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02.05.2019

Role of Speckle Tracking Echocardiography in the Evaluation of Breast Cancer Patients Undergoing Chemotherapy: Review and Meta-analysis of the Literature

verfasst von: Corinna Bergamini, Giulia Dolci, Stella Truong, Luisa Zanolla, Giovanni Benfari, Elena Fiorio, Andrea Rossi, Flavio Luciano Ribichini

Erschienen in: Cardiovascular Toxicology | Ausgabe 6/2019

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Abstract

Diagnosis and management of Cancer therapeutics-related cardiac dysfunction is of crucial importance in breast cancer (BC) patients. The role of advanced echocardiographic techniques, such as deformation imaging, in the diagnosis and characterization of patients receiving cancer therapy has so far involved relatively small studies in the research setting. Therefore, we conducted a meta-analysis and systematic review of observational studies evaluating myocardial changes during chemotherapy detected through conventional echocardiographic parameters, such as 2D left ventricular ejection fraction (2D LVEF), and 2D Speckle tracking echocardiography (STE). The literature search retrieved 487 research works, articles, of which 17 were found to be pertinent with this topic. After full article review, 16 studies were considered suitable for the present analysis. Two separate analyses, one for the anthracyclines-based therapeutic regimen and one for the trastuzumab based therapeutic regimen, were performed. A significant reduction in 2D LVEF and 2D STE parameters during cancer therapy was found in both the investigations. Peak systolic global longitudinal strain demonstrated to be the most consistent 2D STE parameter in detecting early myocardial changes among all the studies. Thus, we confirmed the role of 2D STE for the early detection of myocardial damage, suggesting its crucial role in monitoring BC patients and eventually driving the introduction of cardioprotective treatment.

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Sant, M., Allemani, C., Santaquilani, M., Knijn, A., Marchesi, F., Capocaccia, R., et al. (2009). EUROCARE-4. Survival of cancer patients diagnosed in 1995–1999. Results and commentary. European Journal of Cancer, 45(6), 931–991. https://doi.org/10.1016/j.ejca.2008.11.018.CrossRefPubMed

Bird, B. R., & Swain, S. M. (2008). Cardiac toxicity in breast cancer survivors: Review of potential cardiac problems. Clinical Cancer Research, 14(1), 14–24. https://doi.org/10.1158/1078-0432.CCR-07-1033.CrossRefPubMed

Miller, K. D., Siegel, R. L., Lin, C. C., Mariotto, A. B., Kramer, J. L., Rowland, J. H., et al. (2016). Cancer treatment and survivorship statistics. CA: A Cancer Journal for Clinicians, 66(4), 271–289. https://doi.org/10.3322/caac.21349.CrossRef

Jensen, B. V., Skovsgaard, T., & Nielsen, S. L. (2002). Functional monitoring of anthracycline cardiotoxicity: A prospective, blinded, long-term observational study of outcome in 120 patients. Annals of Oncology, 13(5), 699–709.CrossRef

Stokke, T. M., Hasselberg, N. E., Smedsrud, M. K., Sarvari, S. I., Haugaa, K. H., Smiseth, O. A., et al. (2017). Geometry as a confounder when assessing ventricular systolic function: Comparison between ejection fraction and strain. Journal of the American College of Cardiology, 70(8), 942–954. https://doi.org/10.1016/j.jacc.2017.06.046.CrossRefPubMed

Sawaya, H., Sebag, I. A., Plana, J. C., Januzzi, J. L., Ky, B., Cohen, V., et al. (2011). Early detection and prediction of cardiotoxicity in chemotherapy-treated patients. The American Journal of Cardiology, 107(9), 1375–1380. https://doi.org/10.1016/j.amjcard.2011.01.006.CrossRefPubMedPubMedCentral

Thavendiranathan, P., Poulin, F., Lim, K. D., Plana, J. C., Woo, A., & Marwick, T. H. (2014). Use of myocardial strain imaging by echocardiography for the early detection of cardiotoxicity in patients during and after cancer chemotherapy: A systematic review. Journal of the American College of Cardiology, 63(25 Pt A), 2751–2768. https://doi.org/10.1016/j.jacc.2014.01.073.CrossRefPubMed

Boyd, A., Stoodley, P., Richards, D., Hui, R., Harnett, P., Vo, K., et al. (2017). Anthracyclines induce early changes in left ventricular systolic and diastolic function: A single centre study. PLoS ONE, 12(4), e0175544. https://doi.org/10.1371/journal.pone.0175544.CrossRefPubMedPubMedCentral

Cadeddu, C., Piras, A., Dessi, M., Madeddu, C., Mantovani, G., Scartozzi, M., et al. (2017). Timing of the negative effects of trastuzumab on cardiac mechanics after anthracycline chemotherapy. The International Journal of Cardiovascular Imaging, 33(2), 197–207. https://doi.org/10.1007/s10554-016-0987-9.CrossRefPubMed

10.

Cheng, K. H., Handschumacher, M. D., Assuncao, B., Sebag, I. A., Halpern, E. F., & Scherrer-Crosbie, M. (2017). Contraction timing patterns in patients treated for breast cancer before and after anthracyclines therapy. Journal of the American Society of Echocardiography, 30(5), 454–460. https://doi.org/10.1016/j.echo.2016.12.013.CrossRefPubMed

11.

Dogru, A., Cabuk, D., Sahin, T., Dolasik, I., Temiz, S., & Uygun, K. (2013). Evaluation of cardiotoxicity via speckle-tracking echocardiography in patients treated with anthracyclines. Onkologie, 36(12), 712–716. https://doi.org/10.1159/000356850.CrossRefPubMed

12.

Fallah-Rad, N., Walker, J. R., Wassef, A., Lytwyn, M., Bohonis, S., Fang, T., et al. (2011). The utility of cardiac biomarkers, tissue velocity and strain imaging, and cardiac magnetic resonance imaging in predicting early left ventricular dysfunction in patients with human epidermal growth factor receptor II-positive breast cancer treated with adjuvant trastuzumab therapy. Journal of the American College of Cardiology, 57(22), 2263–2270. https://doi.org/10.1016/j.jacc.2010.11.063.CrossRefPubMed

13.

Fei, H. W., Ali, M. T., Tan, T. C., Cheng, K. H., Salama, L., Hua, L., et al. (2016). Left ventricular global longitudinal strain in HER-2 + breast cancer patients treated with anthracyclines and trastuzumab who develop cardiotoxicity is associated with subsequent recovery of left ventricular ejection fraction. Echocardiography, 33(4), 519–526. https://doi.org/10.1111/echo.13168.CrossRefPubMed

14.

Florescu, M., Magda, L. S., Enescu, O. A., Jinga, D., & Vinereanu, D. (2014). Early detection of epirubicin-induced cardiotoxicity in patients with breast cancer. Journal of the American Society of Echocardiography, 27(1), 83–92. https://doi.org/10.1016/j.echo.2013.10.008.CrossRefPubMed

15.

Hare, J. L., Brown, J. K., Leano, R., Jenkins, C., Woodward, N., & Marwick, T. H. (2009). Use of myocardial deformation imaging to detect preclinical myocardial dysfunction before conventional measures in patients undergoing breast cancer treatment with trastuzumab. American Heart Journal, 158(2), 294–301. https://doi.org/10.1016/j.ahj.2009.05.031.CrossRefPubMed

16.

Lange, S. A., Jung, J., Jaeck, A., Hitschold, T., & Ebner, B. (2016). Subclinical myocardial impairment occurred in septal and anterior LV wall segments after anthracycline-embedded chemotherapy and did not worsen during adjuvant trastuzumab treatment in breast cancer patients. Cardiovascular Toxicology, 16(2), 193–206. https://doi.org/10.1007/s12012-015-9328-9.CrossRefPubMed

17.

Mele, D., Malagutti, P., Indelli, M., Ferrari, L., Casadei, F., Da Ros, L., et al. (2016). Reversibility of left ventricle longitudinal strain alterations induced by adjuvant therapy in early breast cancer patients. Ultrasound in Medicine and Biology, 42(1), 125–132. https://doi.org/10.1016/j.ultrasmedbio.2015.09.008.CrossRefPubMed

18.

Negishi, K., Negishi, T., Hare, J. L., Haluska, B. A., Plana, J. C., & Marwick, T. H. (2013). Independent and incremental value of deformation indices for prediction of trastuzumab-induced cardiotoxicity. Journal of the American Society of Echocardiography, 26(5), 493–498. https://doi.org/10.1016/j.echo.2013.02.008.CrossRefPubMed

19.

Santoro, C., Arpino, G., Esposito, R., Lembo, M., Paciolla, I., Cardalesi, C., et al. (2017). 2D and 3D strain for detection of subclinical anthracycline cardiotoxicity in breast cancer patients: A balance with feasibility. European Heart Journal-Cardiovascular Imaging, 18(8), 930–936. https://doi.org/10.1093/ehjci/jex033.CrossRefPubMed

20.

Stoodley, P. W., Richards, D. A., Boyd, A., Hui, R., Harnett, P. R., Meikle, S. R., et al. (2013). Left ventricular systolic function in HER2/neu negative breast cancer patients treated with anthracycline chemotherapy: A comparative analysis of left ventricular ejection fraction and myocardial strain imaging over 12 months. European Journal of Cancer, 49(16), 3396–3403. https://doi.org/10.1016/j.ejca.2013.06.046.CrossRefPubMed

21.

Stoodley, P. W., Richards, D. A., Hui, R., Boyd, A., Harnett, P. R., Meikle, S. R., et al. (2011). Two-dimensional myocardial strain imaging detects changes in left ventricular systolic function immediately after anthracycline chemotherapy. European Journal of Echocardiography, 12(12), 945–952. https://doi.org/10.1093/ejechocard/jer187.CrossRefPubMed

22.

Tang, Q., Jiang, Y., Xu, Y., & Xia, H. (2017). Speckle tracking echocardiography predicts early subclinical anthracycline cardiotoxicity in patients with breast cancer. Journal of Clinical Ultrasound, 45(4), 222–230. https://doi.org/10.1002/jcu.22434.CrossRefPubMed

23.

Toufan, M., Pourafkari, L., Ghahremani Nasab, L., Esfahani, A., Sanaat, Z., Nikanfar, A., et al. (2017). Two-dimensional strain echocardiography for detection of cardiotoxicity in breast cancer patients undergoing chemotherapy. Journal of Cardiovascular and Thoracic Research, 9(1), 29–34. https://doi.org/10.15171/jcvtr.2017.04.CrossRefPubMedPubMedCentral

24.

Sawaya, H., Sebag, I. A., Plana, J. C., Januzzi, J. L., Ky, B., Tan, T. C., et al. (2012). Assessment of echocardiography and biomarkers for the extended prediction of cardiotoxicity in patients treated with anthracyclines, taxanes, and trastuzumab. Circulation: Cardiovascular Imaging, 5(5), 596–603. https://doi.org/10.1161/CIRCIMAGING.112.973321.CrossRef

25.

Cardinale, D., Colombo, A., Bacchiani, G., Tedeschi, I., Meroni, C. A., Veglia, F., et al. (2015). Early detection of anthracycline cardiotoxicity and improvement with heart failure therapy. Circulation, 131(22), 1981–1988. https://doi.org/10.1161/CIRCULATIONAHA.114.013777.CrossRef

26.

Slamon, D., Eiermann, W., Robert, N., Pienkowski, T., Martin, M., Press, M., et al. (2011). Adjuvant trastuzumab in HER2-positive breast cancer. The New England Journal of Medicine, 365(14), 1273–1283.CrossRef

27.

Thavendiranathan, P., Grant, A. D., Negishi, T., Plana, J. C., Popovic, Z. B., & Marwick, T. H. (2013). Reproducibility of echocardiographic techniques for sequential assessment of left ventricular ejection fraction and volumes: Application to patients undergoing cancer chemotherapy. Journal of the American College of Cardiology, 61(1), 77–84. https://doi.org/10.1016/j.jacc.2012.09.035.CrossRefPubMed

28.

Farsalinos, K. E., Daraban, A. M., Unlu, S., Thomas, J. D., Badano, L. P., & Voigt, J. U. (2015). Head-to-head comparison of global longitudinal strain measurements among nine different vendors: The EACVI/ASE inter-vendor comparison study. Journal of the American Society of Echocardiography, 28(10), 1171–1181. https://doi.org/10.1016/j.echo.2015.06.011.CrossRefPubMed

29.

Potter, E., & Marwick, T. H. (2018). Assessment of left ventricular function by echocardiography: The case for routinely adding global longitudinal strain to ejection fraction. JACC Cardiovascular Imaging, 11(2 Pt 1), 260–274. https://doi.org/10.1016/j.jcmg.2017.11.017.CrossRefPubMed

30.

Sarvari, S. I., Haugaa, K. H., Zahid, W., Bendz, B., Aakhus, S., Aaberge, L., et al. (2013). Layer-specific quantification of myocardial deformation by strain echocardiography may reveal significant CAD in patients with non-ST-segment elevation acute coronary syndrome. JACC Cardiovascular Imaging, 6(5), 535–544. https://doi.org/10.1016/j.jcmg.2013.01.009.CrossRefPubMed

31.

Smiseth, O. A., Torp, H., Opdahl, A., Haugaa, K. H., & Urheim, S. (2016). Myocardial strain imaging: how useful is it in clinical decision making? European Heart Journal, 37(15), 1196–1207. https://doi.org/10.1093/eurheartj/ehv529.CrossRefPubMed

32.

Geyer, H., Caracciolo, G., Abe, H., Wilansky, S., Carerj, S., Gentile, F., et al. (2010). Assessment of myocardial mechanics using speckle tracking echocardiography: Fundamentals and clinical applications. Journal of the American Society of Echocardiography, 23(4), 351–369. https://doi.org/10.1016/j.echo.2010.02.015. quiz 453–355.CrossRefPubMed

33.

Mor-Avi, V., Lang, R. M., Badano, L. P., Belohlavek, M., Cardim, N. M., Derumeaux, G., et al. (2011). Current and evolving echocardiographic techniques for the quantitative evaluation of cardiac mechanics: ASE/EAE consensus statement on methodology and indications endorsed by the Japanese Society of Echocardiography. European Journal of Echocardiography, 12(3), 167–205. https://doi.org/10.1093/ejechocard/jer021.CrossRefPubMed

34.

Ng, A. C., Delgado, V., Bertini, M., Antoni, M. L., van Bommel, R. J., van Rijnsoever, E. P., et al. (2011). Alterations in multidirectional myocardial functions in patients with aortic stenosis and preserved ejection fraction: A two-dimensional speckle tracking analysis. European Heart Journal, 32(12), 1542–1550. https://doi.org/10.1093/eurheartj/ehr084.CrossRefPubMed

35.

Ho, E., Brown, A., Barrett, P., Morgan, R. B., King, G., Kennedy, M. J., et al. (2010). Subclinical anthracycline- and trastuzumab-induced cardiotoxicity in the long-term follow-up of asymptomatic breast cancer survivors: A speckle tracking echocardiographic study. Heart, 96(9), 701–707. https://doi.org/10.1136/hrt.2009.173997.CrossRefPubMed

36.

Rosen, B. D., Edvardsen, T., Lai, S., Castillo, E., Pan, L., Jerosch-Herold, M., et al. (2005). Left ventricular concentric remodeling is associated with decreased global and regional systolic function: The Multi-Ethnic Study of Atherosclerosis. Circulation, 112(7), 984–991. https://doi.org/10.1161/CIRCULATIONAHA104.500488.CrossRefPubMed

37.

Perel, R. D., Slaughter, R. E., & Strugnell, W. E. (2006). Subendocardial late gadolinium enhancement in two patients with anthracycline cardiotoxicity following treatment for Ewing’s sarcoma. Journal of Cardiovascular Magnetic Resonance, 8(6), 789–791. https://doi.org/10.1080/10976640600737664.CrossRefPubMed

38.

Zamorano, J. L., Lancellotti, P., Rodriguez Munoz, D., Aboyans, V., Asteggiano, R., Galderisi, M., et al. (2017). 2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines: The Task Force for cancer treatments and cardiovascular toxicity of the European Society of Cardiology (ESC). European Heart Journal, 19(1), 9–42. https://doi.org/10.1002/ejhf.654.CrossRef

Titel: Role of Speckle Tracking Echocardiography in the Evaluation of Breast Cancer Patients Undergoing Chemotherapy: Review and Meta-analysis of the Literature
verfasst von: Corinna Bergamini
Giulia Dolci
Stella Truong
Luisa Zanolla
Giovanni Benfari
Elena Fiorio
Andrea Rossi
Flavio Luciano Ribichini
Publikationsdatum: 02.05.2019
Verlag: Springer US
Erschienen in: Cardiovascular Toxicology / Ausgabe 6/2019
Print ISSN: 1530-7905
Elektronische ISSN: 1559-0259
DOI: https://doi.org/10.1007/s12012-019-09523-y

Springer Medizin

Abstract

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