Introduction
PF-4 physiology and function
CTAP-III physiology and function
Regulation of hematopoiesis
| Inhibition of megakaryocytopoiesis [19] |
Immunoregulatory activity
| Histamine release by basophils [37] |
Precursor of NAP-2 [31] | |
Angiogenesis
| Chemotaxis of EC in vitro[5] |
Connective tissue cells metabolism
| Mitogenesis [34] |
Glycolysis [34] | |
Prostaglandin E2 secretion [22] | |
Plasminogen activator synthesis [35] | |
Others
| Stimulation of glucose transport [38] |
Transcellular mediator of the cellular sphingomyelin import [39] | |
Heparanase activity [40] |
Platelet regulation of tumor angiogenesis and tumor growth
PF-4, as an angiogenesis inhibitor
Regulation of tumor angiogenesis and tumor growth: connection with tumor microenvironment and the immune system
Procoagulant activity
| Inhibition of heparin-dependent thrombin inactivation [15] |
Anticoagulant activity
| |
Generation of activated protein C [18] | |
Regulation of hematopoiesis
| |
Survival of hematopoietic and progenitor cells [73] | |
Immunoregulatory activity
| |
Stimulation of eosinophil adhesion [79] | |
Stimulation of histamine release by basophils [80] | |
Activation of NK cells and IL-8 release [81] | |
Inhibition of T-cell activation and proliferation [82] | |
Anti-angiogenic activity
| |
Prevention of EC entry into S phase and inhibition of DNA synthesis [56] | |
Monocyte ROS mediated cytotoxicity for EC [64] |