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Immunologic Research

Erschienen in:

26.05.2018 | Review

Role of T cell-derived exosomes in immunoregulation

verfasst von: Jian Lu, Jing Wu, Jie Tian, Shengjun Wang

Erschienen in: Immunologic Research | Ausgabe 3/2018

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Abstract

Exosomes are small membrane vesicles of endocytic origin that are secreted by most cells. They are composed of a lipid bilayer containing transmembrane proteins and enclosing cytosolic proteins and RNA, mediating intercellular communication between different cell types in the body, and thus influencing various physiological and pathological functions of both recipient and parent cells. For their nanolevel structures with a stable nature and various biological functions, studies of exosomes have been the subject of increasing interest in the past few years. It is widely known that different T cell subsets play important roles in cellular and humoral immunity, and their exosomes were also reported to exert similar biological functions. While several groups reported the secretion of exosomes by various T cells, the systematic summary involved in these exosomes are deficient. In this review, we will summarize the structure and functions of exosomes derived from T cells in recent reports, discuss emerging therapeutic opportunities, and consider the associated challenges.

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Titel: Role of T cell-derived exosomes in immunoregulation
verfasst von: Jian Lu
Jing Wu
Jie Tian
Shengjun Wang
Publikationsdatum: 26.05.2018
Verlag: Springer US
Erschienen in: Immunologic Research / Ausgabe 3/2018
Print ISSN: 0257-277X
Elektronische ISSN: 1559-0755
DOI: https://doi.org/10.1007/s12026-018-9000-0

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Springer Medizin

Role of T cell-derived exosomes in immunoregulation

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Intrakapsuläre Tonsillektomie gewinnt an Boden

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