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05.04.2021 | Ewing-Sarkom | Schwerpunkt: Neue WHO-Klassifikationen und Digitales Lernen

Neues in der aktuellen WHO-Klassifikation (2020) für Weichgewebssarkome

verfasst von: Prof. Dr. Eva Wardelmann, Wolfgang Hartmann

Erschienen in: Die Pathologie | Ausgabe 3/2021

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Zusammenfassung

Die aktuelle WHO-Klassifikation für Weichgewebs- und Knochensarkome aus 2020 beinhaltet zahlreiche neue Entitäten, die zumeist infolge neuer molekularpathologischer Befunde definiert wurden. In der folgenden Arbeit stellen wir vornehmlich translokationspositive Tumoren vor, die das Spektrum monomorphzelliger Neoplasien erweitern. Die undifferenzierten klein-rundzelligen Sarkome haben in der WHO-Klassifikation ein eigenes Kapitel erhalten, um die morphologischen, molekularpathologischen und biologischen Besonderheiten der einzelnen Subtypen zu würdigen. Eine weitere Besonderheit stellen derzeit noch nicht in der WHO-Klassifikation befindliche Tumoren mit GLI1-Aktivierung dar, deren Biologie sich durch ganz unterschiedliche Aktivierungsmechanismen erheblich unterscheiden kann. NTRK-getriebene Tumoren bieten als Besonderheit ein therapeutisches Target an, gegen das verschiedene Inhibitoren zur Verfügung stehen. Schließlich gibt es auch bei den Rhabdomyosarkomen neue, molekular definierte Subtypen mit unterschiedlicher Biologie.

WHO (2020) International agency for research on cancer, 5. Aufl. WHO classification of tumour series, Bd. 3. WHO Classification of Tumours Editorial Board, Soft tissue and bone tumours, Lyon

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53.

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Titel: Neues in der aktuellen WHO-Klassifikation (2020) für Weichgewebssarkome
verfasst von: Prof. Dr. Eva Wardelmann
Wolfgang Hartmann
Publikationsdatum: 05.04.2021
Verlag: Springer Medizin
Schlagwörter: Ewing-Sarkom
Sarkome
Ewing-Sarkom
Rhabdomyosarkome
Erschienen in: Die Pathologie / Ausgabe 3/2021
Print ISSN: 2731-7188
Elektronische ISSN: 2731-7196
DOI: https://doi.org/10.1007/s00292-021-00935-8

Neu im Fachgebiet Onkologie

24.04.2024 | DGIM 2024 | Nachrichten

Springer Medizin

Neues in der aktuellen WHO-Klassifikation (2020) für Weichgewebssarkome

Zusammenfassung

Neu im Fachgebiet Onkologie

Bei Senioren mit Prostatakarzinom auf Anämie achten!

ICI-Therapie in der Schwangerschaft wird gut toleriert

Krebspatienten impfen: Was? Wen? Und wann nicht?

Müde im Alter? Auch an die Nebenniere denken

Update Onkologie

Springer Medizin

Zusammenfassung

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