Skip to main content
Erschienen in: Techniques in Coloproctology 6/2019

30.05.2019 | Original Article

Sacral nerve stimulation for constipation: long-term outcomes

verfasst von: S. Gortazar de las Casas, I. Rubio-Pérez, J. Saavedra Ambrosy, A. Sancho de Avila, M. Álvarez-Gallego, J. L. Marijuan Martín, I. Pascual Miguelañez

Erschienen in: Techniques in Coloproctology | Ausgabe 6/2019

Einloggen, um Zugang zu erhalten

Abstract

Background

There has been some controversy regarding the efficacy of sacral nerve stimulation (SNS) for the treatment of chronic constipation, due to less positive outcomes and concerns about cost-effectiveness in the long term. The aim of the present study was to evaluate the long-term outcomes of SNS in patients with chronic constipation.

Methods

A retrospective study was conducted on patients who had SNS for chronic constipation in 2008–2017 at our institution. Clinical factors, profile of constipation, physiology studies, and patient satisfaction with SNS therapy were investigated during a follow-up period up to 10 years after the implantation.

Results

Twenty-nine patients [86% female, median age 49 years (range 17–86)] were tested for SNS, and 24 received implants after a positive test phase [median 47 days (range 21–56 days)]. There were 27 bilateral and 2 unilateral implants, in S3 or S4 depending on best response. Mean follow-up was 59 months. Efficacy was considered as a score > 5 (on a scale of 1–10) in general symptom improvement. Nine (37.9%) implanted patients had a satisfaction score > 5. In 6 cases (25%), patient satisfaction was higher than 9. Due to the small sample size, there were no statistically significant variables considered as predictors of response.

Conclusions

Our results agree with current studies which describe around a 30% response of SNS for refractory constipation. However, there is a small group of patients highly satisfied with SNS therapy. More studies are needed to better understand this profile and optimize outcomes.
Literatur
1.
Zurück zum Zitat Serra J et al (2017) Guía de práctica clínica sobre el manejo del estreñimiento crónico en el paciente adulto: Parte 2: diagnóstico y tratamiento. Gastroenterol. Hepatol. 40:303–316CrossRefPubMed Serra J et al (2017) Guía de práctica clínica sobre el manejo del estreñimiento crónico en el paciente adulto: Parte 2: diagnóstico y tratamiento. Gastroenterol. Hepatol. 40:303–316CrossRefPubMed
2.
Zurück zum Zitat Knowles CH (2017) Constipation. In: Herold A, Lehur PA, Matzel KE, O’Connell PR (eds) Coloproctology, 2nd edn. Springer, Germany, pp 103–120CrossRef Knowles CH (2017) Constipation. In: Herold A, Lehur PA, Matzel KE, O’Connell PR (eds) Coloproctology, 2nd edn. Springer, Germany, pp 103–120CrossRef
4.
Zurück zum Zitat Carrington EV et al (2014) A systematic review of sacral nerve stimulation mechanisms in the treatment of fecal incontinence and constipation. Neurogastroenterol Motil 26:1222–1237CrossRefPubMed Carrington EV et al (2014) A systematic review of sacral nerve stimulation mechanisms in the treatment of fecal incontinence and constipation. Neurogastroenterol Motil 26:1222–1237CrossRefPubMed
5.
Zurück zum Zitat Dinning PG et al (2015) Treatment efficacy of sacral nerve stimulation in slow transit constipation: a two-phase, double-blind randomized controlled crossover study. Am J Gastroenterol 110:733–740CrossRefPubMed Dinning PG et al (2015) Treatment efficacy of sacral nerve stimulation in slow transit constipation: a two-phase, double-blind randomized controlled crossover study. Am J Gastroenterol 110:733–740CrossRefPubMed
6.
Zurück zum Zitat Serra J et al (2017) Guía de práctica clínica sobre el manejo del estreñimiento crónico en el paciente adulto: parte 1: definición, etiología y manifestaciones clínicas. Gastroenterol Hepatol 40:132–141CrossRefPubMed Serra J et al (2017) Guía de práctica clínica sobre el manejo del estreñimiento crónico en el paciente adulto: parte 1: definición, etiología y manifestaciones clínicas. Gastroenterol Hepatol 40:132–141CrossRefPubMed
7.
Zurück zum Zitat Marquis P, De La Loge C, Dubois D, McDermott A, Chassany O (2005) Development and validation of the patient assessment of constipation quality of life questionnaire. Scand J Gastroenterol 40:540–551CrossRefPubMed Marquis P, De La Loge C, Dubois D, McDermott A, Chassany O (2005) Development and validation of the patient assessment of constipation quality of life questionnaire. Scand J Gastroenterol 40:540–551CrossRefPubMed
8.
Zurück zum Zitat Belsey J, Greenfield S, Candy D, Geraint M (2010) Systematic review: Impact of constipation on quality of life in adults and children. Aliment Pharmacol Ther 31:938–949PubMed Belsey J, Greenfield S, Candy D, Geraint M (2010) Systematic review: Impact of constipation on quality of life in adults and children. Aliment Pharmacol Ther 31:938–949PubMed
9.
Zurück zum Zitat SCM H et al. (2017) Sacral neuromodulation versus personalized conservative treatment in patients with idiopathic slow-transit constipation: study protocol of the No. 2-trial, a multicentre randomized controlled trial. Color. Disease Conference 12th Scientific Annual Meeting European Society of Coloproctology Gastroenterology, pp 493–501. doi: 10.1111/codi.13799 SCM H et al. (2017) Sacral neuromodulation versus personalized conservative treatment in patients with idiopathic slow-transit constipation: study protocol of the No. 2-trial, a multicentre randomized controlled trial. Color. Disease Conference 12th Scientific Annual Meeting European Society of Coloproctology Gastroenterology, pp 493–501. doi: 10.1111/codi.13799
10.
Zurück zum Zitat Schiano-di-Visconte M et al (2018) Effectiveness of sacral nerve stimulation in fecal incontinence after multimodal oncologic treatment for pelvic malignancies: a multicenter study with 2-year follow-up. Tech Coloproctol 22:97–105CrossRefPubMed Schiano-di-Visconte M et al (2018) Effectiveness of sacral nerve stimulation in fecal incontinence after multimodal oncologic treatment for pelvic malignancies: a multicenter study with 2-year follow-up. Tech Coloproctol 22:97–105CrossRefPubMed
11.
Zurück zum Zitat Thomas GP, Dudding TC, Rahbour G, Nicholls RJ, Vaizey CJ (2013) Sacral nerve stimulation for constipation. Br J Surg 100:174–181CrossRefPubMed Thomas GP, Dudding TC, Rahbour G, Nicholls RJ, Vaizey CJ (2013) Sacral nerve stimulation for constipation. Br J Surg 100:174–181CrossRefPubMed
12.
Zurück zum Zitat Zeiton M, Faily S, Nicholson J, Telford K, Sharma A (2016) Sacral nerve stimulation—hidden costs (uncovered). Int J Colorectal Dis 31:1005–1010CrossRefPubMed Zeiton M, Faily S, Nicholson J, Telford K, Sharma A (2016) Sacral nerve stimulation—hidden costs (uncovered). Int J Colorectal Dis 31:1005–1010CrossRefPubMed
14.
15.
Zurück zum Zitat Yang D, He L, Su T-R, Chen Y, Wang Q (2018) Outcomes of laparoscopic subtotal colectomy with cecorectal anastomosis for slow-transit constipation: a single center retrospective study. Acta Chir Belg 119:1–5 Yang D, He L, Su T-R, Chen Y, Wang Q (2018) Outcomes of laparoscopic subtotal colectomy with cecorectal anastomosis for slow-transit constipation: a single center retrospective study. Acta Chir Belg 119:1–5
16.
Zurück zum Zitat Lumi CM et al (2016) Neuromodulación sacra: resultados a largo plazo. Acta Gastroenterol Latinoam 46:82–94PubMed Lumi CM et al (2016) Neuromodulación sacra: resultados a largo plazo. Acta Gastroenterol Latinoam 46:82–94PubMed
17.
Zurück zum Zitat Pilkington SA et al (2017) Surgery for constipation: systematic review and practice recommendations: Results V: sacral Nerve stimulation. Color Dis 19:92–100CrossRef Pilkington SA et al (2017) Surgery for constipation: systematic review and practice recommendations: Results V: sacral Nerve stimulation. Color Dis 19:92–100CrossRef
18.
Zurück zum Zitat Xin HW et al (2014) Diagnosis of functional constipation: agreement between Rome III and Rome II criteria and evaluation for the practicality. J Dig Dis 15:314–320CrossRefPubMedPubMedCentral Xin HW et al (2014) Diagnosis of functional constipation: agreement between Rome III and Rome II criteria and evaluation for the practicality. J Dig Dis 15:314–320CrossRefPubMedPubMedCentral
19.
Zurück zum Zitat Ley Orgánica 2/2006, de 3 de mayo, de Educación. BOE 22-06-2007, núm. 149, pág. 27049. Ley Orgánica 2/2006, de 3 de mayo, de Educación. BOE 22-06-2007, núm. 149, pág. 27049.
20.
Zurück zum Zitat Zerbib F et al (2017) Randomized clinical trial of sacral nerve stimulation for refractory constipation. Br J Surg 104:205–213CrossRefPubMed Zerbib F et al (2017) Randomized clinical trial of sacral nerve stimulation for refractory constipation. Br J Surg 104:205–213CrossRefPubMed
21.
Zurück zum Zitat Patton V, Stewart P, Lubowski DZ, Cook IJ, Dinning PG (2016) Sacral nerve stimulation fails to offer long-term benefit in patients with slow-transit constipation. Dis Colon Rectum 59:878–885CrossRefPubMed Patton V, Stewart P, Lubowski DZ, Cook IJ, Dinning PG (2016) Sacral nerve stimulation fails to offer long-term benefit in patients with slow-transit constipation. Dis Colon Rectum 59:878–885CrossRefPubMed
22.
Zurück zum Zitat Knowles CH, Thin N, Gill K, Bhan C (2012) Prospective randomized double-blind study of temporary sacral nerve stimulation in patients with rectal evacuatory dysfunction and rectal hyposensitivity. Ann Surg 255(4):643–649CrossRefPubMed Knowles CH, Thin N, Gill K, Bhan C (2012) Prospective randomized double-blind study of temporary sacral nerve stimulation in patients with rectal evacuatory dysfunction and rectal hyposensitivity. Ann Surg 255(4):643–649CrossRefPubMed
23.
24.
Zurück zum Zitat Carriero A, Martelluci J, Talenento P, Ferrari CA (2010) Sacral nerve stimulation for constipation: do we still miss something? Int J Colorectal Dis 25:1005–1010CrossRefPubMed Carriero A, Martelluci J, Talenento P, Ferrari CA (2010) Sacral nerve stimulation for constipation: do we still miss something? Int J Colorectal Dis 25:1005–1010CrossRefPubMed
25.
Zurück zum Zitat Maeda Y, Matzel K, Lundby L, Buntzen S, Laurberg S (2011) Postoperative issues of sacral nerve stimulation for fecal incontinence and constipation: a systematic literature review and treatment guideline. Dis Colon Rectum 54:1443–1460CrossRefPubMed Maeda Y, Matzel K, Lundby L, Buntzen S, Laurberg S (2011) Postoperative issues of sacral nerve stimulation for fecal incontinence and constipation: a systematic literature review and treatment guideline. Dis Colon Rectum 54:1443–1460CrossRefPubMed
26.
Zurück zum Zitat Maeda Y et al (2015) Sacral nerve stimulation for faecal incontinence and constipation: a European consensus statement. Color Dis 17:O74–O87CrossRef Maeda Y et al (2015) Sacral nerve stimulation for faecal incontinence and constipation: a European consensus statement. Color Dis 17:O74–O87CrossRef
Metadaten
Titel
Sacral nerve stimulation for constipation: long-term outcomes
verfasst von
S. Gortazar de las Casas
I. Rubio-Pérez
J. Saavedra Ambrosy
A. Sancho de Avila
M. Álvarez-Gallego
J. L. Marijuan Martín
I. Pascual Miguelañez
Publikationsdatum
30.05.2019
Verlag
Springer International Publishing
Erschienen in
Techniques in Coloproctology / Ausgabe 6/2019
Print ISSN: 1123-6337
Elektronische ISSN: 1128-045X
DOI
https://doi.org/10.1007/s10151-019-02011-z

Weitere Artikel der Ausgabe 6/2019

Techniques in Coloproctology 6/2019 Zur Ausgabe

Update Chirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

S3-Leitlinie „Diagnostik und Therapie des Karpaltunnelsyndroms“

Karpaltunnelsyndrom BDC Leitlinien Webinare
CME: 2 Punkte

Das Karpaltunnelsyndrom ist die häufigste Kompressionsneuropathie peripherer Nerven. Obwohl die Anamnese mit dem nächtlichen Einschlafen der Hand (Brachialgia parästhetica nocturna) sehr typisch ist, ist eine klinisch-neurologische Untersuchung und Elektroneurografie in manchen Fällen auch eine Neurosonografie erforderlich. Im Anfangsstadium sind konservative Maßnahmen (Handgelenksschiene, Ergotherapie) empfehlenswert. Bei nicht Ansprechen der konservativen Therapie oder Auftreten von neurologischen Ausfällen ist eine Dekompression des N. medianus am Karpaltunnel indiziert.

Prof. Dr. med. Gregor Antoniadis
Berufsverband der Deutschen Chirurgie e.V.

S2e-Leitlinie „Distale Radiusfraktur“

Radiusfraktur BDC Leitlinien Webinare
CME: 2 Punkte

Das Webinar beschäftigt sich mit Fragen und Antworten zu Diagnostik und Klassifikation sowie Möglichkeiten des Ausschlusses von Zusatzverletzungen. Die Referenten erläutern, welche Frakturen konservativ behandelt werden können und wie. Das Webinar beantwortet die Frage nach aktuellen operativen Therapiekonzepten: Welcher Zugang, welches Osteosynthesematerial? Auf was muss bei der Nachbehandlung der distalen Radiusfraktur geachtet werden?

PD Dr. med. Oliver Pieske
Dr. med. Benjamin Meyknecht
Berufsverband der Deutschen Chirurgie e.V.

S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“

Appendizitis BDC Leitlinien Webinare
CME: 2 Punkte

Inhalte des Webinars zur S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“ sind die Darstellung des Projektes und des Erstellungswegs zur S1-Leitlinie, die Erläuterung der klinischen Relevanz der Klassifikation EAES 2015, die wissenschaftliche Begründung der wichtigsten Empfehlungen und die Darstellung stadiengerechter Therapieoptionen.

Dr. med. Mihailo Andric
Berufsverband der Deutschen Chirurgie e.V.