Preeclampsia is a major health problem. Although, the pathophysiology of preeclampsia is not fully understood, there are recent studies on association between infections and preeclampsia.
The aim of the present study was to investigate the association between maternal seropositivity of rubella, Herpes simplex virus type 2 (HSV-2) and preeclampsia.
A case –controls study (90 women in each arm) was conducted at Saad Abualila Maternity Hospital, Khartoum, Sudan.
The cases were women with preeclampsia and the controls were healthy pregnant women. Rubella and HSV-2 IgG antibodies were analysed in the maternal sera of all of the participants using ELISA.
There was no significant difference in the age, parity and gestational age between the two groups. Maternal serum IgG seropositivity for rubella (92.2% vs. 34.4%, P < 0.001) and HSV-2 (87.8% vs. 57.8%, P < 0.001) were significantly higher in preeclampsia than in the controls. There was no significant difference in the maternal serum IgM seropositivity for rubella (3.3% vs. 2.2%, P = 0.650) and HSV-2 (2.2% vs. 1.1%, P = 0.560). All the IgM seropositive cases were IgG seropositive too. In binary logistic regression women with rubella (OR = 4.93; 95% CI = 2.082–11.692, P < 0.001) and HSV-2 (OR = 5.54; 95% CI = 2.48–12.38, P < 0.001) IgG seropositivity were at higher risk for preeclampsia.
In the current study rubella and HSV-2 IgG seropositivity is associated with preeclampsia. Preventive measure should be implemented.
American College of Obstetricians and Gynecologists. ACOG practice bulletin. Diagnosis and management of preeclampsia and eclampsia. Number 33, January 2002. American College of Obstetricians and Gynecologists. Int J Gynaecol Obstet. 2002;77:67–75. CrossRef
Abalos E, Cuesta C, Carroli G, Qureshi Z, Widmer M, Vogel JP, et al. Pre-eclampsia, eclampsia and adverse maternal and perinatal outcomes: a secondary analysis of the World Health Organization multicountry survey on maternal and newborn health. BJOG. 2014:14–24.
Zhang J, Zhang W. Relationship of cytomegalovirus, Chlamydia pneumoniae and herpes simplex virus type 2 infections with preeclampsia. Zhonghua Yi Xue Za Zhi. 2012;92:1413–5. PubMed
Ali AAA, Rayis DA, Abdallah TM, Abdullahi H, Adam I. Hypertensive disorders in pregnancy in Kassala Hospital, Eastern Sudan. Khartoum Med J. 2011;4(3):656–9.
Lao TT, Sahota DS, Law L-W, Leung T-Y. Maternal rubella immunity status and pre-eclampsia. Am J Reprod Immunol. 2017;78(1). doi: 10.1111/aji.12677. Epub 2017 Mar 30.
Trogstad LI. Eskild a, Bruu a L, Jeansson S, Jenum P a. Is preeclampsia an infectious disease? Acta Obstet. Gynecol. Scandinavica. 2001;80:1036–8.
Soydinc HE, Kan I, Dal T, Evsen MS, Sak ME, Ozler A, et al. Evaluation of the relationship between preeclampsia and seropositivity of infectious disease in maternal plasma. Clin Ter. 2013;164(3):e199-202. doi: 10.7417/CT.2013.1568.
Freeman DJ, McManus F, Brown EA, Cherry L, Norrie J, Ramsay JE, et al. Short- and long-term changes in plasma inflammatory markers associated with preeclampsia. Hypertens (Dallas, Tex 1979). 2004;44:708–14. CrossRef
- Rubella, herpes simplex virus type 2 and preeclampsia
Shimos A. Alshareef
Ahmed M. Eltom
Abubakr M. Nasr
Hamdan Z. Hamdan
- BioMed Central
Neu im Fachgebiet Innere Medizin
Meistgelesene Bücher aus der Inneren Medizin
Sommerakademie-Visual, Mail Icon II