The online version of this article (doi:10.1186/1477-7827-10-109) contains supplementary material, which is available to authorized users.
The authors declare that they have no competing interests.
SD participated in the original idea, carried out the literature (medline) search, compilation of the information, drafting and finalizing the paper. KK participated in compilation of the information and critical review of the paper. RKS conceived the study, participated in the study design compilation of the contents and critical review of the paper. AA provided substantial contribution ranging from study idea, design, critical review of the final paper. All authors read and approved the final manuscript.
Reactive nitrogen species (RNS) is a subset of free oxygen radicals called reactive oxygen species (ROS). Physiological levels of ROS are necessary to maintain the reproductive functions such as cell signaling, tight junction regulation, production of hormones, capacitation, acrosomal reaction, sperm motility, and zona pellucida binding. However, an excess of RNS can adversely affect reproductive potential by causing testicular dysfunction, decreased gonadotropin secretion, and abnormal semen parameters. Because such levels of RNS have been demonstrated in males with fertility problems and routine semen analysis has not been able to accurately predict IVF outcomes, it is imperative that novel strategies be developed in order to both assess and treat oxidative stress. This article describes both physiological and pathological roles of this unique subset of ROS.
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- Role of reactive nitrogen species in male infertility
Sejal B Doshi
Rakesh K Sharma
- BioMed Central
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