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14.10.2019 | Nephrology - Review

Sclerostin: a new biomarker of CKD–MBD

verfasst von: Andreja Figurek, Merita Rroji, Goce Spasovski

Erschienen in: International Urology and Nephrology | Ausgabe 1/2020

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Abstract

The causes of the increased cardiovascular risk associated with kidney diseases partly reside in the chronic kidney disease–mineral bone disorder (CKD–MBD) syndrome. Three cardiovascular risk factors [hyperphosphatemia, vascular calcification, and elevated fibroblast growth factor 23 (FGF23)] levels have been discovered within the CKD–MBD over the last decades. In addition, sclerostin is recently presented as a new bone and vascular disease biomarker. This 22-kDa glycoprotein, secreted mainly by osteocytes, is a soluble inhibitor of the canonical Wnt pathway that has a pivotal role in bone biology and turnover. CKD patients are reported with higher levels of sclerostin, and levels decrease during dialysis. Sclerostin is associated with vascular calcification and CV risk in CKD, although data are still controversial. The question whether serum sclerostin has protective or deleterious role in CKD–MBD pathophysiology, and therefore in cardiovascular risk and overall mortality, is still open and needs to be answered. The standardization of assays and the establishment of a clear cut-off values when sclerostin starts to switch from physiological to pathophysiological role have to be another important step. Further research is needed also to define its relationship with other CKD–MBD biomarkers for future diagnostic and therapeutic strategies.
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Metadaten
Titel
Sclerostin: a new biomarker of CKD–MBD
verfasst von
Andreja Figurek
Merita Rroji
Goce Spasovski
Publikationsdatum
14.10.2019
Verlag
Springer Netherlands
Erschienen in
International Urology and Nephrology / Ausgabe 1/2020
Print ISSN: 0301-1623
Elektronische ISSN: 1573-2584
DOI
https://doi.org/10.1007/s11255-019-02290-3

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