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18.09.2021 | Original Article

Saliva secretion is reduced in mild reflux esophagitis patients

verfasst von: Mai Koeda, Tomohide Tanabe, Yuichi Kitasako, Eri Momma, Yoshimasa Hoshikawa, Shintaro Hoshino, Noriyuki Kawami, Mitsuru Kaise, Katsuhiko Iwakiri

Erschienen in: Esophagus | Ausgabe 2/2022

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Abstract

Background

Salivary secretion in patients with mild reflux esophagitis has not been examined. In this study, saliva secretion and salivary epidermal growth factor (EGF) in patients with mild reflux esophagitis were investigated.

Methods

Thirty-eight mild reflux esophagitis patients and 38 control subjects were recruited for this case–control study. Saliva secretion testing was performed. Saliva secretion was assessed as follows: each patient chewed sugar-free gum for 3 min prior to endoscopy, and the volume and pH of saliva before and after acid loading as an index of the acid-buffering capacity were measured. The salivary EGF concentration was assessed by ELISA.

Results

The volume of saliva secreted was significantly (p = 0.0412) lower in the mild reflux esophagitis group than in the control group, with medians (25th–75th percentile) of 4.2 mL/3 min [2.6–6.2] and 6.0 [3.9–8.0], respectively. No significant differences were observed in salivary pH (the mild reflux esophagitis group: 7.1 [6.9–7.2], the control group 7.2 [7.1–7.3]). Salivary pH after acid loading was significantly (p = 0.0009) lower in the mild reflux esophagitis group (5.9 [5.5–6.3]) than in the control group (6.3 [6.2–6.5]). No significant differences were noted in salivary EGF concentrations (the mild reflux esophagitis group: 1739.0 pg/mL [1142.3–3329.0], the control group: 1678.0 [1091.8–2122.5].

Conclusion

The secretion volume and acid-buffering capacity of stimulated saliva were reduced in patients with mild reflux esophagitis.
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Metadaten
Titel
Saliva secretion is reduced in mild reflux esophagitis patients
verfasst von
Mai Koeda
Tomohide Tanabe
Yuichi Kitasako
Eri Momma
Yoshimasa Hoshikawa
Shintaro Hoshino
Noriyuki Kawami
Mitsuru Kaise
Katsuhiko Iwakiri
Publikationsdatum
18.09.2021
Verlag
Springer Singapore
Erschienen in
Esophagus / Ausgabe 2/2022
Print ISSN: 1612-9059
Elektronische ISSN: 1612-9067
DOI
https://doi.org/10.1007/s10388-021-00880-8

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