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Journal of Assisted Reproduction and Genetics

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04.05.2020 | Reproductive physiology and disease

Role of the superior ovarian nerve in the regulation of follicular development and steroidogenesis in the morning of diestrus 1

verfasst von: Deyra A. Ramírez Hernández, Elizabeth Vieyra Valdez, Gabriela Rosas Gavilán, Rosa Linares Culebro, Julieta A. Espinoza Moreno, Andrea Chaparro Ortega, Roberto Domínguez Casalá, Leticia Morales-Ledesma

Erschienen in: Journal of Assisted Reproduction and Genetics | Ausgabe 6/2020

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Abstract

Purpose

Little is known about the role of the superior ovarian nerve (SON) in follicular development during the estrus cycle. The aim of the present study was to analyze the role of neural signals arriving through the SON at the ovaries in the regulation of follicular development and ovarian steroid secretion in diestrus 1 of cyclic rats.

Methods

Cyclic rats were subjected to left, right, or bilateral SON sectioning or to unilateral or bilateral laparotomy at diestrus 1 at 11:00 h. Animals were sacrificed 24 h after surgery.

Results

Compared to laparotomized animals, unilateral SON sectioning decreased the number of preovulatory follicles, while bilateral SON sectioning resulted in a decreased number of atretic preantral follicles. An important observation was the presence of invaginations in the follicular wall of large antral and preovulatory follicles in animals with denervation. Furthermore, left SON sectioning increased progesterone levels but decreased testosterone levels, which are effects that were not observed in animals that were subjected to right denervation.

Conclusions

At 11:00 h of diestrus 1, the SON was found to stimulate follicle development, possibly via neural signals, such as noradrenaline and/or vasoactive intestinal peptide, and this stimulation induced the formation of follicle-stimulating hormone receptors. The role of the SON in the regulation of ovarian steroid secretion is asymmetric: the left SON inhibits the regulation of progesterone and stimulates testosterone secretion, and the right nerve does not participate in these processes.

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Titel: Role of the superior ovarian nerve in the regulation of follicular development and steroidogenesis in the morning of diestrus 1
verfasst von: Deyra A. Ramírez Hernández
Elizabeth Vieyra Valdez
Gabriela Rosas Gavilán
Rosa Linares Culebro
Julieta A. Espinoza Moreno
Andrea Chaparro Ortega
Roberto Domínguez Casalá
Leticia Morales-Ledesma
Publikationsdatum: 04.05.2020
Verlag: Springer US
Erschienen in: Journal of Assisted Reproduction and Genetics / Ausgabe 6/2020
Print ISSN: 1058-0468
Elektronische ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-020-01787-6

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Role of the superior ovarian nerve in the regulation of follicular development and steroidogenesis in the morning of diestrus 1

Abstract

Purpose

Methods

Results

Conclusions

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Abstract

Purpose

Methods

Results

Conclusions

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