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04.09.2015 | Original Article | Ausgabe 2/2016

International Journal of Clinical Oncology 2/2016

Sarcopenia, but not visceral fat amount, is a risk factor of postoperative complications after major hepatectomy

Zeitschrift:
International Journal of Clinical Oncology > Ausgabe 2/2016
Autoren:
Takaaki Higashi, Hiromitsu Hayashi, Katsunobu Taki, Keita Sakamoto, Hideyuki Kuroki, Hidetoshi Nitta, Daisuke Hashimoto, Akira Chikamoto, Toru Beppu, Hideo Baba
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1007/​s10147-015-0898-0) contains supplementary material, which is available to authorized users.
An erratum to this article is available at https://​doi.​org/​10.​1007/​s10147-017-1163-5.

Abstract

Background

Major hepatectomy is associated with significant morbidity and mortality rates, particularly in patients aged more than 70 years. This study assessed whether physical indicators, such as sarcopenia and visceral fat amount, could predict morbidity and mortality after major hepatectomy.

Methods

The study enrolled 144 patients who underwent curative major hepatectomy. Skeletal muscle and visceral fat amount at the third lumbar vertebra (L3) in the inferior direction were quantified using enhanced computed tomography scans. The patients were divided into two subgroups, with and without sarcopenia, based on median skeletal muscle mass in men and women (43.2 cm2/m2 in men; 35.3 cm2/m2 in women).

Results

The study included 108 men and 36 women, with median skeletal muscle tissue of 43.2 and 35.3 cm2/m2, respectively. The mortality rate was significantly higher in patients with than without sarcopenia [seven cases (9.7 %), one case (1.4 %), respectively; P = 0.021], whereas liver-related morbidity and mortality rates were similar. In patients aged >70 years, the morbidity, liver dysfunction-related morbidity, and mortality rates were significantly higher in patients with than without sarcopenia (P < 0.05 each). In contrast, surgical outcomes were similar in patients with high and low visceral fat amounts.

Conclusions

Sarcopenia was a risk factor for postoperative complications after major hepatectomy, particularly in elderly patients.

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Zusatzmaterial
Supplementary material 1 (TIFF 194 kb)
10147_2015_898_MOESM1_ESM.tif
Supplementary material 2 (DOCX 30 kb)
10147_2015_898_MOESM2_ESM.docx
Literatur
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