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Metabolic Brain Disease

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26.09.2018 | Original Article

Role of PUMA in the methamphetamine-induced migration of microglia

verfasst von: Lei Zhao, Longfei Du, Yanhong Zhang, Jie Chao, Ming Duan, Honghong Yao, Chuanlu Shen, Yuan Zhang

Erschienen in: Metabolic Brain Disease | Ausgabe 1/2019

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Abstract

In this study, we demonstrated that PUMA was involved in the microglial migration induced by methamphetamine. PUMA expression was examined by western blotting and immunofluorescence staining. BV2 and HAPI cells were pretreated with a sigma-1R antagonist and extracellular signal-regulated kinase (ERK), mitogen-activated protein kinase (MAPK), c-Jun N-terminal protein kinase (JNK), and phosphatidylinositol-3 kinase (PI3K)/Akt inhibitors, and PUMA expression was detected by western blotting. The cell migration in BV2 and HAPI cells transfected with a lentivirus encoding red fluorescent protein (LV-RFP) was also examined using a wound-healing assay and nested matrix model and cell migration assay respectively. The molecular mechanisms of PUMA in microglial migration were validated using a siRNA approach. The exposure of BV2 and HAPI cells to methamphetamine increased the expression of PUMA, reactive oxygen species (ROS), the MAPK and PI3K/Akt pathways and the downstream transcription factor signal transducer and activator of transcription 3 (STAT3) pathways. PUMA knockdown in microglia transfected with PUMA siRNA attenuated the increased cell migration induced by methamphetamine, thereby implicating PUMA in the migration of BV2 and HAPI cells. This study demonstrated that methamphetamine-induced microglial migration involved PUMA up-regulation. Targeting PUMA could provide insights into the development of a potential therapeutic approach for the alleviation of microglia migration induced by methamphetamine.

Chipuk JE, Bouchier-Hayes L, Kuwana T, Newmeyer DD, Green DR (2005) PUMA couples the nuclear and cytoplasmic proapoptotic function of p53. Science (New York, NY) 309:1732–1735. https://doi.org/10.1126/science.1114297 CrossRefPubMed

Cregan SP, Arbour NA, Maclaurin JG, Callaghan SM, Fortin A, Cheung EC, Guberman DS, Park DS, Slack RS (2004) p53 activation domain 1 is essential for PUMA upregulation and p53-mediated neuronal cell death. J Neurosci Off J Soc Neurosci 24:10003–10012. https://doi.org/10.1523/jneurosci.2114-04.2004 CrossRef

Deguchi A (2015) Curcumin targets in inflammation and cancer. Endocr Metab Immune Disord Drug Targets 15:88–96CrossRef

Gekker G, Hu S, Sheng WS, Rock RB, Lokensgard JR, Peterson PK (2006) Cocaine-induced HIV-1 expression in microglia involves sigma-1 receptors and transforming growth factor-beta1. Int Immunopharmacol 6:1029–1033. https://doi.org/10.1016/j.intimp.2005.12.005 CrossRefPubMed

Gonzalez B, Raineri M, Cadet JL, Garcia-Rill E, Urbano FJ, Bisagno V (2014) Modafinil improves methamphetamine-induced object recognition deficits and restores prefrontal cortex ERK signaling in mice. Neuropharmacology 87:188–197. https://doi.org/10.1016/j.neuropharm.2014.02.002 CrossRefPubMedPubMedCentral

Harro J (2015) Neuropsychiatric adverse effects of amphetamine and methamphetamine. Int Rev Neurobiol 120:179–204. https://doi.org/10.1016/bs.irn.2015.02.004 CrossRefPubMed

Hickman SE, El Khoury J (2010) Mechanisms of mononuclear phagocyte recruitment in Alzheimer's disease. CNS Neurol Disord Drug Targets 9:168–173CrossRef

Hikisz P, Kilianska ZM (2012) PUMA, a critical mediator of cell death--one decade on from its discovery. Cell Mol Biol Lett 17:646–669. https://doi.org/10.2478/s11658-012-0032-5 CrossRefPubMedPubMedCentral

Krasnova IN, Justinova Z, Cadet JL (2016) Methamphetamine addiction: involvement of CREB and neuroinflammatory signaling pathways. Psychopharmacology 233:1945–1962. https://doi.org/10.1007/s00213-016-4235-8 CrossRefPubMedPubMedCentral

LeComte MD, Shimada IS, Sherwin C, Spees JL (2015) Notch1-STAT3-ETBR signaling axis controls reactive astrocyte proliferation after brain injury. Proc Natl Acad Sci U S A 112:8726–8731. https://doi.org/10.1073/pnas.1501029112 CrossRefPubMedPubMedCentral

Li X, Liu S, Luo J, Liu A, Tang S, Liu S, Yu M, Zhang Y (2015) Helicobacter pylori induces IL-1beta and IL-18 production in human monocytic cell line through activation of NLRP3 inflammasome via ROS signaling pathway. Pathog Dis 73. https://doi.org/10.1093/femspd/ftu024

Liao K, Guo M, Niu F, Yang L, Callen SE, Buch S (2016) Cocaine-mediated induction of microglial activation involves the ER stress-TLR2 axis. J Neuroinflammation 13:33. https://doi.org/10.1186/s12974-016-0501-2 CrossRefPubMedPubMedCentral

Liu S, Mi WL, Li Q, Zhang MT, Han P, Hu S, Mao-Ying QL, Wang YQ (2015) Spinal IL-33/ST2 signaling contributes to neuropathic pain via neuronal CaMKII-CREB and Astroglial JAK2-STAT3 cascades in mice. Anesthesiology 123:1154–1169. https://doi.org/10.1097/aln.0000000000000850 CrossRefPubMed

Lull ME, Block ML (2010) Microglial activation and chronic neurodegeneration. Neurotherapeutics 7:354–365. https://doi.org/10.1016/j.nurt.2010.05.014 CrossRefPubMedPubMedCentral

Ma J, Wan J, Meng J, Banerjee S, Ramakrishnan S, Roy S (2014) Methamphetamine induces autophagy as a pro-survival response against apoptotic endothelial cell death through the kappa opioid receptor. Cell Death Dis 5:e1099. https://doi.org/10.1038/cddis.2014.64 CrossRefPubMedPubMedCentral

McConnell SE, O'Banion MK, Cory-Slechta DA, Olschowka JA, Opanashuk LA (2015) Characterization of binge-dosed methamphetamine-induced neurotoxicity and neuroinflammation. Neurotoxicology 50:131–141. https://doi.org/10.1016/j.neuro.2015.08.006 CrossRefPubMedPubMedCentral

Muhl H (2016) STAT3, a key parameter of cytokine-driven tissue protection during sterile inflammation - the case of experimental acetaminophen (paracetamol)-induced liver damage. Front Immunol 7:163. https://doi.org/10.3389/fimmu.2016.00163 CrossRefPubMedPubMedCentral

Peri F, Nusslein-Volhard C (2008) Live imaging of neuronal degradation by microglia reveals a role for v0-ATPase a1 in phagosomal fusion in vivo. Cell 133:916–927. https://doi.org/10.1016/j.cell.2008.04.037 CrossRefPubMed

Riddle EL, Fleckenstein AE, Hanson GR (2006) Mechanisms of methamphetamine-induced dopaminergic neurotoxicity. AAPS J 8:E413–E418CrossRef

Robson MJ, Turner RC, Naser ZJ, McCurdy CR, Huber JD, Matsumoto RR (2013) SN79, a sigma receptor ligand, blocks methamphetamine-induced microglial activation and cytokine upregulation. Exp Neurol 247:134–142. https://doi.org/10.1016/j.expneurol.2013.04.009 CrossRefPubMedPubMedCentral

Rostasy KM (2005) Inflammation and neuroaxonal injury in multiple sclerosis and AIDS dementia complex: implications for neuroprotective treatment. Neuropediatrics 36:230–239. https://doi.org/10.1055/s-2005-865864 CrossRefPubMed

Saika F, Kiguchi N, Kishioka S (2015) The role of CC-chemokine ligand 2 in the development of psychic dependence on methamphetamine. Nihon Arukoru Yakubutsu Igakkai Zasshi 50:189–195PubMed

Seminerio MJ, Robson MJ, McCurdy CR, Matsumoto RR (2012) Sigma receptor antagonists attenuate acute methamphetamine-induced hyperthermia by a mechanism independent of IL-1beta mRNA expression in the hypothalamus. Eur J Pharmacol 691:103–109. https://doi.org/10.1016/j.ejphar.2012.07.029 CrossRefPubMedPubMedCentral

Sharma HS, Kiyatkin EA (2009) Rapid morphological brain abnormalities during acute methamphetamine intoxication in the rat: an experimental study using light and electron microscopy. J Chem Neuroanat 37:18–32. https://doi.org/10.1016/j.jchemneu.2008.08.002 CrossRefPubMed

Shi JX, Wang QJ, Li H, Huang Q (2016) Silencing of USP22 suppresses high glucose-induced apoptosis, ROS production and inflammation in podocytes. Mol BioSyst 12:1445–1456. https://doi.org/10.1039/c5mb00722d CrossRefPubMed

Shin EJ, Shin SW, Nguyen TTL, Park DH, Wie MB, Jang CG, Nah SY, Yang BW, Ko SK, Nabeshima T, Kim HC (2014) Ginsenoside re rescues methamphetamine-induced oxidative damage, mitochondrial dysfunction, microglial activation, and dopaminergic degeneration by inhibiting the protein kinase Cdelta gene. Mol Neurobiol 49:1400–1421. https://doi.org/10.1007/s12035-013-8617-1 CrossRefPubMed

Thomas DM, Dowgiert J, Geddes TJ, Francescutti-Verbeem D, Liu X, Kuhn DM (2004) Microglial activation is a pharmacologically specific marker for the neurotoxic amphetamines. Neurosci Lett 367:349–354. https://doi.org/10.1016/j.neulet.2004.06.065 CrossRefPubMed

Vavrova J, Rezacova M (2014) Importance of proapoptotic protein PUMA in cell radioresistance. Folia Biol 60:53–56

Venneti S, Wiley CA, Kofler J (2009) Imaging microglial activation during neuroinflammation and Alzheimer's disease. J Neuroimmune Pharmacol 4:227–243. https://doi.org/10.1007/s11481-008-9142-2 CrossRefPubMed

Vousden KH (2005) Apoptosis. p53 and PUMA: a deadly duo. Science (New York, NY) 309:1685–1686. https://doi.org/10.1126/science.1118232 CrossRefPubMed

Wake H, Moorhouse AJ, Miyamoto A, Nabekura J (2013) Microglia: actively surveying and shaping neuronal circuit structure and function. Trends Neurosci 36:209–217. https://doi.org/10.1016/j.tins.2012.11.007 CrossRefPubMed

Wang SF, Yen JC, Yin PH, Chi CW, Lee HC (2008) Involvement of oxidative stress-activated JNK signaling in the methamphetamine-induced cell death of human SH-SY5Y cells. Toxicology 246:234–241. https://doi.org/10.1016/j.tox.2008.01.020 CrossRefPubMed

Wang W, Liu H, Dai X, Fang S, Wang X, Zhang Y, Yao H, Zhang X, Chao J (2015) p53/PUMA expression in human pulmonary fibroblasts mediates cell activation and migration in silicosis. Sci Rep 5:16900. https://doi.org/10.1038/srep16900 CrossRefPubMedPubMedCentral

Xiong XY, Liu L, Yang QW (2016) Functions and mechanisms of microglia/macrophages in neuroinflammation and neurogenesis after stroke. Prog Neurobiol 142:23–44. https://doi.org/10.1016/j.pneurobio.2016.05.001 CrossRefPubMed

Yao H, Ma R, Yang L, Hu G, Chen X, Duan M, Kook Y, Niu F, Liao K, Fu M, Hu G, Kolattukudy P, Buch S (2014) MiR-9 promotes microglial activation by targeting MCPIP1. Nat Commun 5:4386. https://doi.org/10.1038/ncomms5386 CrossRefPubMedPubMedCentral

Yao H, Yang Y, Kim KJ, Bethel-Brown C, Gong N, Funa K, Gendelman HE, Su TP, Wang JQ, Buch S (2010) Molecular mechanisms involving sigma receptor-mediated induction of MCP-1: implication for increased monocyte transmigration. Blood 115:4951–4962. https://doi.org/10.1182/blood-2010-01-266221 CrossRefPubMedPubMedCentral

Yuan Y, Fang M, Wu CY, Ling EA (2016) Scutellarin as a potential therapeutic agent for microglia-mediated Neuroinflammation in cerebral ischemia. NeuroMolecular Med 18:264–273. https://doi.org/10.1007/s12017-016-8394-x CrossRefPubMed

Zhang Y, Lv X, Bai Y, Zhu X, Wu X, Chao J, Duan M, Buch S, Chen L, Yao H (2015) Involvement of sigma-1 receptor in astrocyte activation induced by methamphetamine via up-regulation of its own expression. J Neuroinflammation 12:29. https://doi.org/10.1186/s12974-015-0250-7 CrossRefPubMedPubMedCentral

Titel: Role of PUMA in the methamphetamine-induced migration of microglia
verfasst von: Lei Zhao
Longfei Du
Yanhong Zhang
Jie Chao
Ming Duan
Honghong Yao
Chuanlu Shen
Yuan Zhang
Publikationsdatum: 26.09.2018
Verlag: Springer US
Erschienen in: Metabolic Brain Disease / Ausgabe 1/2019
Print ISSN: 0885-7490
Elektronische ISSN: 1573-7365
DOI: https://doi.org/10.1007/s11011-018-0319-y

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Role of PUMA in the methamphetamine-induced migration of microglia

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