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Journal of Clinical Immunology

Erschienen in:

01.06.2011

Role of Thymic Stromal Lymphopoietin (TSLP) in Palifermin-Mediated Immune Modulation and Protection from Acute Murine Graft-Versus-Host Disease

verfasst von: Cynthia A. Ellison, Yuriy V. Lissitsyn, Juliet A. Packiasamy, Warren J. Leonard, John G. Gartner

Erschienen in: Journal of Clinical Immunology | Ausgabe 3/2011

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Abstract

Using the C57BL/6→(C57BL/6 x DBA/2)F₁-hybrid model of acute graft-versus-host disease (GVHD), we previously showed that treating the donor mice with palifermin provides protection from morbidity and a shift from Th1 to Th2 cytokine production. To determine whether thymic stromal lymphopoietin (TSLP) is involved in palifermin-mediated immune modulation, we used donors from the following groups: (1) untreated wild-type donors, (2) palifermin-treated wild-type donors, (3) untreated TSLPR^−/− donors, and (4) palifermin-treated TSLPR^−/− donors. Survival in the recipients was 0%, 100%, 31%, and 0%, for groups 1–4, respectively, indicating that TSLP responsiveness is required for palifermin-mediated protection from GVHD. We also found that the increases in Th2 cytokine levels that are induced by palifermin treatment are obviated in TSLPR^−/− donors, and that protection from GVHD (group 2) is associated with a higher percentage of CD4⁺CD25⁺Foxp3⁺ cells in the graft. Collectively, our findings show that when palifermin and TSLP act in concert, the predominant effect is protection in this model.

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Titel: Role of Thymic Stromal Lymphopoietin (TSLP) in Palifermin-Mediated Immune Modulation and Protection from Acute Murine Graft-Versus-Host Disease
verfasst von: Cynthia A. Ellison
Yuriy V. Lissitsyn
Juliet A. Packiasamy
Warren J. Leonard
John G. Gartner
Publikationsdatum: 01.06.2011
Verlag: Springer US
Erschienen in: Journal of Clinical Immunology / Ausgabe 3/2011
Print ISSN: 0271-9142
Elektronische ISSN: 1573-2592
DOI: https://doi.org/10.1007/s10875-010-9491-5

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Role of Thymic Stromal Lymphopoietin (TSLP) in Palifermin-Mediated Immune Modulation and Protection from Acute Murine Graft-Versus-Host Disease

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