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26.04.2019 | Original Paper

Salacia chinensis stem extract and its thiosugar sulfonium constituent, neokotalanol, improves HbA1c levels in ob/ob mice

verfasst von: Masakazu Kobayashi, Junji Akaki, Yasuyo Yamaguchi, Hiroo Yamasaki, Kiyofumi Ninomiya, Yutana Pongpiriyadacha, Masayuki Yoshikawa, Osamu Muraoka, Toshio Morikawa

Erschienen in: Journal of Natural Medicines | Ausgabe 3/2019

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Abstract

The antidiabetic effects of a hot water extract of the stems of Salacia chinensis (SCE) were evaluated in vivo in ob/ob mice (genetically obese hyperglycemic mice). Administration of dietary feed containing 0.20 and 0.50% of SCE for 23 days to ob/ob mice significantly suppressed the elevation of both blood glucose and HbA1c levels, without significantly changing body weight and food intake. To characterize the antidiabetic effects of the thiosugar sulfonium constituent neokotalanol (1), which has potent α-glucosidase inhibitory activity, we performed a similar in vivo study. HbA1c levels were significantly suppressed in ob/ob mice after the administration of dietary feed containing 0.0003% of neokotalanol (1) for 20 days. These results indicate that SCE and neokotalanol (1) are potential leads for the development of novel antidiabetic agents.

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Lindström P (2007) The physiology of obese-hyperglycemic mice [ob/ob mice]. Sci World J 7:666–685CrossRef

Wang B, Chandrasekera PC, Pippin JJ (2014) Leptin- and leptin receptor-deficient rodent models: relevance for human type 2 diabetes. Curr Diab Rev 10:131–145CrossRef

Betz B, Conway BR (2016) An update on the use of animal models in diabetic nephropathy research. Curr Diab Rep 16:18CrossRef

Mayer J, Russel E, Bates MV, Dickie MM (1953) Metabolic, nutritional and endocrine studies of the hereditary obesity-diabetes syndrome of mice and mechanism of its development. Metabolism 2:9–21PubMed

Garthwaite TL, Martinson DR, Tseng LF, Hagen TC, Menahan LA (1980) A longitudinal hormonal profile of the genetically obese mice. Endocrinology 107:671–676CrossRef

Xie J-T, Mehendale SR, Li X, Quigg R, Wang X, Wang C-Z, Wu JA, Aung HH, Rue PA, Bell GI, Yuan C-S (2005) Anti-diabetic effect of ginsenoside Re in ob/ob mice. Biochim Biophys Acta 1740:319–325CrossRef

Lee Y-S, Cha B-Y, Saito K, Yamakawa H, Choi S-S, Yamaguchi K, Yonezawa T, Teruya T, Nagai K, Woo J-T (2010) Nobiletin improves hyperglycemia and insulin resistance in obese diabetic ob/ob mice. Biochem Pharmcol 79:1674–1683CrossRef

Huang S-L, Yu R-T, Gong J, Feng Y, Dai Y-L, Hu F, Hu Y-H, Tao Y-D, Leng Y (2012) Arctigenin, a natural compound, activates AMP-activated protein kinase via inhibition of mitochondria complex I and ameliorates metabolic disorders in ob/ob mice. Diabetologia 55:1469–1481CrossRef

Matsuda H, Yoshikawa M, Morikawa T, Tanabe G, Muraoka O (2005) Antidiabetogenic constituents from Salacia species. J Tradit Med 22(Suppl 1):145–153

10.

Yoshikawa M, Morikawa T, Matsuda H, Tanabe G, Muraoka O (2002) Absolute stereostructure of potent α-glucosidase inhibitor, salacinol, with unique thiosugar sulfonium sulfate inner salt structure from Salacia reticulata. Bioorg Med Chem 10:1547–1554CrossRef

11.

Yoshikawa M, Pongpiriyadacha Y, Kishi A, Kageura T, Wang T, Morikawa T, Matsuda H (2003) Biological activities of Salacia chinensis originating in Thailand: the quality evaluation guided by α-glucosidase inhibitory activity. Yakugaku Zasshi 123:871–880CrossRef

12.

Morikawa T, Akaki J, Ninomiya K, Kinouchi E, Tanabe G, Pongpiriyadacha Y, Yoshikawa M, Muraoka O (2015) Salacinol and related analogs: new leads for type 2 diabetes therapeutic candidates from the Thai traditional natural medicine Salacia chinensis. Nutrients 7:1480–1493CrossRef

13.

Muraoka O, Morikawa T, Miyake S, Akaki J, Ninomiya K, Pongpiriyadacha Y, Yoshikawa M (2011) Quantitative analysis of neosalacinol and neokotalanol, another two potent α-glucosidase inhibitors from Salacia species, by LC–MS with ion pair chromatography. J Nat Med 65:142–148CrossRef

14.

Muraoka O, Xie W, Osaki S, Kagawa A, Tanabe G, Amer MFA, Minematsu T, Morikawa T, Yoshikawa M (2010) Characteristic alkaline catalyzed degradation of kotalanol, a potent α-glucosidase inhibitor isolated from Ayurvedic traditional medicine Salacia reticulata, leading to anhydroheptitols: another structural proof. Tetrahedron 66:3717–3722CrossRef

15.

Muraoka O, Morikawa T, Miyake S, Akaki J, Ninomiya K, Yoshikawa M (2010) Quantitative determination of potent α-glucosidase inhibitors, salacinol and kotalanol, in Salacia species using liquid chromatography-mass spectrometry. J Pharm Biomed Anal 52:770–773CrossRef

16.

Xie W, Tanabe G, Akaki J, Morikawa T, Ninomiya K, Minematsu T, Yoshikawa M, Wu X, Muraoka O (2011) Isolation, structure identification and SAR studies on thiosugar sulfonium salts, neosalaprinol and neoponkoranol, as potent α-glucosidase inhibitors. Bioorg Med Chem 19:2015–2022CrossRef

17.

Xie W, Tanabe G, Xu J, Wu X, Morikawa T, Yoshikawa M, Muraoka O (2013) Research progress of synthesis and structure-activity relationship studies on sulfonium-type α-glucosidase inhibitors isolated from Salacia genus plants. Mini Rev Org Chem 10:141–159CrossRef

18.

Akaki J, Morikawa T, Miyake S, Ninomiya K, Okada M, Tanabe G, Pongpiriyadacha Y, Yoshikawa M, Muraoka O (2014) Evaluation of Salacia species as anti-diabetic natural resources based on quantitative analysis of eight sulphonium constituents: a new class of α-glucosidase inhibitors. Phytochem Anal 25:544–550CrossRef

19.

Kobayashi M, Akaki J, Yamashita K, Morikawa T, Ninomiya K, Yoshikawa M, Muraoka O (2010) Suippressive effect of the tablet containing Salacia chinensis extract on postprandial blood glucose. Jpn Pharmacol Ther 38:545–550

20.

Kobayashi M, Akaki J, Yamaguchi Y, Yamasaki H, Morikawa T, Ninomiya K, Yoshikawa M, Muraoka O (2016) Safety evaluation of long term and excess intake of the tablet containing hot water extract of Salacia hinensis. Jpn Pharmacol Ther 44:399–408

21.

Yamada K, Sato-Mito N, Nagata J, Umegak K (2008) Health claim evidence requirements in Japan. J Nutr 138:1192S–1198SCrossRef

22.

Tsutani K, Takuma H (2008) Regulatory sciences in herbal medicines and dietary supplements. Yakugaku Zasshi 128:867–880CrossRef

23.

Nagata J, Yamada K (2008) Foods with health claims in Japan. Food Sci Technol Res 14:519–524CrossRef

24.

Shimizu M (2012) Functional food in Japan: current status and future of gut-modulating food. J Food Drug Anal 20(Suppl 1):213–216

25.

Kashiwagi A, Kasuga M, Araki E, Oka Y, Hanafusa T, Ito H, Tominaga M, Oikawa S, Noda M, Kawamura T, Sanke T, Namba M, Hashiramoto M, Sasahara T, Nishio Y, Kuwa K, Ueki K, Takei I, Umemoto M, Murakami M, Yamakado M, Yatomi Y, Ohashi H (2012) Committee on the standardization of diebetes mellitus-related laboratory testing of Japan Diabetes Society. International clinical harmonization of glycated hemoglobin in Japan: from Japan diabetes society to national glycohemoglobin standardization program values. J Diabetes Investig 3:39–40CrossRef

Titel: Salacia chinensis stem extract and its thiosugar sulfonium constituent, neokotalanol, improves HbA1c levels in ob/ob mice
verfasst von: Masakazu Kobayashi
Junji Akaki
Yasuyo Yamaguchi
Hiroo Yamasaki
Kiyofumi Ninomiya
Yutana Pongpiriyadacha
Masayuki Yoshikawa
Osamu Muraoka
Toshio Morikawa
Publikationsdatum: 26.04.2019
Verlag: Springer Singapore
Erschienen in: Journal of Natural Medicines / Ausgabe 3/2019
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-019-01311-w

Springer Medizin

Abstract

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