Erschienen in:
01.11.2015 | Brief Communication
rs4771122 Predicts Multiple Measures of Long-Term Weight Loss After Bariatric Surgery
verfasst von:
Laura J. Rasmussen-Torvik, Abigail S. Baldridge, Jennifer A. Pacheco, Sharon A. Aufox, Kwang-Youn A. Kim, Jonathan C. Silverstein, Erwin W. Denham, Eric Hungness, Maureen E. Smith, Philip Greenland
Erschienen in:
Obesity Surgery
|
Ausgabe 11/2015
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Abstract
We examined the association of 34 single nucleotide polymorphisms with weight loss up to 9.5 years after Roux-en-Y surgery. Participants were enrollees in the NUgene biobank with stored DNA and linked electronic health records. Ninety-five self-identified white participants underwent surgery and had follow-up weights obtained between 1 and 9.5 years after surgery. SNP rs4771122 was the variant most significantly associated with long-term weight loss after surgery in a repeated linear mixed model (p = .004) of long-term weight loss. In this model, each additional copy of the minor allele was associated with nearly 5 % greater percentage weight loss. This same SNP was also nominally significantly (p < .05) associated with weight loss trajectories, weight loss nadir, and weight loss 2 years after surgery.