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22.02.2020 | Review

Role of the tumor microenvironment in regulating the anti-metastatic effect of KISS1

verfasst von: Sitaram Harihar, Srijit Ray, Samyukta Narayanan, Anirudh Santhoshkumar, Thuc Ly, Danny R. Welch

Erschienen in: Clinical & Experimental Metastasis | Ausgabe 2/2020

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Abstract

KISS1, a metastasis suppressor gene, has been shown to block metastasis without affecting primary tumor formation. Loss of KISS1 leads to invasion and metastasis in multiple cancers, which is the leading cause of cancer morbidity and mortality. The discovery of KISS1 has provided a ray of hope for early clinical diagnosis and for designing effective treatments targeting metastatic cancer. However, this goal requires greater holistic understanding of its mechanism of action. In this review, we go back into history and highlight some key developments, from the discovery of KISS1 to its role in regulating multiple physiological processes including cancer. We discuss key emerging roles for KISS1, specifically interactions with tissue microenvironment to promote dormancy and regulation of tumor cell metabolism, acknowledged as some of the key players in tumor progression and metastasis. We finally discuss strategies whereby KISS1 might be exploited clinically to treat metastasis.
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Metadaten
Titel
Role of the tumor microenvironment in regulating the anti-metastatic effect of KISS1
verfasst von
Sitaram Harihar
Srijit Ray
Samyukta Narayanan
Anirudh Santhoshkumar
Thuc Ly
Danny R. Welch
Publikationsdatum
22.02.2020
Verlag
Springer Netherlands
Erschienen in
Clinical & Experimental Metastasis / Ausgabe 2/2020
Print ISSN: 0262-0898
Elektronische ISSN: 1573-7276
DOI
https://doi.org/10.1007/s10585-020-10030-6

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