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24.05.2024 | Note

Scutellaria Root extract-induced hepatocytotoxicity can be controlled by regulating its baicalin content

verfasst von: Naohiro Oshima, Kosuke Kusamori, Ryo Takasaki, Moe Takeda, Yuri Katsurada, Takumi Nose, Kazuki Okoshi, Makiya Nishikawa, Noriyasu Hada

Erschienen in: Journal of Natural Medicines | Ausgabe 4/2024

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Abstract

Scuellaria Root (SR, root of Scutellaria baicalensis), which has potent anti-inflammatory effects, is a component of useful Kampo formulae. Albeit a low frequency, SR induces serious interstitial pneumonia and liver dysfunction. In this study, to control the adverse effects of SR, we investigated the causal constituent responsible for its hepatocytotoxicity and aimed to develop a method to control it. As a result, we revealed that the hepatocytotoxicity of SR was correlated with its baicalin content, a major constituent in SR. It was confirmed by preparing a baicalin-free SR extract, which exhibited reduced hepatocytotoxicity. The addition of baicalin to the baicalin-free SR extract restored the hepatocytotoxicity, indicating that the hepatocytotoxicity of SR is dependent on its baicalin content. Thus, SR extract-induced hepatocytotoxicity can be controlled by regulating its baicalin content.

Graphical abstract

The Ministry of Health Labour and Welfare of Japan (2021) The Japanese Pharmacopoeia. The Ministry of Health Labour and Welfare of Japan, Japan

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Titel: Scutellaria Root extract-induced hepatocytotoxicity can be controlled by regulating its baicalin content
verfasst von: Naohiro Oshima
Kosuke Kusamori
Ryo Takasaki
Moe Takeda
Yuri Katsurada
Takumi Nose
Kazuki Okoshi
Makiya Nishikawa
Noriyasu Hada
Publikationsdatum: 24.05.2024
Verlag: Springer Nature Singapore
Erschienen in: Journal of Natural Medicines / Ausgabe 4/2024
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-024-01814-1

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Note

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Scutellaria Root extract-induced hepatocytotoxicity can be controlled by regulating its baicalin content

Abstract

Graphical abstract

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