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05.08.2023 | Review Article

Schizophrenia in the genetic era: a review from development history, clinical features and genomic research approaches to insights of susceptibility genes

verfasst von: Ye Lv, Lin Wen, Wen-Juan Hu, Chong Deng, Hui-Wen Ren, Ya-Nan Bao, Bo-Wei Su, Ping Gao, Zi-Yue Man, Yi-Yang Luo, Cheng-Jie Li, Zhi-Xin Xiang, Bing Wang, Zhi-Lin Luan

Erschienen in: Metabolic Brain Disease | Ausgabe 1/2024

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Abstract

Schizophrenia is a devastating neuropsychiatric disorder affecting 1% of the world population and ranks as one of the disorders providing the most severe burden for society. Schizophrenia etiology remains obscure involving multi-risk factors, such as genetic, environmental, nutritional, and developmental factors. Complex interactions of genetic and environmental factors have been implicated in the etiology of schizophrenia. This review provides an overview of the historical origins, pathophysiological mechanisms, diagnosis, clinical symptoms and corresponding treatment of schizophrenia. In addition, as schizophrenia is a polygenic, genetic disorder caused by the combined action of multiple micro-effective genes, we further detail several approaches, such as candidate gene association study (CGAS) and genome-wide association study (GWAS), which are commonly used in schizophrenia genomics studies. A number of GWASs about schizophrenia have been performed with the hope to identify novel, consistent and influential risk genetic factors. Finally, some schizophrenia susceptibility genes have been identified and reported in recent years and their biological functions are also listed. This review may serve as a summary of past research on schizophrenia genomics and susceptibility genes (NRG1, DISC1, RELN, BDNF, MSI2), which may point the way to future schizophrenia genetics research. In addition, depending on the above discovery of susceptibility genes and their exact function, the development and application of antipsychotic drugs will be promoted in the future.

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Titel: Schizophrenia in the genetic era: a review from development history, clinical features and genomic research approaches to insights of susceptibility genes
verfasst von: Ye Lv
Lin Wen
Wen-Juan Hu
Chong Deng
Hui-Wen Ren
Ya-Nan Bao
Bo-Wei Su
Ping Gao
Zi-Yue Man
Yi-Yang Luo
Cheng-Jie Li
Zhi-Xin Xiang
Bing Wang
Zhi-Lin Luan
Publikationsdatum: 05.08.2023
Verlag: Springer US
Erschienen in: Metabolic Brain Disease / Ausgabe 1/2024
Print ISSN: 0885-7490
Elektronische ISSN: 1573-7365
DOI: https://doi.org/10.1007/s11011-023-01271-x

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Schizophrenia in the genetic era: a review from development history, clinical features and genomic research approaches to insights of susceptibility genes

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