Background
Methods
Data source
Observed survival
Statistical methods
Results
Study population
Site group | RCC | LCC | P value | Rectal cancer |
---|---|---|---|---|
Number | 2144 (43.1%) | 1262 (25.4%) | 1430 (28.7%) | |
Mean Age development of 2nd cancer (years) | 76.0 | 74.0 | 0.146 | 70.0 |
Sex | 0.113 | |||
Male | 1017 (48.1%) | 689 (54.6%) | 813 (56.9%) | |
Female | 1097 (51.9%) | 573 (45.4%) | 617 (43.1%) | |
Race | ||||
Black | 236 (11.2%) | 147 (11.6%) | 190 (13.3%) | |
White | 1563 (73.9%) | 873 (69.2%) | 882 (61.7%) | |
Hispanic/Latino | 141 (6.7%) | 115 (9.1%) | 172 (12.0%) | |
Asian or Pacific Islander and others | 173 (8.2%) | 126 (10.0%) | 182 (12.7%) | |
Unknown | 1 (0.1%) | 1 (0.1%) | 4 (0.3%) | |
SEER staging | ||||
Localized | 1066 (50.%) | 558 (44.2%) | 0.061 | 660 (46.2%) |
Regional | 670 (31.7%) | 373 (29.6%) | 341 (23.8%) | |
Distant | 245 (11.6%) | 218 (17.3%) | 218 (15.2%) | |
Unknown | 133 (6.3%) | 113 (9.0%) | 211 (14.8%) | |
Surgery | ||||
No | 219 (10.4%) | 180 (14.3%) | 405 (28.3%) | |
Yes | 1892 (89.5%) | 1079 (85.5%) | 1018 (71.2%) | |
Unknown | 7 (0.5%) | |||
Pathology grade | 0.312 | |||
Well differentiated | 200 (9.5%) | 127 (10.1%) | 115 (8.0%) | |
Moderately differentiated | 1200 (56.8%) | 749 (59.4%) | 769 (53.8%) | |
Poorly differentiated | 422 (20.0%) | 169 (13.4%) | 172 (12.0%) | |
Undifferentiated | 27 (1.3%) | 13 (1.0%) | 11 (0.8%) | |
Unknown | 265 (12.5%) | 204 (16.2%) | 363 (25.4%) | |
Calendar year | ||||
1992–2002 | 801 (37.9%) | 490 (38.8%) | 460 (32.2%) | |
2003–2012 | 1313 (62.1%) | 772 (61.2%) | 970 (67.8%) | |
Median time to secondary cancer (months) | 38.0 | 28.0 | 31.0 |
SPCRC trends
Identifying factors associated with SPCRC risk
Cancer type | Univariate Cox Regression | Multivariate Cox Regression | ||||
---|---|---|---|---|---|---|
HR | 95% CI |
P
| HR | 95% CI |
P
| |
History of IPCRC | < 0.001 | < 0.001 | ||||
RCC | 1.000 | 1.000 | 1.000 | 1.000 | ||
LCC | 1.362 | 1.264–1.468 | < 0.001 | 1.369 | 1.269–1.477 | < 0.001 |
Rectosigmoid colon | 1.031 | 0.951–1.118 | < 0.454 | 1.090 | 1.003–1.184 | 0.041 |
Age at diagnosis | < 0.001 | < 0.001 | ||||
< 40 | 1.000 | 1.000 | 1.000 | 1.000 | ||
40–49 | 1.026 | 0.800–1.315 | 0.839 | 1.018 | 0.794–1.305 | 0.890 |
50–59 | 1.027 | 0.816–1.293 | 0.820 | 0.954 | 0.799–1.268 | 0.954 |
60–69 | 1.352 | 1.082–1.691 | 0.008 | 1.342 | 1.073–1.679 | 0.010 |
70–79 | 1.516 | 1.215–1.892 | < 0.001 | 1.541 | 1.234–1.925 | < 0.001 |
> 80 | 1.257 | 1.003–1.576 | 0.047 | 1.339 | 1.066–1.680 | 0.012 |
Sex | ||||||
Female vs. Male | 0.928 | 0.870–0.989 | 0.021 | 0.930 | 0.871–0.992 | 0.028 |
Race | < 0.001 | < 0.001 | ||||
Black | 1.000 | 1.000 | 1.000 | 1.000 | < 0.001 | |
White | 0.490 | 0.447–0.536 | < 0.001 | 0.490 | 0.447–0.536 | < 0.001 |
Hispanic/Latino | 0.581 | 0.508–0.664 | < 0.001 | 0.604 | 0.528–0.690 | < 0.001 |
Asian or Pacific Islander and others | 0.799 | 0.710–0.899 | < 0.001 | 0.798 | 0.710–0.898 | < 0.001 |
SEER staging | 0.001 | 0.007 | ||||
Localized | 1.000 | 1.000 | 1.000 | 1.000 | ||
Regional | 0.947 | 0.882–1.017 | 0.159 | 0.943 | 0.878–1.013 | 0.109 |
Distant | 1.116 | 1.023–1.116 | 0.013 | 1.087 | 0.996–1.186 | 0.061 |
If surgery | ||||||
Yes vs. No | 1.685 | 1.409–2.016 | < 0.001 | 1.657 | 1.383–1.985 | < 0.001 |
Pathology grade | < 0.001 | < 0.001 | ||||
Well differentiated | 1.000 | 1.000 | 1.000 | 1.000 | ||
Moderately differentiated | 0.871 | 0.787–0.963 | 0.007 | 0.868 | 0.785–0.961 | 0.006 |
Poorly differentiated | 0.775 | 0.686–0.875 | < 0.001 | 0.814 | 0.720–0.919 | 0.001 |
Undifferentiated | 0.487 | 0.329–0.719 | < 0.001 | 0.524 | 0.354–0.775 | 0.001 |