Erschienen in:
01.03.2005 | Correspondence
Safety of endotoxin challenge in healthy volunteers: bradycardia
verfasst von:
Bernd Jilma
Erschienen in:
Intensive Care Medicine
|
Ausgabe 3/2005
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Excerpt
Sir: human endotoxemia is a well-standardized and safe model to study systemic inflammation or coagulation [
1,
2] and the pharmacodynamic effects of novel therapeutic agents during early phase drug development [
3]. Recently, van Eijk et al. have reported the occurrence of severe bradycardia or protracted asystole after infusion of endotoxin [
4]. They had observed two cases during their study. In addition, two further cases were identified after review of the published literature [
5] and interviews by three established investigators, who challenged approximately 2,200 subjects with Reference Endotoxin
E. coli: 0113 in the last 25 years [
4]. …