mesenchymal stem cells (MSCs) are non-haematopoietic stromal stem cells that have many sources, such as bone marrow, periosteum, vessel walls, adipose, muscle, tendon, peripheral circulation, umbilical cord blood, skin and dental tissues. They are capable of self-replication and of differentiating into, and contributing to the regeneration of, mesenchymal tissues, such as bone, cartilage, ligament, tendon, muscle and adipose tissue. The homing of MSCs may play an important role in the repair of bone fractures. As a composite material, the formation and growth of bone tissue is a complex process, including molecular, cell and biochemical metabolic changes. The recruitment of factors with an adequate number of MSCs and the micro-environment around the fracture are effective for fracture repair. Several studies have investigated the functional expression of various chemokine receptors, trophic factors and adhesion molecules in human MSCs. Many external factors affect MSC homing. MSCs have been used as seed cells in building tissue-engineered bone grafts. Scaffolds seeded with MSCs are most often used in tissue engineering and include biotic and abiotic materials. This knowledge provides a platform for the development of novel therapies for bone regeneration with endogenous MSCs.
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Metadaten
Titel
Role of mesenchymal stem cells in bone regeneration and fracture repair: a review
verfasst von
Xin Wang
Yu Wang
Wenlong Gou
Qiang Lu
Jiang Peng
Shibi Lu
Publikationsdatum
01.12.2013
Verlag
Springer Berlin Heidelberg
Erschienen in
International Orthopaedics / Ausgabe 12/2013
Print ISSN: 0341-2695
Elektronische ISSN: 1432-5195
DOI
https://doi.org/10.1007/s00264-013-2059-2

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