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Erschienen in: hautnah dermatologie 4/2017

17.07.2017 | Zertifizierte Fortbildung

Dermatologisches Nebenwirkungsmanagement zielgerichteter Onkologika

Schattenseiten der Targeted Therapy

verfasst von: Janina Below, PD Dr. med. Peter Arne Gerber

Erschienen in: hautnah dermatologie | Ausgabe 4/2017

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Zusammenfassung

Zielgerichtete onkologische Therapieregime haben in den letzten Jahren in vielen Indikationen zunehmend an Bedeutung gewonnen. Doch neue Wirkungen kommen meist nicht ohne neue Nebenwirkungen. Oftmals sind diese kutaner Art, wodurch dem Dermatologen eine Schlüsselrolle beim Nebenwirkungsmanagement zukommt.
Literatur
1.
Zurück zum Zitat Hirsch FR et al. New and emerging targeted treatments in advanced non-small-cell lung cancer. Lancet 2016; 388: 1012–24CrossRefPubMed Hirsch FR et al. New and emerging targeted treatments in advanced non-small-cell lung cancer. Lancet 2016; 388: 1012–24CrossRefPubMed
2.
Zurück zum Zitat Matter A. Bridging academic science and clinical research in the search for novel targeted anti-cancer agents. Cancer Biol Med 2015; 12: 316–27PubMedPubMedCentral Matter A. Bridging academic science and clinical research in the search for novel targeted anti-cancer agents. Cancer Biol Med 2015; 12: 316–27PubMedPubMedCentral
3.
Zurück zum Zitat Funakoshi T et al. Infectious complications in cancer patients treated with anti-EGFR monoclonal antibodies cetuximab and panitumumab: a systematic review and meta-analysis. Cancer Treat Rev 2014; 40: 1221–9CrossRefPubMed Funakoshi T et al. Infectious complications in cancer patients treated with anti-EGFR monoclonal antibodies cetuximab and panitumumab: a systematic review and meta-analysis. Cancer Treat Rev 2014; 40: 1221–9CrossRefPubMed
4.
Zurück zum Zitat Gutzmer R et al. Management of cutaneous side effects of EGFR inhibitors: recommendations from a German expert panel for the primary treating physician. J Dermatol Ges 2011; 9: 195–202 Gutzmer R et al. Management of cutaneous side effects of EGFR inhibitors: recommendations from a German expert panel for the primary treating physician. J Dermatol Ges 2011; 9: 195–202
5.
Zurück zum Zitat Wacker B et al. Correlation between development of rash and efficacy in patients treated with the epidermal growth factor receptor tyrosine kinase inhibitor erlotinib in two large phase III studies. Clin Cancer Res 2007; 13: 3913–21CrossRefPubMed Wacker B et al. Correlation between development of rash and efficacy in patients treated with the epidermal growth factor receptor tyrosine kinase inhibitor erlotinib in two large phase III studies. Clin Cancer Res 2007; 13: 3913–21CrossRefPubMed
6.
Zurück zum Zitat Lichtenberger BM et al. Epidermal EGFR controls cutaneus host defense and prevents inflammation. Sci Transl Med 2013; 5: 199ra111CrossRefPubMed Lichtenberger BM et al. Epidermal EGFR controls cutaneus host defense and prevents inflammation. Sci Transl Med 2013; 5: 199ra111CrossRefPubMed
7.
Zurück zum Zitat Gerber PA et al. Density of demodex folliculorum in patients receiving epidermal growth factor receptor inhibitors. Dermatology 2011; 222: 144–7CrossRefPubMed Gerber PA et al. Density of demodex folliculorum in patients receiving epidermal growth factor receptor inhibitors. Dermatology 2011; 222: 144–7CrossRefPubMed
8.
Zurück zum Zitat Gerber PA et al. Preliminary evidence for a role of mast cells in epidermal growth factor receptor inhibitor-induced pruritus. J Am Acad Dermatol 2010; 63: 163–5CrossRefPubMed Gerber PA et al. Preliminary evidence for a role of mast cells in epidermal growth factor receptor inhibitor-induced pruritus. J Am Acad Dermatol 2010; 63: 163–5CrossRefPubMed
9.
Zurück zum Zitat Gerber PA et al. Mechanisms of skin aging induced by EGFR inhibitors. Support Care Cancer 2016; 24: 4241–8CrossRefPubMed Gerber PA et al. Mechanisms of skin aging induced by EGFR inhibitors. Support Care Cancer 2016; 24: 4241–8CrossRefPubMed
10.
Zurück zum Zitat Segaert S et al. Skin toxicities of targeted therapies. Eur J Cancer 2009; 45(Suppl 1): 295–308CrossRefPubMed Segaert S et al. Skin toxicities of targeted therapies. Eur J Cancer 2009; 45(Suppl 1): 295–308CrossRefPubMed
11.
Zurück zum Zitat Gerber PA et al. Images in clinical medicine. Erlotinib-induced hair alterations. N Engl J Med 2008; 358: 1175CrossRefPubMed Gerber PA et al. Images in clinical medicine. Erlotinib-induced hair alterations. N Engl J Med 2008; 358: 1175CrossRefPubMed
12.
Zurück zum Zitat Lacouture ME et al. Clinical practice guidelines for the prevention and treatment of EGFR-inhibitor- associated dermatologic toxicities. Support Care Cancer 2011; 19: 1079–95CrossRefPubMedPubMedCentral Lacouture ME et al. Clinical practice guidelines for the prevention and treatment of EGFR-inhibitor- associated dermatologic toxicities. Support Care Cancer 2011; 19: 1079–95CrossRefPubMedPubMedCentral
13.
Zurück zum Zitat Bölke E et al. Development and management of severe cutaneous side effects in head-and-neck cancer patients during concurrent radiotherapy and cetuximab. Strahlenther Onkol 2008; 184: 105–10CrossRefPubMed Bölke E et al. Development and management of severe cutaneous side effects in head-and-neck cancer patients during concurrent radiotherapy and cetuximab. Strahlenther Onkol 2008; 184: 105–10CrossRefPubMed
14.
Zurück zum Zitat Budach W et al. Severe cutaneous reaction during radiation therapy with concurrent cetuximab. N Eng J Med 2007; 357: 514–5CrossRef Budach W et al. Severe cutaneous reaction during radiation therapy with concurrent cetuximab. N Eng J Med 2007; 357: 514–5CrossRef
15.
Zurück zum Zitat Gerber PA et al. Radiation induced prevention of erlotinib-induced skin rash is transient: a new aspect toward the understanding of epidermal growth factor receptor inhibitor associated cutaneous adverse effects. J Clin Oncol 2007; 25: 4697–98 (author reply 4698–4699)CrossRefPubMed Gerber PA et al. Radiation induced prevention of erlotinib-induced skin rash is transient: a new aspect toward the understanding of epidermal growth factor receptor inhibitor associated cutaneous adverse effects. J Clin Oncol 2007; 25: 4697–98 (author reply 4698–4699)CrossRefPubMed
16.
Zurück zum Zitat Lacouture ME et al. Skin toxicity evaluation protocol with panitumumab (STEPP), a phase II, open-label, randomized trial evaluating the impact of a pre-emptive skin treatment regimen on skin toxicities and quality of life in patients with metastatic colorectal cancer. J Clin Oncol 2010; 28: 1351–7CrossRefPubMed Lacouture ME et al. Skin toxicity evaluation protocol with panitumumab (STEPP), a phase II, open-label, randomized trial evaluating the impact of a pre-emptive skin treatment regimen on skin toxicities and quality of life in patients with metastatic colorectal cancer. J Clin Oncol 2010; 28: 1351–7CrossRefPubMed
17.
Zurück zum Zitat Vaubel J et al. Retarded low-dose doxycycline for EGFR or MEK inhibitor-induced papulopustular rash. J Eur Acad Dermatol Venerol 2014; 28: 1685–9CrossRef Vaubel J et al. Retarded low-dose doxycycline for EGFR or MEK inhibitor-induced papulopustular rash. J Eur Acad Dermatol Venerol 2014; 28: 1685–9CrossRef
18.
Zurück zum Zitat Gerber PA et al. Management of EGFR-inhibitor associated rash: a retrospective study in 49 patients. Eur J Med Res 2012; 23: 4CrossRef Gerber PA et al. Management of EGFR-inhibitor associated rash: a retrospective study in 49 patients. Eur J Med Res 2012; 23: 4CrossRef
20.
Zurück zum Zitat Gerber PA et al. The Koebner-phenomenon in epidermal growth factor receptor inhibitor associated cutaneous adverse effects. J Clin Oncol 2008; 26: 2790–2CrossRefPubMed Gerber PA et al. The Koebner-phenomenon in epidermal growth factor receptor inhibitor associated cutaneous adverse effects. J Clin Oncol 2008; 26: 2790–2CrossRefPubMed
21.
Zurück zum Zitat Jo JC et al. Topical vitamin K1 may not be effective in preventing acneiform rash during cetuximab treatment in patients with metastatic colorectal cancer. Eur J Dermatol 2013; 23: 77–82PubMed Jo JC et al. Topical vitamin K1 may not be effective in preventing acneiform rash during cetuximab treatment in patients with metastatic colorectal cancer. Eur J Dermatol 2013; 23: 77–82PubMed
22.
Zurück zum Zitat Ocvirk J et al. A review of the treatment options for skin rash induced by EGFR-targeted therapies: evidence from randomized clinical trials and a meta-analysis. Radiol Oncol 2013; 47: 166–75CrossRefPubMedPubMedCentral Ocvirk J et al. A review of the treatment options for skin rash induced by EGFR-targeted therapies: evidence from randomized clinical trials and a meta-analysis. Radiol Oncol 2013; 47: 166–75CrossRefPubMedPubMedCentral
23.
Zurück zum Zitat Gerber PA et al. More on aprepitant for erlotinib-induced pruritus. N Engl J Med 2011; 364: 486–7CrossRefPubMed Gerber PA et al. More on aprepitant for erlotinib-induced pruritus. N Engl J Med 2011; 364: 486–7CrossRefPubMed
24.
Zurück zum Zitat Santini D et al. Aprepitant for management of severe pruritus related to biological cancer treatments: a pilot study. Lancet Oncol 2012; 13: 1020–4CrossRefPubMed Santini D et al. Aprepitant for management of severe pruritus related to biological cancer treatments: a pilot study. Lancet Oncol 2012; 13: 1020–4CrossRefPubMed
25.
Zurück zum Zitat Lupu I et al. Cutaneous complications of molecular targeted therapy used in oncology. J Med Life 2016; 9: 19–25PubMedPubMedCentral Lupu I et al. Cutaneous complications of molecular targeted therapy used in oncology. J Med Life 2016; 9: 19–25PubMedPubMedCentral
26.
Zurück zum Zitat Rosenbaum SE et al. Dermatological reactions to the multitargeted tyrosine kinase inhibitor sunitinib. Support Care Cancer 2008; 16: 557–66CrossRefPubMed Rosenbaum SE et al. Dermatological reactions to the multitargeted tyrosine kinase inhibitor sunitinib. Support Care Cancer 2008; 16: 557–66CrossRefPubMed
29.
Zurück zum Zitat Degen A et al. The hand- foot-syndrome associated with medical tumor therapy — classification and management. J Dtsch Dermatol Ges 2010; 8: 652–61PubMed Degen A et al. The hand- foot-syndrome associated with medical tumor therapy — classification and management. J Dtsch Dermatol Ges 2010; 8: 652–61PubMed
30.
Zurück zum Zitat Miller KK et al. Chemotherapy-induced hand-foot syndrome and nail changes: a review of clinical presentation, etiology, pathogenesis, and management. J Am Acad Dermatol 2014; 71: 787–94CrossRefPubMed Miller KK et al. Chemotherapy-induced hand-foot syndrome and nail changes: a review of clinical presentation, etiology, pathogenesis, and management. J Am Acad Dermatol 2014; 71: 787–94CrossRefPubMed
31.
Zurück zum Zitat Vincenzi B et al. Early skin toxicity as a predictive factor for tumor control in hepatocellular carcinoma patients treated with sorafenib. Oncologist 2010; 15: 85–92CrossRefPubMedPubMedCentral Vincenzi B et al. Early skin toxicity as a predictive factor for tumor control in hepatocellular carcinoma patients treated with sorafenib. Oncologist 2010; 15: 85–92CrossRefPubMedPubMedCentral
32.
Zurück zum Zitat Hofheinz RD et al. Mapisal versus urea cream as prophylaxis for capecitabine- associated hand-foot syndrome: a randomized phase III trial of the AIO quality of life working group. J Clin Oncol 2015; 33: 2444–8CrossRefPubMed Hofheinz RD et al. Mapisal versus urea cream as prophylaxis for capecitabine- associated hand-foot syndrome: a randomized phase III trial of the AIO quality of life working group. J Clin Oncol 2015; 33: 2444–8CrossRefPubMed
33.
Zurück zum Zitat Scotte F et al. Multicenter study of a frozen glove to prevent docetaxel- induced onycholysis and cutaneous toxicity of the hand. J Clin Oncol 2005; 23: 4424–9CrossRefPubMed Scotte F et al. Multicenter study of a frozen glove to prevent docetaxel- induced onycholysis and cutaneous toxicity of the hand. J Clin Oncol 2005; 23: 4424–9CrossRefPubMed
34.
Zurück zum Zitat Curtin JA et al. Distinct sets of genetic alterations in melanoma. N Eng J Med 2005; 353: 2135–47CrossRef Curtin JA et al. Distinct sets of genetic alterations in melanoma. N Eng J Med 2005; 353: 2135–47CrossRef
35.
Zurück zum Zitat Robert C J et al. Improved overall survival in Melanoma with combined dabrafenib and trametinib. N Eng J Med 2015; 372: 30–9CrossRef Robert C J et al. Improved overall survival in Melanoma with combined dabrafenib and trametinib. N Eng J Med 2015; 372: 30–9CrossRef
36.
Zurück zum Zitat Zimmer L et al. Incidence of new primary melanoma after diagnosis of stage III and IV melanoma. J Clin Oncol 2014; 32: 816–23CrossRefPubMed Zimmer L et al. Incidence of new primary melanoma after diagnosis of stage III and IV melanoma. J Clin Oncol 2014; 32: 816–23CrossRefPubMed
37.
Zurück zum Zitat Zimmer L et al. Side effects of systemic oncological therapies in dermatology. J Dtsch Dermatol Ges 2012; 10: 475–86PubMed Zimmer L et al. Side effects of systemic oncological therapies in dermatology. J Dtsch Dermatol Ges 2012; 10: 475–86PubMed
39.
Zurück zum Zitat Boussemart L et al. Prospective study of cutaneous side-effects associated with the BRAF inhibitor vemurafenib: a study of 42 patients. Ann Oncol 2013; 24: 1691–7CrossRefPubMed Boussemart L et al. Prospective study of cutaneous side-effects associated with the BRAF inhibitor vemurafenib: a study of 42 patients. Ann Oncol 2013; 24: 1691–7CrossRefPubMed
40.
Zurück zum Zitat Dummer R et al. Ultraviolet a and photosensitivity during vemurafenib therapy. N Engl J Med 2012; 366: 480–1CrossRefPubMed Dummer R et al. Ultraviolet a and photosensitivity during vemurafenib therapy. N Engl J Med 2012; 366: 480–1CrossRefPubMed
41.
Zurück zum Zitat Satzger I et al. Serious skin toxicity with the combination of BRAF-inhibitors and radiotherapy. J Clin Oncol 2013; 31: e220–2CrossRefPubMed Satzger I et al. Serious skin toxicity with the combination of BRAF-inhibitors and radiotherapy. J Clin Oncol 2013; 31: e220–2CrossRefPubMed
42.
Zurück zum Zitat Forschner A et al. Radiation recall dermatitis and radiation pneumonitis during treatment with vemurafenib. Melanoma Res 2014; 24: 512–6CrossRefPubMed Forschner A et al. Radiation recall dermatitis and radiation pneumonitis during treatment with vemurafenib. Melanoma Res 2014; 24: 512–6CrossRefPubMed
43.
Zurück zum Zitat Golian E et al. Cutaneous Complications of targeted melanoma therapy. Curr Treat Options Oncol 2016; 17: 57CrossRefPubMed Golian E et al. Cutaneous Complications of targeted melanoma therapy. Curr Treat Options Oncol 2016; 17: 57CrossRefPubMed
44.
Zurück zum Zitat Meurer M et al. Medikamentöse Therapie des malignen Melanoms. Hautarzt 2012; 63: 885–98CrossRef Meurer M et al. Medikamentöse Therapie des malignen Melanoms. Hautarzt 2012; 63: 885–98CrossRef
45.
Zurück zum Zitat Belum VR et al. Characterisation and management of dermatologic adverse events to agents targeting the PD-1 receptor. Eur J Cancer 2016; 60: 12–25CrossRefPubMedPubMedCentral Belum VR et al. Characterisation and management of dermatologic adverse events to agents targeting the PD-1 receptor. Eur J Cancer 2016; 60: 12–25CrossRefPubMedPubMedCentral
46.
Zurück zum Zitat Beck KE et al. Enterocolitis in patients with cancer after antibody blockade of cytotoxic T-lymphocyte-associated antigen 4. J Clin Oncol 2006; 24: 2283–9CrossRefPubMedPubMedCentral Beck KE et al. Enterocolitis in patients with cancer after antibody blockade of cytotoxic T-lymphocyte-associated antigen 4. J Clin Oncol 2006; 24: 2283–9CrossRefPubMedPubMedCentral
48.
Zurück zum Zitat Lacouture ME et al. Ipilimumab in patients with cancer and the management of dermatologic adverse events. J Am Acad Dermatol 2014; 71: 161–9CrossRefPubMed Lacouture ME et al. Ipilimumab in patients with cancer and the management of dermatologic adverse events. J Am Acad Dermatol 2014; 71: 161–9CrossRefPubMed
49.
50.
Zurück zum Zitat Teulings HE et al. Vitiligo-like depigmentation in patients with stage III–IV melanoma receiving immunotherapy and ist association with survival: a systematic review and meta-analysis. J Clin Oncol 2015; 33: 773–81CrossRefPubMed Teulings HE et al. Vitiligo-like depigmentation in patients with stage III–IV melanoma receiving immunotherapy and ist association with survival: a systematic review and meta-analysis. J Clin Oncol 2015; 33: 773–81CrossRefPubMed
Metadaten
Titel
Dermatologisches Nebenwirkungsmanagement zielgerichteter Onkologika
Schattenseiten der Targeted Therapy
verfasst von
Janina Below
PD Dr. med. Peter Arne Gerber
Publikationsdatum
17.07.2017
Verlag
Springer Medizin
Erschienen in
hautnah dermatologie / Ausgabe 4/2017
Print ISSN: 0938-0221
Elektronische ISSN: 2196-6451
DOI
https://doi.org/10.1007/s15012-017-2305-1

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