nach oben

Journal of Natural Medicines

Erschienen in:

24.08.2019 | Original Paper

Sedative effects of the essential oil from the leaves of Lantana camara occurring in the Republic of Benin via inhalation in mice

verfasst von: Godfried Dougnon, Michiho Ito

Erschienen in: Journal of Natural Medicines | Ausgabe 1/2020

Einloggen, um Zugang zu erhalten

Abstract

Lantana camara Linn. (Verbenaceae) is used traditionally for its numerous medicinal properties such as antimalarial, antibacterial, anticancer and anti-inflammatory. In the present study, we investigated the chemical composition of essential oil from the leaves of L. camara (LCEO) occurring in the Republic of Benin (West Africa) in comparison with LCEOs from other regions; evaluated its sedative effects in mice via inhalation administration; and identified the compounds responsible for activity. LCEO was extracted by hydrodistillation and chemical analyses of the oil were performed by GC and GC/MS. The oil was dominated by monoterpene hydrocarbons (60.58%) and oxygenated monoterpenes (33.39%), among which sabinene (38.81%) and 1,8-cineole (28.90%) were the most abundant. LCEO administered via inhalation to mice significantly decreased locomotor activity in a dose-dependent manner, mainly at the doses of 0.0004 and 0.04 mg per 400 μL of triethyl citrate (TEC). The oil was fractionated to give two fractions, which were further investigated, and revealed that both sabinene and 1,8-cineole were the principal active compounds. The results of the present study indicated that via inhalation administration, LCEO and its main constituents could be considered as promising candidates for the management of dementia, insomnia, attention deficit hyperactivity disorder and other central nervous system-associated diseases.

Graphic abstract

Nur mit Berechtigung zugänglich

Sharma O, Dawra R, Pattabhi V (1991) Molecular structure, polymorphism and toxicity of lantadene A, the pentacyclic triterpenoid from the hepatotoxic plant, Lantana camara. J Biochem Toxicol 6:57–63CrossRefPubMed

Khan M, Mahmood A, Alkhathlan HZ (2016) Characterization of leaves and flowers volatile constituents of Lantana camara growing in central region of Saudi Arabia. Arab J Chem 9:764–774. https://doi.org/10.1016/j.arabjc.2015.11.005 CrossRef

Sonibare OO, Effiong I (2008) Antibacterial activity and cytotoxicity of essential oil of Lantana camara leaves from Nigeria. Afr J Biotechnol 7:2618–2620

Weenen H, Nkunya H, Bray H et al (1990) Antimalarial activity of Tanzanian medicinal plants. Planta Med 56:368–370CrossRefPubMed

Deena MJ, Thoppil JE (2000) Antimicrobial activity of the essential oil of Lantana camara. Fitoterapia 71:453–455CrossRefPubMed

Alitonou G, Avlessi F, Bokossa I et al (2004) Chemical composition and biological activities of essential oil from Lantana camara Linn. C R Chimie 7:1101–1105CrossRef

Fujiwara Y, Ito M (2015) Synergistic effect of fragrant herbs in Japanese scent sachets. Planta Med 81:193–199. https://doi.org/10.1055/s-0034-1396138 CrossRefPubMed

Ito K, Ito M (2011) Sedative effects of vapor inhalation of the essential oil of Microtoena patchoulii and its related compounds. J Nat Med 65:336–343. https://doi.org/10.1007/s11418-010-0502-x CrossRefPubMed

Sinha D, Efron D (2005) Complementary and alternative medicine use in children with attention deficit hyperactivity disorder. J Paediatr Child Health 41:23–26. https://doi.org/10.1111/j.1440-1754.2005.00530.x CrossRefPubMed

10.

Takemoto H, Ito M, Shiraki T et al (2008) Sedative effects of vapor inhalation of agarwood oil and spikenard extract and identification of their active components. J Nat Med 62:41–46CrossRefPubMed

11.

Tankam JM, Ito M (2013) Inhalation of the essential oil of Piper guineense from Cameroon shows sedative and anxiolytic-like effects in mice. Biol Pharm Bull 36:1608–1614. https://doi.org/10.1248/bpb.b13-00491 CrossRefPubMed

12.

Ogawa K, Miyoshi T, Kitayama T, Ito M (2014) Locomotor-reducing effects and structural characteristics of inhaled zerumbone and tetrahydrozerumbone derivatives. Biol Pharm Bull 37:1559–1563CrossRefPubMed

13.

Tankam JM, Ito M (2014) Sedative, anxiolytic and antidepressant-like effects of inhalation of the essential oil of Ocimum gratissimum L. from Cameroon in mice. J Pharmacogn Phytochem 2:1–9

14.

Ogawa K, Yabe H, Kitayama T, Ito M (2016) Locomotor-reducing activity of sesquiterpenes related to Zingiber zerumbet essential oil and hexahydrozerumbone derivatives. Biol Pharm Bull 39:1077–1080. https://doi.org/10.1248/bpb.b16-00141 CrossRefPubMed

15.

Karimi AG, Ito M (2012) Sedative effect of vapor inhalation of essential oil from Heracleum afghanicum Kitamura seeds. J Essent Oil Res 24:571–577. https://doi.org/10.1080/10412905.2012.728085 CrossRef

16.

Miyoshi T, Ito M, Kitayama T et al (2013) Sedative effects of inhaled benzylacetone and structural features contributing to its activity. Biol Pharm Bull 36:1474–1481CrossRefPubMed

17.

Ito K, Akahoshi Y, Ito M, Kaneko S (2016) Sedative effects of inhaled essential oil components of traditional fragrance Pogostemon cablin leaves and their structure-activity relationships. J Tradit Complement Med 6:140–145. https://doi.org/10.1016/j.jtcme.2015.01.004 CrossRefPubMed

18.

Noudogbessi J, Chalard P, Figueredo G et al (2013) Chemical compositions and physical characteristics of volatile extracts of leaves of Psidium guajava Linn and Lantana camara Linn of Benin. Res J Pharm Biol Chem Sci 4:28–38

19.

Kasali A, Ekundayo O, Paul C et al (2004) Essential oil of Lantana camara L. var. aculeate from Nigeria. J Essent Oil Res 16:582–584CrossRef

20.

Ngassoum MB, Yonkeu S, Jirovetz L et al (1999) Chemical composition of essential oils of Lantana camara leaves and flowers from Cameroon and Madagascar. Flavour Frag J 14:245–250CrossRef

21.

Dua V, Pandey A, Dash A (2010) Adulticidal activity of essential oil of Lantana camara leaves against mosquitoes. Indian J Med Res 131:434–439PubMed

22.

da Silva M, Andrade E, Zoghbi M et al (1999) Essential oils of Lantana camara L. occurring at North Brazil. Flavour Fragr J 14:208–210CrossRef

23.

Sousa EO, Colares AV, Rodrigues FF et al (2010) Effect of collection time on essential oil composition of Lantana camara Linn (Verbenaceae) growing in Brazil Northeastern. Rec Nat Prod 4:31–37

24.

Pino J, Marbot R, Rosado A et al (2004) Chemical composition of the essential oil of Lantana camara L. from Cuba. J Essent Oil Res 16:216–218CrossRef

25.

Saleh M (1974) Gas-chromatographic analysis of the essential oil of Lantana camara L. varieties. Planta Med 25:373–375. https://doi.org/10.1055/s-0028-1097957 CrossRefPubMed

26.

Sundufu AJ, Shoushan H (2004) Chemical composition of the essential oils of Lantana camara L. occurring in South China. Flavour Fragr J 19:229–232. https://doi.org/10.1002/ffj.1292 CrossRef

27.

Randrianalijaona JA, Ramanoelina PAR, Rasoarahona JRE, Gaydou EM (2005) Seasonal and chemotype influences on the chemical composition of Lantana camara L. Anal Chim Acta 545:46–52. https://doi.org/10.1016/j.aca.2005.04.028 CrossRef

28.

Jawonisi IO, Adoga GI (2013) Chemical constituents of essential oil of Lantana camara Linn. leaves. Br J Pharmacol Toxicol 4:155–157CrossRef

29.

Shah SMM, Ullah F, Shah SMH et al (2012) Analysis of chemical constituents and antinociceptive potential of essential oil of Teucrium stocksianum Bioss collected from the North West of Pakistan. BMC Complement Altern Med 12:1200. https://doi.org/10.1186/1472-6882-12-244 CrossRef

30.

Harraz FM, Hammoda HM, El Ghazouly MG et al (2015) Chemical composition, antimicrobial and insecticidal activities of the essential oils of Conyza linifolia and Chenopodium ambrosioides. Nat Prod Res 29:879–882. https://doi.org/10.1080/14786419.2014.988714 CrossRefPubMed

31.

Xu J, Hu Z-Q, Wang C et al (2014) Acute and subacute toxicity study of 1,8-cineole in mice. Int J Clin Exp Pathol 7:1495–1501PubMedPubMedCentral

32.

Robert T, Rodney Y (2014) Essential oil safety. Churchill Livingstone, Elsevier

33.

de Sousa DP, Nóbrega FF, de Morais LC, de Almeida RN (2009) Evaluation of the anticonvulsant activity of terpinen-4-ol. Z Naturforsch C 64:1–5. https://doi.org/10.1515/znc-2009-1-201 CrossRefPubMed

34.

Becker AG, Parodi TV, Heldwein CG et al (2012) Transportation of silver catfish, Rhamdia quelen, in water with eugenol and the essential oil of Lippia alba. Fish Physiol Biochem 38:789–796. https://doi.org/10.1007/s10695-011-9562-4 CrossRefPubMed

35.

Ash M, Ash I (2004) Handbook of green chemicals. Synapse Info Resources, Washington (DC)

36.

Muthukumaran P, Kumar SK, Ravichandran K (2017) Phytochemical screening, GC-MS, FT-IR analysis of methanolic extract of Curcuma caesia Roxb (black turmeric). Phcog J 9:952–956CrossRef

37.

Zamyad M, Abasnejad M, Esmaeili-Mahani S, Mostafavi A (2016) Alpha-pinene as the main component of Ducrosia anethifolia (Boiss) essential oil is responsible for its effect on locomotor activity in rats. Avicenna J Neurol Psychol Physiol 3:1–6. https://doi.org/10.17795/ajnpp-38787 CrossRef

38.

Yang H, Woo J, Pae AN et al (2016) α-Pinene, a major constituent of pine tree oils, enhances non-rapid eye movement sleep in mice through GABAA-benzodiazepine receptors. Mol Pharmacol 90:530–539. https://doi.org/10.1124/mol.116.105080 CrossRefPubMed

39.

Bahi A, Al Mansouri S, Al Memari E et al (2014) Caryophyllene, a CB2 receptor agonist produces multiple behavioral changes relevant to anxiety and depression in mice. Physiol Behav 135:119–124CrossRefPubMed

40.

Hirai M, Ito M (2019) Sedative effects of the essential oil and headspace air of Ocimum basilicum by inhalation in mice. J Nat Med 73:283–288. https://doi.org/10.1007/s11418-018-1253-3 CrossRefPubMed

41.

Anas S, Anton A, Mustarichie R (2010) Identification of compounds in the essential oil of Nutmeg seeds (Myristica fragrans Houtt.) that inhibit locomotor activity in mice. Int J Mol Sci 11:4771–4781CrossRef

42.

Yao QS, Chiou GC (1993) Inhibition of crystallins-induced inflammation in rabbit eyes with five phytogenic compounds. Acta Pharmacol Sin 14:13–17

43.

Kirchner K, Wisniewski AJ, Cruz AB et al (2010) Chemical composition and antimicrobial activity of Hedyosmum brasiliense Miq., Chloranthaceae, essential oil. Rev Bras Farmacogn 20:692–699. https://doi.org/10.1590/S0102-695X2010005000005 CrossRef

44.

Coelho-de-Souza L, Leal-Cardoso J, de Abreu Matos F et al (2005) Relaxant effects of the essential oil of Eucalyptus tereticornis and its main constituent 1,8-cineole on guinea-pig tracheal smooth muscle. Planta Med 71:1173–1175CrossRefPubMed

45.

Santos F, Rao V (2000) Antiinflammatory and antinociceptive effects of 1,8-cineole a terpenoid oxide present in many plant essential oils. Phytother Res 14:240–244CrossRefPubMed

46.

Teixeira GFD, Júnior RCPL, Silveira ER et al (2008) Sedative effect of Eucalyptus Urophylla and E. Brassiana in mice. Nat Prod Commun 3:1539–1542. https://doi.org/10.1177/1934578X0800300928 CrossRef

47.

Galindo LA, de Moraes Pultrini A, Costa M (2010) Biological effects of Ocimum gratissimum L. are due to synergic action among multiple compounds present in essential oil. J Nat Med 64:436–441. https://doi.org/10.1007/s11418-010-0429-2 CrossRefPubMed

Titel: Sedative effects of the essential oil from the leaves of Lantana camara occurring in the Republic of Benin via inhalation in mice
verfasst von: Godfried Dougnon
Michiho Ito
Publikationsdatum: 24.08.2019
Verlag: Springer Singapore
Erschienen in: Journal of Natural Medicines / Ausgabe 1/2020
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-019-01358-9

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Sedative effects of the essential oil from the leaves of Lantana camara occurring in the Republic of Benin via inhalation in mice

Abstract

Graphic abstract

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Graphic abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 1/2020

Effect of heat processing on the chemical constituents and NO-suppressing activity of Bletilla Tuber

Naringenin suppresses neutrophil infiltration into adipose tissue in high-fat diet-induced obese mice

Four new cucurbitane-type triterpenes from Momordica charantia L. with their cytotoxic activities and protective effects on H2O2-damaged pancreatic cells

Cynandione A from Cynanchum wilfordii inhibits hepatic de novo lipogenesis by activating the LKB1/AMPK pathway in HepG2 cells

Antiinflammatory constituents of Atractylodes chinensis rhizome improve glomerular lesions in immunoglobulin A nephropathy model mice

Chemical components from the twigs of Caesalpinia latisiliqua and their antiviral activity