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Anatomical Science International

Erschienen in:

01.01.2015 | Review Article

Roles of lipid-modulating enzymes diacylglycerol kinase and cyclooxygenase under pathophysiological conditions

verfasst von: Tomoyuki Nakano

Erschienen in: Anatomical Science International | Ausgabe 1/2015

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Abstract

Lipid not only represents a constituent of the plasma membrane, but also plays a pivotal role in intracellular signaling. Lipid-mediated signaling system is strictly regulated by several enzymes, which act at various steps of the lipid metabolism. Under pathological conditions, prolonged or insufficient activation of this system results in dysregulated signaling, leading to diseases such as cancer or metabolic syndrome. Of the lipid-modulating enzymes, diacylglycerol kinase (DGK) and cyclooxygenase (COX) are intimately involved in the signaling system. DGK consists of a family of enzymes that phosphorylate a second messenger diacylglycerol (DG) to produce phosphatidic acid (PA). Both DG and PA are known to activate signaling molecules such as protein kinase C. COX catalyzes the committed step in prostanoid biosynthesis, which involves the metabolism of arachidonic acid to produce prostaglandins. Previous studies have shown that the DGK and COX are engaged in a number of pathological conditions. This review summarizes the functional implications of these two enzymes in ischemia, liver regeneration, vascular events, diabetes, cancer and inflammation.

Akiyama H, Hozumi Y, Nakano T, Kubota I, Goto K (2011) Nuclear relocation of DGKζ in cardiomyocytes under condition of ischemia/reperfusion. Histol Histopathol 26:1383–1390PubMed

Alhouayek M, Muccioli GG (2014) COX-2-derived endocannabinoid metabolites as novel inflammatory mediators. Trends Pharmacol Sci 35:284–292PubMedCrossRef

Ali H, Nakano T, Saino-Saito S, Hozumi Y, Katagiri Y, Kamii H, Sato S, Kayama T, Kondo H, Goto K (2004) Selective translocation of diacylglycerol kinase ζ in hippocampal neurons under transient forebrain ischemia. Neurosci Lett 372:190–195PubMedCrossRef

Alison MR (1986) Regulation of hepatic growth. Physiol Rev 66:499–541PubMed

Avila-Flores A, Santos T, Rincón E, Mérida I (2005) Modulation of the mammalian target of rapamycin pathway by diacylglycerol kinase-produced phosphatidic acid. J Biol Chem 280:10091–10099PubMedCrossRef

Awasthi V, King RJ (2000) PKC, p45/p44 MAPK, and p38 MAPK are required for HGF-induced proliferation of H441 cells. Am J Physiol Lund Cell Mol Physiol 279:L942–L949

Bagi Z, Erdei N, Toth A, Li W, Hintze TH, Koller A, Kaley G (2005) Type 2 diabetic mice have increased arteriolar tone and blood pressue enhanced release of COX-2-derived constrictor prostaglandin. Arterioscler Thromb Vasc Biol 25:1610–1616PubMedCrossRef

Baldanzi G, Pietronave S, Locarno D, Merlin S, Porporato P, Chianale F, Filigheddu N, Cantelomo AR, Albini A, Graziani A, Prat M (2011) Diacylglycerol kinases are essential for hepatocyte growth factor-dependent proliferation and motility of Kaposi’s sarcoma cells. Cancer Sci 102:1329–1336PubMedCrossRef

Brenner CR, Galluzzi L, Kepp O, Kroemer G (2013) Decoding cell death signals in liver inflammation. J Hepatol 59:583–594PubMedCrossRef

Camacho M, Dilmé J, Solà-Villà D, Rodríguez C, Bellmunt S, Siguero L, Alcolea S, Romero JM, Escudero JR, Martínez-González J, Vila L (2013) Microvascular COX-2/mPGES-1/EP-4 axis in human abdominal aortic aneurysm. J Lipid Res 54:3506–3515PubMedCentralPubMedCrossRef

Candelario-Jalil E, González-Falcón A, García-Cabrera M, Alvarez D, Al-Dalain S, Martínez G, León OS, Springer JE (2003) Assessment of the relative contribution of COX-1 and COX-2 isoforms to ischemia-induced oxidative damage and neurodegeneration following transient global cerebral ischemia. J Neurochem 86:545–555PubMedCentralPubMedCrossRef

Casado M, Callejas NA, Rodrigo J, Zhao X, Dey SK, Boscá L, Martín-Sanz P (2001) Contribution of cyclooxygenase-2 to liver regeneration after partial hepatectomy. FASEB J 15:2016–2018PubMed

Chibalin AV, Leng Y, Vieira E, Krook A, Björnholm M, Long YC, Kotova O, Zhong Z, Sakane F, Steiler T, Nylén C, Wang J, Laakso M, Topham MK, Gilbert M, Wallberg-Henriksson H, Zierath JR (2008) Downregulation of diacylglycerol kinase δ contributes thyperglycemia-induced insulin resistance. Cell 132:375–386PubMedCrossRef

Collin de l’Hortet A, Gilgenkrants H, Guidotti JE (2012) EGFR: a master piece in G1/S phase transition of liver regeneration. Int J Hepatol 2012:476910

Crotty TM, Nakano T, Stafforini DM, Topham MK (2012) Diaclyglycerol kinase δ modulates Akt phosphorylation through pleckstrin homology domain leucine-rich repeat protein phosphatase 2 (PHLPP2). J Biol Chem 288:1439–1447PubMedCentralPubMedCrossRef

Dohadwala M, Yang SC, Luo J, Sharma S, Batra RK, Huang M, Lin Y, Goodglick L, Krysan K, Fishbein MC, Hong L, Lai C, Cameron RB, Gemmill RM, Drabkin HA, Dubinett SM (2006) Cyclooxygenase-2-dependent regulation of E-cadherin: prostaglandin E₂ induces transcriptional repressors ZEB1 and snail in non-small cell lung cancer. Cancer Res 66:5338–5345PubMedCrossRef

Dolley G, Lamarche B, Després JP, Bouchard C, Pérusse L, Vohl MC (2009) Phosphoinositide cycle gene polymorphisms affect the plasma lipid profile in the Quebec Family Study. Mol Genet Metab 97:149–154PubMedCrossRef

Fabbro D, Küng W, Roos W, Regazzi R, Eppenberger U (1986) Epidermal growth factor binding and protein kinase C activities in human breast cancer cell lines: possible quantitative relationship. Cancer Res 46:2720–2725PubMed

Fawcett JW, Rosser AE, Dunnett SB (2001) Brain damage, brain repair. Oxford University Press, Oxford

Feletou M, Huang Y, Vanhoutte PM (2011) Endothelium-mediated control of vascular tone: COX-1 and COX-2 products. Br J Pharmacol 164:894–912PubMedCentralPubMedCrossRef

Fernández-Martínez A, Callejas NA, Casado M, Boscá L, Martín-Sanz P (2004) Thioacetamide-induced liver regeneration involves the expression of cyclooxygenase 2 and nitric oxide synthase 2 in hepatocytes. J Hepatol 40:963–970PubMedCrossRef

Fetalvero KM, Martin KA, Hwa J (2007) Cardioprotective prostacyclin signaling in vascular smooth muscle. Prostaglandins Other Lipid Mediat 82:109–118PubMedCrossRef

Ganju A, Yallapu MM, Khan S, Behrman SW, Chauhan SC, Jaggi M (2014) Nanoways to overcome docetaxel resistance in prostate cancer. Drug Resist Updat 17:13–23PubMedCrossRef

Goss JA, Mangino MJ, Callery MP, Flye MW (1993) Prostaglandin E₂ downregulates Kupffer cell production of IL-1 and IL-6 during hepatic regeneration. Am J Physiol 264:G601–G608PubMed

Goto K, Watanabe M, Kondo H, Yuasa H, Sakane F, Kanoh H (1992) Gene cloning, sequencing, expression and in situ localization of 80 kDa diacylglycerol kinase specific to oligodendrocyte of rat brain. Brain Res Mol Brain Res 16:75–87PubMedCrossRef

Goto K, Nakano T, Hozumi Y (2006) Diacylglycerol kinase and animal models: the pathophysiological roles in the brain and heart. Adv Enzyme Regul 46:192–202PubMedCrossRef

Goto K, Hozumi Y, Nakano T, Saino-Saito S, Kondo H (2007) Cell biology and pathophysiology of the diacylglycerol kinase family: morphological aspects intissues and organs. Int Rev Cytol 264:25–63PubMedCrossRef

Goto K, Tanaka T, Nakano T, Okada M, Hozumi Y, Topham MK, Martelli AM (2013) DGKζ under stress conditions: “to be nuclear or cytoplasmic, that is the question”. Adv Biol Regul 54:242–253CrossRef

Guo Z, Su W, Allen S, Pang H, Daugherty A, Smart E, Gong MC (2005) COX-2 up-regulation and vascular smooth muscle contractile hyperreactivity in spontaneous diabetic db/db mice. Cardiovasc Res 67:723–735PubMedCrossRef

Hasegawa H, Nakano T, Hozumi Y, Takagi M, Ogino T, Okada M, Kondo H, Watanabe M, Martelli AM, Goto K (2008) Diacylglycerol kinase ζ is associated with chromatin, but dissociates from condensed chromatin during mitotic phase in NIH3T3 cells. J Cell Biochem 105:756–765PubMedCrossRef

Henkel J, Neuschäfer-Rube F, Pathe-Neuschäfer-Rube A, Püschel GP (2009) Aggravation by prostaglandin E₂ of interleukin-6-dependent insulin resistance in hepatocyte. Hepatology 50:781–790PubMedCrossRef

Henkel J, Frede K, Schanze N, Vogel H, Schürmann A, Spruss A, Bergheim I, Püschel GP (2012) Stimulation of fat accumulation in hepatocytes by PGE₂-dependent repression of hepatic lipolysis, β-oxidation and VLDL-synthesis. Lab Invest 92:1597–1606PubMedCrossRef

Hozumi Y, Ito T, Nakano T, Nakagawa T, Aoyagi M, Kondo H, Goto K (2003) Nuclear localization of diacylglycerol kinase ζ in neurons. Eur J Neurosci 18:1448–1457PubMedCrossRef

Huang Y, Zhang H, Shao Z, O’Hara KA, Kopilas MA, Yu L, Netticadan T, Anderson HD (2011) Suppression of endothelin-1-induced cardiac myocyte hypertrophy by PPAR agonists: role of diacylglycerol kinase ζ. Cardiovasc Res 90:267–275PubMedCrossRef

Iadecola C, Niwa K, Nogawa S, Zhao X, Nagayama M, Araki E, Morham S, Ross ME (2001) Reduced susceptibility to ischemic brain injury and N-methyl-D-aspartate-mediated neurotoxicity in cyclooxygenase-2-deficient mice. Proc Natl Acad Sci USA 98:1294–1299PubMedCentralPubMedCrossRef

Idborg H, Pawelzik SC, Perez-Manso M, Björk L, Hamrin J, Herlenius E, Jakobsson PJ (2014) Evaluation of urinary prostaglandin E₂ metabolite as a marker in infants with fever due to viral infection. Prostaglandins Leukot Essent Fatty Acids. doi:10.1016/j.plefa.2014.09.006

Irie T, Tsujii M, Tsuji S, Yoshio T, Ishii S, Shinzaki S, Egawa S, Kakiuchi Y, Nishida T, Yasumaru M, Iijima H, Murata H, Takehara T, Kawano S, Hayashi N (2007) Synergistic antitumor effects of celecoxib with 5-fluorouracil depend on IFN-γ. Int J Cancer 121:878–883PubMedCrossRef

Ji B, Kumata K, Onoe H, Kaneko H, Zhang MR, Seki C, Ono M, Shukuri M, Tokunaga M, Minamihisamatsu T, Suhara T, Higuchi M (2013) Assessment of radioligands for PET imaging of cyclooxygenase-2 in an ischemic neuronal injury model. Brain Res 1533:152–162PubMedCrossRef

Katagiri Y, Ito T, Saino-Saito S, Hozumi Y, Suwabe A, Otake K, Sata M, Kondo H, Sakane F, Kanoh H, Kubota I, Goto K (2005) Expression and localization of diacylglycerol kinase isozymes and enzymatic features in rat lung. Am J Physiol Lung Cell Mol Physiol 288:L1171–L1178PubMedCrossRef

Kirino T (1982) Delayed neuronal death in the gerbil hippocampus following ischemia. Brain Res 239:57–69PubMedCrossRef

Kirkby NS, Zaiss AK, Urquhart P, Jiao J, Austin PJ, Al-Yamani M, Lundberg MH, MacKenzie LS, Warner TD, Nicolaou A, Herschman HR, Mitchell JA (2013) LC-MS/MS confirms that COX-1 drives vascular prostacyclin whilst gene expression pattern reveals non-vascular sites of COX-2 expression. PLoS One 8:e69524PubMedCentralPubMedCrossRef

Kobayashi T, Tahara Y, Matsumoto M, Iguchi M, Sano H, Murayama T, Arai H, Oida H, Yurugi-Kobayashi T, Yamashita JK, Katagiri H, Majima M, Yokode M, Kita T, Narumiya S (2004) Roles of thromboxane A₂ and prostacyclin in the development of atherosclerosis in apoE-deficient mice. J Clin Invest 114:784–794PubMedCentralPubMedCrossRef

Li W, Wu S, Ahmad M, Jiang J, Liu H, Nagayama T, Rose ME, Tyurin VA, Tyurina YY, Borisenko GG, Belikova N, Chen J, Kagan VE, Graham SH (2010) The cyclooxygenase site, but not the peroxidase site of cyclooxygenase-2 is required for neurotoxicity in hypoxic and ischemic injury. J Neurochem 113:965–977PubMedCentralPubMedCrossRef

Lobo Prabhu KC, Vu L, Chan SK, Phang T, Gown A, Jones SJ, Wiseman SM (2014) Predictive utility of cyclo-oxygenase-2 expression by colon and rectal cancer. Am J Surg 207:712–716PubMedCrossRef

Lukiw WJ, Cui JG, Musto AE, Musto BC, Bazan NG (2005) Epileptogenesis in diacylglycerol kinase ε deficiency up-regulates COX-2 and tyrosine hydroxylase in hippocampus. Biochem Biophys Res Commun 338:77–81PubMedCrossRef

Martín-Sanz P, Mayoral R, Casado M, Boscá L (2010) COX-2 in liver, from regeneration to hepatocarcinogenesis: what we have learned from animal model? World J Gastroentel 16:1430–1435CrossRef

Marumo M, Nakano T, Takeda Y, Goto K, Wakabayashi I (2012) Inhibition of thrombin-induced Ca²⁺ influx in platelets by R59949, an inhibitor of diacylglycerol kinase. J Pharm Pharmacol 64:855–861PubMedCrossRef

Michalopoulos GK, DeFrances MC (1997) Liver regeneration. Science 276:60–66PubMedCrossRef

Munir MS, Wang Z, Alahdab F, Steffen MW, Erwin PJ, Kullo IJ, Murad MH (2014) The association of 9p21-3 locus with coronary atherosclerosis: a systematic review and meta-analysis. BMC Med Genet 15:66PubMedCentralPubMedCrossRef

Nakamura H, Murayama T (2014) The role of sphingolipids in arachidonic acid metabolism. J Pharmacol Sci 124:307–312PubMedCrossRef

Nakano T, Wakabahashi I (2010) Identification of cells expressing cyclooxygenase-2 in response to interleukin-1β in rat aortae. J Pharmacol Sci 113:84–88PubMedCrossRef

Nakano T, Hozumi Y, Ali H, Saino-Saito S, Kamii H, Sato S, Kayama T, Watanabe M, Kondo H, Goto K (2006) Diacylglycerol kinase ζ is involved in the process of cerebral infarction. Eur J Neurosci 23:1427–1435PubMedCrossRef

Nakano T, Hozumi Y, Goto K, Wakabayashi I (2009a) Localization of diacylglycerol kinase ε on stress fibers in vascular smooth muscle cell. Cell Tissue Res 337:167–175PubMedCrossRef

Nakano T, Iseki K, Hozumi Y, Kawamae K, Wakabayashi I, Goto K (2009b) Brain trauma induces expression of diacylglycerol kinase ζ in microglia. Neurosci Lett 461:110–115PubMedCrossRef

Nakano T, Goto K, Wakabayashi I (2011) Docetaxel inhibits cyclooxygenase-2 induction in vascular smooth muscle cells. Eur J Pharmacol 654:150–154PubMedCrossRef

Nakano T, Hozumi Y, Goto K, Wakabayashi I (2012a) Involvement of diacylglycerol kinase γ in modulation of iNOS synthesis in Golgi apparatus of vascular endothelial cells. Nauryn-Schmiedeberg’s Arch Pharmacol 385:787–795CrossRef

Nakano T, Hozumi Y, Iwazaki K, Iseki K, Saito T, Kawata S, Wakabayashi I, Goto K (2012b) Altered expression of diacylglycerol kinase isozymes in regenerating liver. J Histochem Cytochem 60:130–138PubMedCentralPubMedCrossRef

Nakano T, Iravani A, Kim M, Hozumi Y, Lohse M, Reichert E, Crotty TM, Stafforini DM, Topham MK (2014) Diacylglycerol kinase η modulates oncogenic properties of lung cancer cells. Clin Transl Oncol 16:29–35PubMedCentralPubMedCrossRef

Nakayama M, Uchimura K, Zhu RL, Nagayama T, Rose ME, Stetler RA, Isakson PC, Chen J, Graham SH (1998) Cyclooxygenase-2 inhibition prevents delayed death of CA1 hippocampal neurons following global ischemia. Proc Natl Acad Sci USA 95:10954–10959PubMedCentralPubMedCrossRef

Nogawa S, Zhang F, Ross ME, Iadecola C (1997) Cyclo-oxygenase-2 gene expression in neurons contributes to ischemic brain damage. J Neurosci 17:2746–2755PubMed

Pai R, Soreghan B, Szabo IL, Meredith P, Dolgor B, Tarnawski AS (2002) Prostaglandin E₂ transactivates EGF receptor: a novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy. Nat Med 8:289–293PubMedCrossRef

Pai R, Nakamura T, Moon WS, Tarnawski AS (2003) Prostaglandins promote colon cancer cell invasion; signaling by cross-talk between two distinct growth factor receptors. FASEB J 17:1640–1647PubMedCrossRef

Park ES, Yoo J-M, Lim Y, Tudev M, Yoo H-S, Hong JT, Yun Y-P (2011) Inhibitory effects of docetaxel on platelet-derived growth factor (PDGF)-BB-induced proliferation of vascular smooth muscle cells through blocking PDGF-receptor β phosphorylation. J Pharmacol Sci 116:204–213PubMedCrossRef

Quilley J, Santos M, Pedraza P (2011) Renal protective effect of chronic inhibition of COX-2 with SC-58236 in streptozotocin-deabetic rats. Am J Physiol Heart Circ Physiol 300:H2316–H2322PubMedCentralPubMedCrossRef

Rao M, Mayor S (2014) Active organization of membrane constitutes in living cell. Curr Opin Cell Biol 29:126–132PubMedCrossRef

Reyners AK, de Munck L, Erdkamp FL, Smit WM, Hoekman K, Lalisang RI, de Graaf H, Wymenga AN, Polee M, Hollema H, van Vugt MA, Schaapveld M, Willemse PH, DoCaCel Study Group (2012) A randomized phase II study investigating the addition of the specific COX-2 inhibitor celecoxib to docetaxel plus carboplatin as first-line chemotherapy for stage IC to IV epithelial ovarian cancer, Fallopian tube or primary peritoneal carcinomas: the DoCaCel study. Ann Oncol 23:2896–2902PubMedCrossRef

Roan JN, Tsai YC, Chen IW, Chang SW, Huang CC, Lam CF (2012) Inhibition of cyclooxygenase-2 modulates phenotypic switching of vascular smooth muscle cells during increased aortic blood flow. Heart Vessels 27:307–315PubMedCrossRef

Rudnick DA, Perlmutter DH, Munlia LJ (2001) Prostaglandins are required for CREB activation and cellular proliferation during liver regeneration. Proc Natl Acad Sci USA 98:8885–8890PubMedCentralPubMedCrossRef

Saino-Saito S, Hozumi Y, Goto K (2011) Excitotoxicity by kainite-induced seizure causes diacylglycerol kinase ζ to shuttle from the nucleus to the cytoplasm in hippocampal neurons. Neurosci Lett 494:185–189PubMedCrossRef

Sakane F, Imai S, Kai M, Yasuda S, Kanoh H (2007) Diacylglycerol kinases: why so many of them? Biochim Biophys Acta 1771:793–806PubMedCrossRef

Shimamura M, Zhou P, Casolla B, Qian L, Capone C, Kurinami H, Iadecola C, Anrather J (2013) Prostaglandin E2 type 1 receptors contribute to neuronal apoptosis after transient forebrain ischemia. J Cereb Blood Flow Metab 33:1207–1214PubMedCentralPubMedCrossRef

Simmons DL, Botting RM, Timothy HLA (2004) Cyclooxygenase isozymes: the biology of prostaglandin synthesis and inhibition. Pharmacol Rev 56:387–437PubMedCrossRef

Smith JMS, Lautt WW (2005) The role of prostaglandins in triggering the liver regeneration cascade. Nitric Oxide 13:111–117CrossRef

Stemme V, Swedenborg J, Claesson H, Hansson GK (2000) Expression of cyclo-oxygenase-2 in human atherosclerotic carotid arteries. Eur J Vasc Endovasc Surg 20:146–152PubMedCrossRef

Stoll G, Jander S, Schroeter M (1998) Inflammation and glial responses in ischemic brain lesions. Prog Neurobiol 56:149–171PubMedCrossRef

Subbaramaiah K, Marmo TP, Dixon DA, Dannenberg AJ (2003) Regulation of cyclooxygenase-2 mRNA stability by taxanes: evidence for involvement of p38, MAPKAPK-2, and HuR. J Biol Chem 278:37637–37647PubMedCrossRef

Suzuki Y, Yamazaki Y, Hozumi Y, Okada M, Tanaka T, Iseki K, Ohta N, Aoyagi M (2012) NMDA receptor-mediated Ca²⁺ influx triggers nucleocytoplasmic translocation of diacylgycerol kinase ζ under oxygen-glucose deprivation conditions, an in vitro model of ischemia, in rat hippocampal slices. Histochem Cell Biol 137:499–511PubMedCrossRef

Tabassum R, Vaibhav K, Shrivastava P, Khan A, Anmed ME, Ashafaq M, Khan MB, Islam F, Safhi MM, Islam F (2014) Perillyl alcohol improves functional and histological outcomes agaist ischemia-reperfusion injury by attenuation of oxidative stress and repression of COX-2, NOS-2 and NF-kB in middle cerebral artery occlusion rats. Eur J Pharmacol S0014-2999(14):00659–00601. doi:10.1016/j.ejphar.2014.09.015

Takeuchi M, Sakiyama S, Usuki T, Sakai H, Sakane F (2012) Diacylglycerol kinase δ1 transiently translocates to the plasma membrane in response to high glucose. Biochim Biophys Acta 1823:2210–2216PubMedCrossRef

Tong X, Peng H, Liu D, Liang Ji, Niu C, Ren J, Pan B, Hu J, Zheng L, Huang Y (2013) High-density lipoprotein of patients with type 2 diabetes mellitus upregulates cycooxygnease-2 expression and prostacyclin I-2 release in endothelial cells: relationship with HDL-associated shipngosins-1-phosphate. Cardiovasc Diabetol 12:27PubMedCentralPubMedCrossRef

Toniolo A, Buccellati C, Pinna C, Gaion RM, Sala A, Bolego C (2013) Cyclooxygenase-1 and prostacyclin production by endothelial cells in the presence of mild oxidative stress. PLoS One 8:e56683PubMedCentralPubMedCrossRef

Topham MK, Epand RM (2009) Mammalian diacylglycerol kinases: molecular interactions and biological functions of selected isoform. Biochim Biophys Acta 1790:416–424PubMedCentralPubMedCrossRef

Tran PO, Gleason CE, Robertson RP (2002) Inhibition of interleukin-1β-induced COX-2 and EP3 gene expression by sodium salicylate enhances pancreatic islet β-cell function. Diabetes 51:1772–1778PubMedCrossRef

Tsujii M, Kawano S, DuBois RN (1997) Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential. Proc Natl Acad Sci USA 94:3336–3340PubMedCentralPubMedCrossRef

Tsujii M, Kawano S, Tsuji S, Sawaoka H, Hori M, DuBois RN (1998) Cyclooxygenase regulates angiogenesis induced by colon cancer cells. Cell 93:705–716PubMedCrossRef

Vaibhav K, Shrivastava P, Javed H, Khan A, Ajaz Ahmed M, Tabassum R, Moshahid Khan M, Khuwaja G, Islam F, Siddiqui MS, Safhi MM, Islam F (2012) Piperine suppresses cerebral ischemia-reperfusion-induced inflammation through the repression of COX-2, NOS-2, and NF-κB in middle cerebral artery occlusion rat model. Mol Cell Biochem 367:73–84PubMedCrossRef

Vane JR, Bakhle YS, Botting RM (1998) Cyclooxygenases 1 and 2. Annu Rev Pharmacol Toxicol 38:97–120PubMedCrossRef

Verrier E, Wang L, Wadham C, Albanese N, Hahn C, Gamble JR, Chatterjee VK, Vadas MA, Xia P (2004) PPARγ agonists ameliorate endothelial cell activation via inhibition of diacylglycerol kinase C signaling pathway: role of diacylglycerol kinase. Circ Res 94:1515–1522PubMedCrossRef

Vessières E, Guihot AL, Toutain B, Maquigneau M, Fassot C, Loufrani L, Henrion D (2013) COX-2-dereived prostanoids and oxidative stress additionally reduces endothelium-mediated relaxation in old type 2 diabetic rats. PLoS One 8:e68217PubMedCentralPubMedCrossRef

Xu K, Kitchen CM, Shu HK, Murphy TJ (2007) Platelet-derived growth factor-induced stabilization of cycloloxygenase-2 mRNA in rat aortic smooth muscle cells requires the c-Src family of protein-tyrosine kinases. J Biol Chem 282:3269–32709

Yamamoto M, Tanaka T, Hozumi Y, Saino-Saito S, Nakano T, Tajima K, Kato T, Goto K (2014) Expression of mRNAs for the diacylglycerol kinase family in immune cells during an inflammatory reactions. Biomed Res 35:61–68PubMedCrossRef

Yasuda S, Kai M, Imai S, Takeishi K, Taketomi A, Toyota M, Kanoh H, Sakane F (2009) Diacylglycerol kinase η augments C-Raf activity and B-Raf/C-Raf heterodimerization. J Biol Chem 284:29559–29570PubMedCentralPubMedCrossRef

Zhu N, Liu B, Luo W, Zhang Y, Li H, Li S, Zhou Y (2014) Vasoconstrictor role of cyclooxygenase-1-mediated prostaglandin synthesis in non-insulin-dependent diabetic mice induced by high-fat diet and streptozotocine. Am J Physiolo Heart Circ Physiol 307:H319–H327CrossRef

Titel: Roles of lipid-modulating enzymes diacylglycerol kinase and cyclooxygenase under pathophysiological conditions
verfasst von: Tomoyuki Nakano
Publikationsdatum: 01.01.2015
Verlag: Springer Japan
Erschienen in: Anatomical Science International / Ausgabe 1/2015
Print ISSN: 1447-6959
Elektronische ISSN: 1447-073X
DOI: https://doi.org/10.1007/s12565-014-0265-7

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Roles of lipid-modulating enzymes diacylglycerol kinase and cyclooxygenase under pathophysiological conditions

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