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Erschienen in: Current Nutrition Reports 2/2017

29.04.2017 | Nutrition and Aging (MC Serra, Section Editor)

Role of Nutrition to Promote Healthy Brain Aging and Reduce Risk of Alzheimer’s Disease

verfasst von: Michelle Walters, Katherine Hackett, Emily Caesar, Richard Isaacson, Lisa Mosconi

Erschienen in: Current Nutrition Reports | Ausgabe 2/2017

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Abstract

Purpose of Review

Alzheimer’s disease (AD) is the most common form of dementia worldwide, with the disease burden expected to rise as the population ages.

Recent Findings

No pharmacological therapy is currently available to cure or prevent AD. Nonetheless, recent research suggests that nutritional and lifestyle modifications might help delay or even prevent the onset of AD, especially when instituted prior to substantial neuronal loss.

Summary

This article reviews proposed nutritional interventions for AD prevention that focus on adopting dietary patterns and improvement of macro- and micronutrient distribution or intakes, improvement of insulin resistance, correction of dyslipidemia, and reduction of oxidative stress.
Literatur
1.
Zurück zum Zitat Brookmeyer R, Evans DA, Hebert L, Langa KM, Heeringa SG, Plassman BL, et al. National estimates of the prevalence of Alzheimer’s disease in the United States. Alzheimers Dement. 2011;7:61–73.CrossRefPubMedPubMedCentral Brookmeyer R, Evans DA, Hebert L, Langa KM, Heeringa SG, Plassman BL, et al. National estimates of the prevalence of Alzheimer’s disease in the United States. Alzheimers Dement. 2011;7:61–73.CrossRefPubMedPubMedCentral
2.
Zurück zum Zitat Walsh DM, Selkoe DJ. A critical appraisal of the pathogenic protein spread hypothesis of neurodegeneration. Nat Rev Neurosci. 2016;17(4):251–60.CrossRefPubMed Walsh DM, Selkoe DJ. A critical appraisal of the pathogenic protein spread hypothesis of neurodegeneration. Nat Rev Neurosci. 2016;17(4):251–60.CrossRefPubMed
3.
Zurück zum Zitat Carrillo MC, Dean RA, Nicolas F, Miller DS, Berman R, Khachaturian Z, et al. Revisiting the framework of the National Institute on Aging-Alzheimer’s Association diagnostic criteria. Alzheimers Dement. 2013;9:594–601.CrossRefPubMed Carrillo MC, Dean RA, Nicolas F, Miller DS, Berman R, Khachaturian Z, et al. Revisiting the framework of the National Institute on Aging-Alzheimer’s Association diagnostic criteria. Alzheimers Dement. 2013;9:594–601.CrossRefPubMed
4.
Zurück zum Zitat Sperling R, Mormino E, Johnson K. The evolution of preclinical Alzheimer’s disease: implications for prevention trials. Neuron. 2014;84(3):608–22.CrossRefPubMedPubMedCentral Sperling R, Mormino E, Johnson K. The evolution of preclinical Alzheimer’s disease: implications for prevention trials. Neuron. 2014;84(3):608–22.CrossRefPubMedPubMedCentral
5.
Zurück zum Zitat Bertram L, Tanzi RE. Thirty years of Alzheimer’s disease genetics: the implications of systematic meta-analyses. Nat Rev Neurosci. 2008;9(10):768–78.CrossRefPubMed Bertram L, Tanzi RE. Thirty years of Alzheimer’s disease genetics: the implications of systematic meta-analyses. Nat Rev Neurosci. 2008;9(10):768–78.CrossRefPubMed
7.
Zurück zum Zitat Willett WC, Sacks F, Trichopoulou A, Drescher G, Ferro-Luzzi A, Helsing E, et al. Mediterranean diet pyramid: a cultural model for healthy eating. Am J Clin Nutr. 1995;61(6 Suppl):1402S–6S.PubMed Willett WC, Sacks F, Trichopoulou A, Drescher G, Ferro-Luzzi A, Helsing E, et al. Mediterranean diet pyramid: a cultural model for healthy eating. Am J Clin Nutr. 1995;61(6 Suppl):1402S–6S.PubMed
8.
Zurück zum Zitat Féart C, Samieri C, Rondeau V, Amieva H, Portet F, Dartigues JF, et al. Adherence to a Mediterranean diet, cognitive decline, and risk of dementia. JAMA. 2009;302(6):638–48.CrossRefPubMedPubMedCentral Féart C, Samieri C, Rondeau V, Amieva H, Portet F, Dartigues JF, et al. Adherence to a Mediterranean diet, cognitive decline, and risk of dementia. JAMA. 2009;302(6):638–48.CrossRefPubMedPubMedCentral
9.
Zurück zum Zitat Tangney CC, Kwasny MJ, Li H, Wilson RS, Evans DA, Morris MC. Adherence to a Mediterranean-type dietary pattern and cognitive decline in a community population. Am J Clin Nutr. 2011;93(3):601–7.CrossRefPubMed Tangney CC, Kwasny MJ, Li H, Wilson RS, Evans DA, Morris MC. Adherence to a Mediterranean-type dietary pattern and cognitive decline in a community population. Am J Clin Nutr. 2011;93(3):601–7.CrossRefPubMed
10.
Zurück zum Zitat Wengreen H, Munger RG, Cutler A, Quach A, Bowles A, Corcoran C, et al. Prospective study of dietary approaches to stop hypertension- and Mediterranean-style dietary patterns and age-related cognitive change: the Cache County Study on Memory, Health and Aging. Am J Clin Nutr. 2013;98(5):1263–71.CrossRefPubMedPubMedCentral Wengreen H, Munger RG, Cutler A, Quach A, Bowles A, Corcoran C, et al. Prospective study of dietary approaches to stop hypertension- and Mediterranean-style dietary patterns and age-related cognitive change: the Cache County Study on Memory, Health and Aging. Am J Clin Nutr. 2013;98(5):1263–71.CrossRefPubMedPubMedCentral
11.
Zurück zum Zitat Tangney CC, Li H, Wang Y, Barnes L, Schneider JA, Bennett DA, et al. Relation of DASH- and Mediterranean-like dietary patterns to cognitive decline in older persons. Neurology. 2014;83(16):1410–6.CrossRefPubMedPubMedCentral Tangney CC, Li H, Wang Y, Barnes L, Schneider JA, Bennett DA, et al. Relation of DASH- and Mediterranean-like dietary patterns to cognitive decline in older persons. Neurology. 2014;83(16):1410–6.CrossRefPubMedPubMedCentral
12.
Zurück zum Zitat Trichopoulou A, Kyrozis A, Rossi M, Katsoulis M, Trichopoulos D, La Vecchia C, et al. Mediterranean diet and cognitive decline over time in an elderly Mediterranean population. Eur J Nutr. 2015;54(8):1311–21.CrossRefPubMed Trichopoulou A, Kyrozis A, Rossi M, Katsoulis M, Trichopoulos D, La Vecchia C, et al. Mediterranean diet and cognitive decline over time in an elderly Mediterranean population. Eur J Nutr. 2015;54(8):1311–21.CrossRefPubMed
13.
14.
Zurück zum Zitat Scarmeas N, Stern Y, Mayeux R, Manly JJ, Schupf N, Luchsinger JA. Mediterranean diet and mild cognitive impairment. Arch Neurol. 2009;66(2):216–25.CrossRefPubMedPubMedCentral Scarmeas N, Stern Y, Mayeux R, Manly JJ, Schupf N, Luchsinger JA. Mediterranean diet and mild cognitive impairment. Arch Neurol. 2009;66(2):216–25.CrossRefPubMedPubMedCentral
15.
Zurück zum Zitat Morris MC, Tangney CC, Wang Y, Sacks FM, Bennett DA, Aggarwal NT. MIND diet associated with reduced incidence of Alzheimer’s disease. Alzheimers Dement. 2015;11(9):1007–14.CrossRefPubMedPubMedCentral Morris MC, Tangney CC, Wang Y, Sacks FM, Bennett DA, Aggarwal NT. MIND diet associated with reduced incidence of Alzheimer’s disease. Alzheimers Dement. 2015;11(9):1007–14.CrossRefPubMedPubMedCentral
16.
Zurück zum Zitat Gu Y, Luchsinger JA, Stern Y, Scarmeas N. Mediterranean diet, inflammatory and metabolic biomarkers, and risk of Alzheimer’s disease. J Alzheimers Dis. 2010;22(2):483–92.CrossRefPubMedPubMedCentral Gu Y, Luchsinger JA, Stern Y, Scarmeas N. Mediterranean diet, inflammatory and metabolic biomarkers, and risk of Alzheimer’s disease. J Alzheimers Dis. 2010;22(2):483–92.CrossRefPubMedPubMedCentral
17.
Zurück zum Zitat Cao L, Tan L, Wang HF, Jiang T, Zhu XC, Lu H, et al. Dietary patterns and risk of dementia: a systematic review and meta-analysis of cohort studies. Mol Neurobiol. 2016;53(9):6144–54.CrossRefPubMed Cao L, Tan L, Wang HF, Jiang T, Zhu XC, Lu H, et al. Dietary patterns and risk of dementia: a systematic review and meta-analysis of cohort studies. Mol Neurobiol. 2016;53(9):6144–54.CrossRefPubMed
18.
Zurück zum Zitat Martínez-Lapiscina EH, Clavero P, Toledo E, Estruch R, Salas-Salvadó J, San Julián B, et al. Mediterranean diet improves cognition: the PREDIMED-NAVARRA randomised trial. J Neurol Neurosurg Psychiatry. 2013;84(12):1318–25.CrossRefPubMed Martínez-Lapiscina EH, Clavero P, Toledo E, Estruch R, Salas-Salvadó J, San Julián B, et al. Mediterranean diet improves cognition: the PREDIMED-NAVARRA randomised trial. J Neurol Neurosurg Psychiatry. 2013;84(12):1318–25.CrossRefPubMed
19.
Zurück zum Zitat Valls-Pedret C, Sala-Vila A, Serra-Mir M, Corella D, de la Torre R, Martínez-González MÁ, et al. Mediterranean diet and age-related cognitive decline: a randomized clinical trial. JAMA Intern Med. 2015;175(7):1094–103.CrossRefPubMed Valls-Pedret C, Sala-Vila A, Serra-Mir M, Corella D, de la Torre R, Martínez-González MÁ, et al. Mediterranean diet and age-related cognitive decline: a randomized clinical trial. JAMA Intern Med. 2015;175(7):1094–103.CrossRefPubMed
20.
Zurück zum Zitat Matthews DC, Davies M, Murray J, Williams S, Tsui WH, Li Y, et al. Physical activity, Mediterranean diet and biomarkers-assessed risk of Alzheimer’s: a multi-modality brain imaging study. Adv J Mol Imaging. 2014;4(4):43–57.CrossRefPubMedPubMedCentral Matthews DC, Davies M, Murray J, Williams S, Tsui WH, Li Y, et al. Physical activity, Mediterranean diet and biomarkers-assessed risk of Alzheimer’s: a multi-modality brain imaging study. Adv J Mol Imaging. 2014;4(4):43–57.CrossRefPubMedPubMedCentral
21.
Zurück zum Zitat •• Mosconi L, Murray J, Tsui WH, Li Y, Davies M, Williams S, et al. Mediterranean diet and magnetic resonance imaging-assessed brain atrophy in cognitively normal individuals at risk for Alzheimer’s disease. J Prev Alzheimers Dis. 2014;1(1):23–32. This brain imaging paper was the first to show that people with lower adherence to the Mediterranean diet demonstrate accelerated brain aging as compared to those with higher adherence.PubMedPubMedCentral •• Mosconi L, Murray J, Tsui WH, Li Y, Davies M, Williams S, et al. Mediterranean diet and magnetic resonance imaging-assessed brain atrophy in cognitively normal individuals at risk for Alzheimer’s disease. J Prev Alzheimers Dis. 2014;1(1):23–32. This brain imaging paper was the first to show that people with lower adherence to the Mediterranean diet demonstrate accelerated brain aging as compared to those with higher adherence.PubMedPubMedCentral
22.
Zurück zum Zitat Gu Y, Brickman AM, Stern Y, Habeck CG, Razlighi QR, Luchsinger JA, et al. Mediterranean diet and brain structure in a multiethnic elderly cohort. Neurology. 2015;85(20):1744–51.CrossRefPubMedPubMedCentral Gu Y, Brickman AM, Stern Y, Habeck CG, Razlighi QR, Luchsinger JA, et al. Mediterranean diet and brain structure in a multiethnic elderly cohort. Neurology. 2015;85(20):1744–51.CrossRefPubMedPubMedCentral
23.
Zurück zum Zitat Appel LJ, Moore TJ, Obarzanek E, Vollmer WM, Svetkey LP, Sacks FM, et al. A clinical trial of the effects of dietary patterns on blood pressure. DASH collaborative research group. N Engl J Med. 1997;336(16):1117–24.CrossRefPubMed Appel LJ, Moore TJ, Obarzanek E, Vollmer WM, Svetkey LP, Sacks FM, et al. A clinical trial of the effects of dietary patterns on blood pressure. DASH collaborative research group. N Engl J Med. 1997;336(16):1117–24.CrossRefPubMed
24.
Zurück zum Zitat Launer LJ, Ross GW, Petrovitch H, Masaki K, Foley D, White LR, et al. Midlife blood pressure and dementia: the Honolulu-Asia aging study. Neurobiol Aging. 2000;21(1):49–55.CrossRefPubMed Launer LJ, Ross GW, Petrovitch H, Masaki K, Foley D, White LR, et al. Midlife blood pressure and dementia: the Honolulu-Asia aging study. Neurobiol Aging. 2000;21(1):49–55.CrossRefPubMed
25.
Zurück zum Zitat Berendsen AA, Kang JH, van de Rest O, Feskens EJ, de Groot LC, Grodstein F. (2017) The dietary approaches to stop hypertension diet, cognitive function, and cognitive decline in American older women. J Am Med Dir Assoc; In Press. Berendsen AA, Kang JH, van de Rest O, Feskens EJ, de Groot LC, Grodstein F. (2017) The dietary approaches to stop hypertension diet, cognitive function, and cognitive decline in American older women. J Am Med Dir Assoc; In Press.
26.
Zurück zum Zitat Smith PJ, Blumenthal JA, Babyak MA, Craighead L, Welsh-Bohmer KA, Browndyke JN, et al. Effects of the dietary approaches to stop hypertension diet, exercise, and caloric restriction on neurocognition in overweight adults with high blood pressure. Hypertension. 2010;55(6):1331–8.CrossRefPubMedPubMedCentral Smith PJ, Blumenthal JA, Babyak MA, Craighead L, Welsh-Bohmer KA, Browndyke JN, et al. Effects of the dietary approaches to stop hypertension diet, exercise, and caloric restriction on neurocognition in overweight adults with high blood pressure. Hypertension. 2010;55(6):1331–8.CrossRefPubMedPubMedCentral
27.
Zurück zum Zitat Morris MC, Tangney CC, Wang Y, Sacks FM, Barnes LL, Bennett DA, et al. MIND diet slows cognitive decline with aging. Alzheimers Dement. 2015;11(9):1015–22.CrossRefPubMedPubMedCentral Morris MC, Tangney CC, Wang Y, Sacks FM, Barnes LL, Bennett DA, et al. MIND diet slows cognitive decline with aging. Alzheimers Dement. 2015;11(9):1015–22.CrossRefPubMedPubMedCentral
28.
Zurück zum Zitat Barberger-Gateau P, Raffaitin C, Letenneur L, Berr C, Tzourio C, Dartigues JF, et al. Dietary patterns and risk of dementia: the Three-City cohort study. Neurology. 2007;69(20):1921–30.CrossRefPubMed Barberger-Gateau P, Raffaitin C, Letenneur L, Berr C, Tzourio C, Dartigues JF, et al. Dietary patterns and risk of dementia: the Three-City cohort study. Neurology. 2007;69(20):1921–30.CrossRefPubMed
29.
Zurück zum Zitat Li FJ, Shen L, Ji HF. Dietary intakes of vitamin E, vitamin C, and β-carotene and risk of Alzheimer’s disease: a meta-analysis. J Alzheimers Dis. 2012;31(2):253–8.PubMed Li FJ, Shen L, Ji HF. Dietary intakes of vitamin E, vitamin C, and β-carotene and risk of Alzheimer’s disease: a meta-analysis. J Alzheimers Dis. 2012;31(2):253–8.PubMed
30.
Zurück zum Zitat Gray SL, Anderson ML, Crane PK, Breitner JC, McCormick W, Bowen JD, et al. Antioxidant vitamin supplement use and risk of dementia or Alzheimer’s disease in older adults. J Am Geriatr Soc. 2008;56(2):291–5.CrossRefPubMed Gray SL, Anderson ML, Crane PK, Breitner JC, McCormick W, Bowen JD, et al. Antioxidant vitamin supplement use and risk of dementia or Alzheimer’s disease in older adults. J Am Geriatr Soc. 2008;56(2):291–5.CrossRefPubMed
31.
Zurück zum Zitat Engelhart MJ, Geerlings MI, Ruitenberg A, van Swieten JC, Hofman A, Witteman JC. Dietary intake of antioxidants and risk of Alzheimer disease. JAMA. 2002;287(24):3223–9.CrossRefPubMed Engelhart MJ, Geerlings MI, Ruitenberg A, van Swieten JC, Hofman A, Witteman JC. Dietary intake of antioxidants and risk of Alzheimer disease. JAMA. 2002;287(24):3223–9.CrossRefPubMed
32.
Zurück zum Zitat Van Dam F, Van Gool WA. Hyperhomocysteinemia and Alzheimer’s disease: a systematic review. Arch Gerontol Geriatr. 2009;48(3):425–30.CrossRefPubMed Van Dam F, Van Gool WA. Hyperhomocysteinemia and Alzheimer’s disease: a systematic review. Arch Gerontol Geriatr. 2009;48(3):425–30.CrossRefPubMed
33.
Zurück zum Zitat Corrada MM, Kawas CH, Hallfrisch J, Muller D, Brookmeyer R. Reduced risk of Alzheimer’s disease with high folate intake: the Baltimore Longitudinal Study of Aging. Alzheimers Dement. 2005;1(1):11–8.CrossRefPubMedPubMedCentral Corrada MM, Kawas CH, Hallfrisch J, Muller D, Brookmeyer R. Reduced risk of Alzheimer’s disease with high folate intake: the Baltimore Longitudinal Study of Aging. Alzheimers Dement. 2005;1(1):11–8.CrossRefPubMedPubMedCentral
34.
Zurück zum Zitat Luchsinger JA, Tang MX, Miller J, Green R, Mayeux R. Relation of higher folate intake to lower risk of Alzheimer disease in the elderly. Arch Neurol. 2007;64(1):86–92.CrossRefPubMed Luchsinger JA, Tang MX, Miller J, Green R, Mayeux R. Relation of higher folate intake to lower risk of Alzheimer disease in the elderly. Arch Neurol. 2007;64(1):86–92.CrossRefPubMed
35.
Zurück zum Zitat Lefèvre-Arbogast S, Féart C, Dartigues JF, Helmer C, Letenneur L, Samieri C. Dietary B vitamins and a 10-year risk of dementia in older persons. Nutrients. 2016;8(12):761–72.CrossRefPubMedCentral Lefèvre-Arbogast S, Féart C, Dartigues JF, Helmer C, Letenneur L, Samieri C. Dietary B vitamins and a 10-year risk of dementia in older persons. Nutrients. 2016;8(12):761–72.CrossRefPubMedCentral
36.
Zurück zum Zitat Morris MC, Evans DA, Bienias JL, Tangney CC, Hebert LE, Scherr PA, et al. Dietary folate and vitamin B12 intake and cognitive decline among community-dwelling older persons. Arch Neurol. 2005;62(4):641–5.CrossRefPubMed Morris MC, Evans DA, Bienias JL, Tangney CC, Hebert LE, Scherr PA, et al. Dietary folate and vitamin B12 intake and cognitive decline among community-dwelling older persons. Arch Neurol. 2005;62(4):641–5.CrossRefPubMed
37.
Zurück zum Zitat Nelson C, Wengreen HJ, Munger RG, Corcoran CD. Dietary folate, vitamin B-12, vitamin B-6 and incident Alzheimer’s disease: the cache county memory, health and aging study. J Nutr Health Aging. 2009;13(10):899–905.CrossRefPubMedPubMedCentral Nelson C, Wengreen HJ, Munger RG, Corcoran CD. Dietary folate, vitamin B-12, vitamin B-6 and incident Alzheimer’s disease: the cache county memory, health and aging study. J Nutr Health Aging. 2009;13(10):899–905.CrossRefPubMedPubMedCentral
38.
Zurück zum Zitat Wald DS, Kasturiratne A, Simmonds M. Effect of folic acid, with or without other B vitamins, on cognitive decline: meta-analysis of randomized trials. Am J Med. 2010;123(6):522–7.CrossRefPubMed Wald DS, Kasturiratne A, Simmonds M. Effect of folic acid, with or without other B vitamins, on cognitive decline: meta-analysis of randomized trials. Am J Med. 2010;123(6):522–7.CrossRefPubMed
39.
Zurück zum Zitat Ford AH, Almeida OP. Effect of homocysteine lowering treatment on cognitive function: a systematic review and meta-analysis of randomized controlled trials. J Alzheimers Dis. 2012;29(1):133–49.PubMed Ford AH, Almeida OP. Effect of homocysteine lowering treatment on cognitive function: a systematic review and meta-analysis of randomized controlled trials. J Alzheimers Dis. 2012;29(1):133–49.PubMed
40.
Zurück zum Zitat Smith AD, Smith SM, de Jager CA, Whitbread P, Johnston C, Agacinski G, et al. Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial. PLoS One. 2010;5:e12244.CrossRefPubMedPubMedCentral Smith AD, Smith SM, de Jager CA, Whitbread P, Johnston C, Agacinski G, et al. Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial. PLoS One. 2010;5:e12244.CrossRefPubMedPubMedCentral
41.
Zurück zum Zitat de Jager CA, Oulhaj A, Jacoby R, Refsum H, Smith AD. Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in mild cognitive impairment: a randomized controlled trial. Int J Geriatr Psychiatry. 2012;27(6):592–600.CrossRefPubMed de Jager CA, Oulhaj A, Jacoby R, Refsum H, Smith AD. Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in mild cognitive impairment: a randomized controlled trial. Int J Geriatr Psychiatry. 2012;27(6):592–600.CrossRefPubMed
42.
Zurück zum Zitat Oulhaj A, Jernerén F, Refsum H, Smith AD, de Jager CA. Omega-3 fatty acid status enhances the prevention of cognitive decline by b vitamins in mild cognitive impairment. J Alzheimers Dis. 2016;50(2):547–57.CrossRefPubMedPubMedCentral Oulhaj A, Jernerén F, Refsum H, Smith AD, de Jager CA. Omega-3 fatty acid status enhances the prevention of cognitive decline by b vitamins in mild cognitive impairment. J Alzheimers Dis. 2016;50(2):547–57.CrossRefPubMedPubMedCentral
43.
Zurück zum Zitat • Jernerén F, Elshorbagy AK, Oulhaj A, Smith SM, Refsum H, Smith AD. Brain atrophy in cognitively impaired elderly: the importance of long-chain ω-3 fatty acids and B vitamin status in a randomized controlled trial. Am J Clin Nutr. 2015;102(1):215–21. This retrospective analysis of a randomized controlled trial demonstrates that high-dose B vitamin treatment is effective at slowing down brain atrophy in MCI patients with high baseline ω-3 PUFA concentrations.CrossRefPubMed • Jernerén F, Elshorbagy AK, Oulhaj A, Smith SM, Refsum H, Smith AD. Brain atrophy in cognitively impaired elderly: the importance of long-chain ω-3 fatty acids and B vitamin status in a randomized controlled trial. Am J Clin Nutr. 2015;102(1):215–21. This retrospective analysis of a randomized controlled trial demonstrates that high-dose B vitamin treatment is effective at slowing down brain atrophy in MCI patients with high baseline ω-3 PUFA concentrations.CrossRefPubMed
44.
Zurück zum Zitat Fotuhi M, Mohassel P, Yaffe K. Fish consumption, long-chain omega-3 fatty acids and risk of cognitive decline or Alzheimer disease: a complex association. Nat Clin Pract Neurol. 2009;5(3):140–52.CrossRefPubMed Fotuhi M, Mohassel P, Yaffe K. Fish consumption, long-chain omega-3 fatty acids and risk of cognitive decline or Alzheimer disease: a complex association. Nat Clin Pract Neurol. 2009;5(3):140–52.CrossRefPubMed
45.
Zurück zum Zitat Morris MC, Evans DA, Bienias JL, Tangney CC, Bennett DA, Wilson RS, et al. Consumption of fish and n-3 fatty acids and risk of incident Alzheimer disease. Arch Neurol. 2003;60(7):940–6.CrossRefPubMed Morris MC, Evans DA, Bienias JL, Tangney CC, Bennett DA, Wilson RS, et al. Consumption of fish and n-3 fatty acids and risk of incident Alzheimer disease. Arch Neurol. 2003;60(7):940–6.CrossRefPubMed
47.
Zurück zum Zitat •• Mosconi L, Murray J, Davies M, Williams S, Pirraglia E, Spector N, et al. Nutrient intake and brain biomarkers of Alzheimer’s in at-risk cognitively normal individuals: a cross-sectional neuroimaging pilot study. BMJ Open. 2014;4(6):e004850. This is the first multi-modality brain imaging paper showing associations between nutrient patterns and major brain biomarkers of AD in cognitively normal people.CrossRefPubMedPubMedCentral •• Mosconi L, Murray J, Davies M, Williams S, Pirraglia E, Spector N, et al. Nutrient intake and brain biomarkers of Alzheimer’s in at-risk cognitively normal individuals: a cross-sectional neuroimaging pilot study. BMJ Open. 2014;4(6):e004850. This is the first multi-modality brain imaging paper showing associations between nutrient patterns and major brain biomarkers of AD in cognitively normal people.CrossRefPubMedPubMedCentral
48.
Zurück zum Zitat Institute of Medicine. (2006) Dietary reference intakes: the essential guide to nutrient requirements. Washington, DC: The National Academies Press. doi: 10.17226/11537. Institute of Medicine. (2006) Dietary reference intakes: the essential guide to nutrient requirements. Washington, DC: The National Academies Press. doi: 10.​17226/​11537.
49.
Zurück zum Zitat Morris MC, Evans DA, Tangney CC, Bienias JL, Wilson RS. Fish consumption and cognitive decline with age in a large community study. Arch Neurol. 2005;62(12):1849–53.CrossRefPubMed Morris MC, Evans DA, Tangney CC, Bienias JL, Wilson RS. Fish consumption and cognitive decline with age in a large community study. Arch Neurol. 2005;62(12):1849–53.CrossRefPubMed
50.
Zurück zum Zitat van de Rest O, Wang Y, Barnes LL, Tangney C, Bennett DA, Morris MC. APOE ε4 and the associations of seafood and long-chain omega-3 fatty acids with cognitive decline. Neurology. 2016;86(22):2063–70.CrossRefPubMed van de Rest O, Wang Y, Barnes LL, Tangney C, Bennett DA, Morris MC. APOE ε4 and the associations of seafood and long-chain omega-3 fatty acids with cognitive decline. Neurology. 2016;86(22):2063–70.CrossRefPubMed
51.
Zurück zum Zitat Kalmijn S, Launer LJ, Ott A, Witteman JC, Hofman A, Breteler MM. Dietary fat intake and the risk of incident dementia in the Rotterdam Study. Ann Neurol. 1997;42(5):776–82.CrossRefPubMed Kalmijn S, Launer LJ, Ott A, Witteman JC, Hofman A, Breteler MM. Dietary fat intake and the risk of incident dementia in the Rotterdam Study. Ann Neurol. 1997;42(5):776–82.CrossRefPubMed
52.
Zurück zum Zitat Morris MC, Brockman J, Schneider JA, Wang Y, Bennett DA, Tangney CC, et al. Association of seafood consumption, brain mercury level, and APOE ε4 status with brain neuropathology in older adults. JAMA. 2016;315(5):489–97.CrossRefPubMed Morris MC, Brockman J, Schneider JA, Wang Y, Bennett DA, Tangney CC, et al. Association of seafood consumption, brain mercury level, and APOE ε4 status with brain neuropathology in older adults. JAMA. 2016;315(5):489–97.CrossRefPubMed
53.
Zurück zum Zitat Burckhardt M, Herke M, Wustmann T, Watzke S, Langer G, Fink A. Omega-3 fatty acids for the treatment of dementia. Cochrane Database Syst Rev. 2016;4:CD009002.PubMed Burckhardt M, Herke M, Wustmann T, Watzke S, Langer G, Fink A. Omega-3 fatty acids for the treatment of dementia. Cochrane Database Syst Rev. 2016;4:CD009002.PubMed
54.
Zurück zum Zitat Solfrizzi V, Colacicco AM, D’Introno A, Capurso C, Del Parigi A, Capurso SA, et al. Dietary fatty acids intakes and rate of mild cognitive impairment. The Italian Longitudinal Study on Aging. Exp Gerontol. 2006;41(6):619–27.CrossRefPubMed Solfrizzi V, Colacicco AM, D’Introno A, Capurso C, Del Parigi A, Capurso SA, et al. Dietary fatty acids intakes and rate of mild cognitive impairment. The Italian Longitudinal Study on Aging. Exp Gerontol. 2006;41(6):619–27.CrossRefPubMed
55.
Zurück zum Zitat Solfrizzi V, Colacicco AM, D’Introno A, Capurso C, Torres F, Rizzo C, et al. Dietary intake of unsaturated fatty acids and age-related cognitive decline: a 8.5-year follow-up of the Italian Longitudinal Study on Aging. Neurobiol Aging. 2006;27(11):1694–704.CrossRefPubMed Solfrizzi V, Colacicco AM, D’Introno A, Capurso C, Torres F, Rizzo C, et al. Dietary intake of unsaturated fatty acids and age-related cognitive decline: a 8.5-year follow-up of the Italian Longitudinal Study on Aging. Neurobiol Aging. 2006;27(11):1694–704.CrossRefPubMed
56.
Zurück zum Zitat Mahan KL, Raymond JL. Krause’s food and the nutrition care process. 14th ed. St. Louis, MI: Elsevier; 2017. Mahan KL, Raymond JL. Krause’s food and the nutrition care process. 14th ed. St. Louis, MI: Elsevier; 2017.
57.
Zurück zum Zitat Berr C, Portet F, Carriere I, Akbaraly TN, Feart C, Gourlet V. Olive oil and cognition: results from the three-city study. Dement Geriatr Cogn Disord. 2009;28(4):357–64.CrossRefPubMedPubMedCentral Berr C, Portet F, Carriere I, Akbaraly TN, Feart C, Gourlet V. Olive oil and cognition: results from the three-city study. Dement Geriatr Cogn Disord. 2009;28(4):357–64.CrossRefPubMedPubMedCentral
58.
Zurück zum Zitat • Morris MC, Tangney CC. Dietary fat composition and dementia risk. Neurobiol Aging. 2014;35(Suppl 2):S59–64. This review paper summarizes the literature available on dietary fatty acid composition and its effect on AD or dementia risk and cognitive decline. This paper also provides an explanation as to the mixed findings of epidemiological studies investigating dietary fatty acid composition.CrossRefPubMed • Morris MC, Tangney CC. Dietary fat composition and dementia risk. Neurobiol Aging. 2014;35(Suppl 2):S59–64. This review paper summarizes the literature available on dietary fatty acid composition and its effect on AD or dementia risk and cognitive decline. This paper also provides an explanation as to the mixed findings of epidemiological studies investigating dietary fatty acid composition.CrossRefPubMed
59.
Zurück zum Zitat Barnard ND, Bunner AE, Agarwal U. Saturated and trans fats and dementia: a systematic review. Neurobiol Aging. 2014;35(Suppl 2):S65–73.CrossRefPubMed Barnard ND, Bunner AE, Agarwal U. Saturated and trans fats and dementia: a systematic review. Neurobiol Aging. 2014;35(Suppl 2):S65–73.CrossRefPubMed
60.
Zurück zum Zitat Morris MC, Evans DA, Bienias JL, Tangney CC, Bennett DA, Aggarwal N, et al. Dietary fats and the risk of incident Alzheimer disease. Arch Neurol. 2003;60(2):194–200.CrossRefPubMed Morris MC, Evans DA, Bienias JL, Tangney CC, Bennett DA, Aggarwal N, et al. Dietary fats and the risk of incident Alzheimer disease. Arch Neurol. 2003;60(2):194–200.CrossRefPubMed
61.
Zurück zum Zitat Morrison JH, Hof PR. Life and death of neurons in the aging brain. Science. 1997;278:412–9.CrossRefPubMed Morrison JH, Hof PR. Life and death of neurons in the aging brain. Science. 1997;278:412–9.CrossRefPubMed
62.
Zurück zum Zitat Haass C, Selkoe DJ. Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer’s amyloid beta-peptide. Nat Rev Mol Cell Biol. 2007;8(2):101–12.CrossRefPubMed Haass C, Selkoe DJ. Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer’s amyloid beta-peptide. Nat Rev Mol Cell Biol. 2007;8(2):101–12.CrossRefPubMed
63.
Zurück zum Zitat Mosconi L. Glucose metabolism in normal aging and Alzheimer’s disease: methodological and physiological considerations for PET studies. Clin Transl Imaging. 2013;1(4):217–33.CrossRef Mosconi L. Glucose metabolism in normal aging and Alzheimer’s disease: methodological and physiological considerations for PET studies. Clin Transl Imaging. 2013;1(4):217–33.CrossRef
64.
Zurück zum Zitat Mosconi L, McHugh PF. Let food be thy medicine: diet, nutrition, and biomarkers’ risk of Alzheimer’s disease. Curr Nutr Rep. 2015;4(2):126–35.CrossRefPubMedPubMedCentral Mosconi L, McHugh PF. Let food be thy medicine: diet, nutrition, and biomarkers’ risk of Alzheimer’s disease. Curr Nutr Rep. 2015;4(2):126–35.CrossRefPubMedPubMedCentral
65.
Zurück zum Zitat Bowman GL, Silbert LC, Howieson D, Dodge HH, Traber MG, Frei B, et al. Nutrient biomarker patterns, cognitive function, and MRI measures of brain aging. Neurology. 2012;78(4):241–9.CrossRefPubMedPubMedCentral Bowman GL, Silbert LC, Howieson D, Dodge HH, Traber MG, Frei B, et al. Nutrient biomarker patterns, cognitive function, and MRI measures of brain aging. Neurology. 2012;78(4):241–9.CrossRefPubMedPubMedCentral
66.
Zurück zum Zitat Berti V, Murray J, Davies M, Spector N, Tsui WH, Li Y, et al. Nutrient patterns and brain biomarkers of Alzheimer’s disease in cognitively normal individuals. J Nutr Health Aging. 2015;19(4):413–23.CrossRefPubMedPubMedCentral Berti V, Murray J, Davies M, Spector N, Tsui WH, Li Y, et al. Nutrient patterns and brain biomarkers of Alzheimer’s disease in cognitively normal individuals. J Nutr Health Aging. 2015;19(4):413–23.CrossRefPubMedPubMedCentral
67.
Zurück zum Zitat Schelke MW, Hackett K, Chen JL, Shih C, Shum J, Montgomery ME, et al. Nutritional interventions for Alzheimer’s prevention: a clinical precision medicine approach. Ann N Y Acad Sci. 2016;1367(1):50–6.CrossRefPubMed Schelke MW, Hackett K, Chen JL, Shih C, Shum J, Montgomery ME, et al. Nutritional interventions for Alzheimer’s prevention: a clinical precision medicine approach. Ann N Y Acad Sci. 2016;1367(1):50–6.CrossRefPubMed
68.
Zurück zum Zitat Dangour AD, Whitehouse PJ, Rafferty K, Mitchell SA, Smith L, Hawkesworth S, et al. B-vitamins and fatty acids in the prevention and treatment of Alzheimer’s disease and dementia: a systematic review. J Alzheimers Dis. 2010;22(1):205–24.CrossRefPubMed Dangour AD, Whitehouse PJ, Rafferty K, Mitchell SA, Smith L, Hawkesworth S, et al. B-vitamins and fatty acids in the prevention and treatment of Alzheimer’s disease and dementia: a systematic review. J Alzheimers Dis. 2010;22(1):205–24.CrossRefPubMed
69.
Zurück zum Zitat • Shah R. The role of nutrition and diet in Alzheimer disease: a systematic review. J Am Med Dir Assoc. 2013;14(6):398–402. Noteworthy systematic review paper about the effects of MeDi and food combinations on AD risk.CrossRefPubMed • Shah R. The role of nutrition and diet in Alzheimer disease: a systematic review. J Am Med Dir Assoc. 2013;14(6):398–402. Noteworthy systematic review paper about the effects of MeDi and food combinations on AD risk.CrossRefPubMed
70.
Zurück zum Zitat Craft S. Insulin resistance and Alzheimer’s disease pathogenesis: potential mechanisms and implications for treatment. Curr Alzheimer Res. 2007;4(2):14752.CrossRef Craft S. Insulin resistance and Alzheimer’s disease pathogenesis: potential mechanisms and implications for treatment. Curr Alzheimer Res. 2007;4(2):14752.CrossRef
71.
Zurück zum Zitat Ryan M, McInerney D, Owens D, Collins P, Johnson A, Tomkin GH. Diabetes and the Mediterranean diet: a beneficial effect of oleic acid on insulin sensitivity, adipocyte glucose transport and endothelium-dependent vasoreactivity. QJM. 2000;93(2):85–91.CrossRefPubMed Ryan M, McInerney D, Owens D, Collins P, Johnson A, Tomkin GH. Diabetes and the Mediterranean diet: a beneficial effect of oleic acid on insulin sensitivity, adipocyte glucose transport and endothelium-dependent vasoreactivity. QJM. 2000;93(2):85–91.CrossRefPubMed
72.
Zurück zum Zitat Mastroiacovo D, Kwik-Uribe C, Grassi D, Necozione S, Raffaele A, Pistacchio L, et al. Cocoa flavanol consumption improves cognitive function, blood pressure control, and metabolic profile in elderly subjects: the Cocoa, Cognition, and Aging (CoCoA) Study—a randomized controlled trial. Am J Clin Nutr. 2015;101(3):538–48.CrossRefPubMed Mastroiacovo D, Kwik-Uribe C, Grassi D, Necozione S, Raffaele A, Pistacchio L, et al. Cocoa flavanol consumption improves cognitive function, blood pressure control, and metabolic profile in elderly subjects: the Cocoa, Cognition, and Aging (CoCoA) Study—a randomized controlled trial. Am J Clin Nutr. 2015;101(3):538–48.CrossRefPubMed
73.
Zurück zum Zitat Roberts LD, Koulman A, Griffin JL. Towards metabolic biomarkers of insulin resistance and type 2 diabetes: progress from the metabolome. Lancet Diabetes Endocrinol. 2014;2(1):65–7.CrossRefPubMed Roberts LD, Koulman A, Griffin JL. Towards metabolic biomarkers of insulin resistance and type 2 diabetes: progress from the metabolome. Lancet Diabetes Endocrinol. 2014;2(1):65–7.CrossRefPubMed
75.
76.
Zurück zum Zitat Morris MC, Evans DA, Bienias JL, Scherr PA, Tangney CC, Hebert LE, et al. Dietary niacin and the risk of incident Alzheimer’s disease and of cognitive decline. J Neurol Neurosurg Psychiatry. 2004;75(8):1093–9.CrossRefPubMedPubMedCentral Morris MC, Evans DA, Bienias JL, Scherr PA, Tangney CC, Hebert LE, et al. Dietary niacin and the risk of incident Alzheimer’s disease and of cognitive decline. J Neurol Neurosurg Psychiatry. 2004;75(8):1093–9.CrossRefPubMedPubMedCentral
77.
Zurück zum Zitat Harris WS, Miller M, Tighe AP, Davidson MH, Schaefer EJ. Omega-3 fatty acids and coronary heart disease risk: clinical and mechanistic perspectives. Atherosclerosis. 2008;197(1):12–24.CrossRefPubMed Harris WS, Miller M, Tighe AP, Davidson MH, Schaefer EJ. Omega-3 fatty acids and coronary heart disease risk: clinical and mechanistic perspectives. Atherosclerosis. 2008;197(1):12–24.CrossRefPubMed
78.
Zurück zum Zitat Uttara B, Singh AV, Zamboni P, Mahajan RT. Oxidative stress and neurodegenerative diseases: a review of upstream and downstream antioxidant therapeutic options. Curr Neuropharmacol. 2009;7(1):65–74.CrossRefPubMedPubMedCentral Uttara B, Singh AV, Zamboni P, Mahajan RT. Oxidative stress and neurodegenerative diseases: a review of upstream and downstream antioxidant therapeutic options. Curr Neuropharmacol. 2009;7(1):65–74.CrossRefPubMedPubMedCentral
80.
Metadaten
Titel
Role of Nutrition to Promote Healthy Brain Aging and Reduce Risk of Alzheimer’s Disease
verfasst von
Michelle Walters
Katherine Hackett
Emily Caesar
Richard Isaacson
Lisa Mosconi
Publikationsdatum
29.04.2017
Verlag
Springer US
Erschienen in
Current Nutrition Reports / Ausgabe 2/2017
Elektronische ISSN: 2161-3311
DOI
https://doi.org/10.1007/s13668-017-0199-5

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