Background
Methods
Data source
Sampled participants
Statistical analysis
Results
Demographic characteristics, comorbidities, and cumulative incidence of depression in the ST and non-ST groups
Variable | Scrub typhus | |
---|---|---|
No | Yes | |
N = 20,952 | N = 5238 | |
Sex | n (%) | n (%) |
Female | 7316 (34.9) | 1829 (34.9) |
Male | 13,636 (65.1) | 3409 (65.1) |
Age, mean (SD) | 46.4 (17.1) | 46.6 (16.9) |
Stratify age | ||
≤ 49 | 11,772 (56.2) | 2943 (56.2) |
50–65 | 5824 (27.8) | 1456 (27.8) |
65 + | 3356 (16.0) | 839 (16.0) |
Comorbidity | ||
Diabetes | 2088 (9.97) | 522 (9.97) |
Hypertension | 2908 (13.9) | 727 (13.9) |
Hyperlipidemia | 1064 (5.08) | 266 (5.08) |
CAD | 968 (4.62) | 242 (4.62) |
Stroke | 688 (3.28) | 172 (3.28) |
Incidence and HRs of depression and other risk factors in the ST and non-ST groups
Variable | Event | Person-years | Ratea | Crude HR (95% CI) | Adjusted HRb (95% CI) |
---|---|---|---|---|---|
Scrub typhus | |||||
No | 117 | 108,433 | 1.08 | 1.00 | 1.00 |
Yes | 45 | 26,905 | 1.67 | 1.55 (1.41, 1.70)* | 1.56 (1.42, 1.71)* |
Sex | |||||
Female | 72 | 46,692 | 1.54 | 1.52 (1.39, 1.65)* | 1.35 (1.24, 1.47)* |
Male | 90 | 88,645 | 1.02 | 1.00 | 1.00 |
Age, year | |||||
≤ 49 | 77 | 81,148 | 0.95 | 1.00 | 1.00 |
50–64 | 50 | 35,400 | 1.41 | 1.49 (1.35, 1.64)* | 1.10 (0.99, 1.22) |
65 + | 35 | 18,789 | 1.86 | 1.96 (1.76, 2.19)* | 1.26 (1.11, 1.42)* |
Diabetes | |||||
No | 133 | 124,334 | 1.07 | 1.00 | 1.00 |
Yes | 29 | 11,003 | 2.64 | 2.46 (2.21, 2.75)* | 1.53 (1.35, 1.73)* |
Hypertension | |||||
No | 125 | 120,702 | 1.04 | 1.00 | 1.00 |
Yes | 37 | 14,636 | 2.53 | 2.44 (2.21, 2.70)* | 1.41 (1.24, 1.59)* |
Hyperlipidemia | |||||
No | 141 | 129,514 | 1.09 | 1.00 | 1.00 |
Yes | 21 | 5823 | 3.61 | 3.31 (2.92, 3.76)* | 2.08 (1.81,2 .40)* |
CAD | |||||
No | 144 | 130,203 | 1.11 | 1.00 | 1.00 |
Yes | 18 | 5133 | 3.51 | 3.17 (2.77, 3.63)* | 1.51 (1.29, 1.76)* |
Stroke | |||||
No | 150 | 131,863 | 1.14 | 1.00 | 1.00 |
Yes | 12 | 3474 | 3.45 | 3.04 (2.58, 3.57)* | 1.52 (1.27, 1.81)* |
Incidence and HRs of depression stratified by sex, age, and comorbidities in the ST and non-ST groups
Variable | Without scrub typhus | With scrub typhus | |||||||
---|---|---|---|---|---|---|---|---|---|
Event | Person-years | Ratea | Crude HR | Event | Person-years | Ratea | Crude HR (95% CI) | Adjusted HRb (95% CI) | |
Sex | |||||||||
Female | 51 | 37,459 | 1.36 | Reference | 21 | 9232 | 2.27 | 1.67 (1.43, 1.95)* | 1.68 (1.45, 1.96)* |
Male | 66 | 70,973 | 0.93 | Reference | 24 | 17,672 | 1.36 | 1.46 (1.29, 1.65)* | 1.46 (1.29, 1.64)* |
P for interaction | 0.16 | ||||||||
Stratify age | |||||||||
≤ 49 | 52 | 65,025 | 0.80 | Reference | 25 | 16,123 | 1.55 | 1.94 (1.71, 2.19)* | 1.95 (1.72, 2.20)* |
50–64 | 35 | 28,372 | 1.23 | Reference | 15 | 7028 | 2.13 | 1.73 (1.46, 2.06)* | 1.73 (1.46, 2.05)* |
65 + | 30 | 15,036 | 2.00 | Reference | 5 | 3753 | 1.33 | 0.67 (0.50, 1.02) | 0.69 (0.52, 1.01) |
P for interaction | < 0.001 | ||||||||
Comorbidityc | |||||||||
No | 61 | 87,465 | 0.70 | Reference | 31 | 21,555 | 1.44 | 2.06 (1.85, 2.29)* | 2.06 (1.85, 2.29)* |
Yes | 56 | 20,968 | 2.67 | Reference | 14 | 5350 | 2.62 | 0.98 (0.80, 1.20) | 0.98 (0.80, 1.20) |
P for interaction | < 0.001 |