Skip to main content
Erschienen in: Head and Neck Pathology 1/2021

15.03.2021 | Special Issue: Pediatric Pathology

Selected Topics in the Pathology of the Thyroid and Parathyroid Glands in Children and Adolescents

verfasst von: John A. Ozolek

Erschienen in: Head and Neck Pathology | Ausgabe 1/2021

Einloggen, um Zugang zu erhalten

Abstract

The goals of this chapter in keeping with the overall general themes of this special edition will be (1) to highlight aspects of development of the thyroid and parathyroid glands with particular focus on the role and contribution of the neural crest (or not) and how this may impact on the pathology that is seen, (2) to emphasize those lesions particularly more commonly arising in the pediatric population that actually generate specimens that the surgical pathologist would encounter, and (3) highlight more in depth specific lesions associated with heritable syndromes or specific gene mutations since the heritable syndromes tends to manifest in the pediatric age group. In this light, the other interesting areas of pediatric thyroid disease including medical thyroid diseases, congenital hypothyroidism, anatomic variants and aberrations of development that lead to structural anomalies will not be emphasized here.
Literatur
9.
Zurück zum Zitat Nikiforov Y, Biddinger PW, Thompson LDR. Diagnostic pathology and molecular genetics of the thyroid. 2nd ed. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins; 2012. Nikiforov Y, Biddinger PW, Thompson LDR. Diagnostic pathology and molecular genetics of the thyroid. 2nd ed. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins; 2012.
27.
Zurück zum Zitat Jarzab B, Handkiewicz-Junak D. Differentiated thyroid cancer in children and adults: same or distinct disease? Hormones (Athens). 2007;6(3):200–9.PubMed Jarzab B, Handkiewicz-Junak D. Differentiated thyroid cancer in children and adults: same or distinct disease? Hormones (Athens). 2007;6(3):200–9.PubMed
32.
Zurück zum Zitat Pachnis V, Mankoo B, Costantini F. Expression of the c-ret proto-oncogene during mouse embryogenesis. Development. 1993;119(4):1005–17.PubMed Pachnis V, Mankoo B, Costantini F. Expression of the c-ret proto-oncogene during mouse embryogenesis. Development. 1993;119(4):1005–17.PubMed
45.
Zurück zum Zitat Garofola C, Jamal Z, Gross GP. Cowden Disease (Multiple Hamartoma Syndrome). StatPearls. Treasure Island (FL)2020. Garofola C, Jamal Z, Gross GP. Cowden Disease (Multiple Hamartoma Syndrome). StatPearls. Treasure Island (FL)2020.
48.
Zurück zum Zitat Lloyd RV, Osamura RY, Klöppel Gn, Rosai J, World Health O, International Agency for Research on C. WHO classification of tumours of endocrine organs. 2017 Lloyd RV, Osamura RY, Klöppel Gn, Rosai J, World Health O, International Agency for Research on C. WHO classification of tumours of endocrine organs. 2017
54.
Zurück zum Zitat Andriescu EC, Caruntu ID, Giusca SE, Lozneanu L, Ciobanu Apostol DG. Prognostic significance of cell-adhesion molecules in histological variants of papillary thyroid carcinoma. Rom J Morphol Embryol. 2018;59(3):721–7.PubMed Andriescu EC, Caruntu ID, Giusca SE, Lozneanu L, Ciobanu Apostol DG. Prognostic significance of cell-adhesion molecules in histological variants of papillary thyroid carcinoma. Rom J Morphol Embryol. 2018;59(3):721–7.PubMed
64.
Zurück zum Zitat Brehar AC, Terzea DC, Ioachim DL, Procopiuc C, Brehar FM, Bulgar AC, et al. Cribriform-morular variant of papillary thyroid carcinoma at pediatric age - case report and review of the literature. Rom J Morphol Embryol. 2016;57(2):531–7.PubMed Brehar AC, Terzea DC, Ioachim DL, Procopiuc C, Brehar FM, Bulgar AC, et al. Cribriform-morular variant of papillary thyroid carcinoma at pediatric age - case report and review of the literature. Rom J Morphol Embryol. 2016;57(2):531–7.PubMed
68.
Zurück zum Zitat Tsuji H, Yasuoka H, Nakamura Y, Hirokawa M, Hiroshima T, Sakamaki Y, et al. Aggressive cribriform-morular variant of papillary thyroid carcinoma: report of an unusual case with pulmonary metastasis displaying poorly differentiated features. Pathol Int. 2018;68(12):700–5. https://doi.org/10.1111/pin.12728.CrossRefPubMed Tsuji H, Yasuoka H, Nakamura Y, Hirokawa M, Hiroshima T, Sakamaki Y, et al. Aggressive cribriform-morular variant of papillary thyroid carcinoma: report of an unusual case with pulmonary metastasis displaying poorly differentiated features. Pathol Int. 2018;68(12):700–5. https://​doi.​org/​10.​1111/​pin.​12728.CrossRefPubMed
69.
Zurück zum Zitat Ito Y, Ishikawa H, Kihara M, Hirokawa M, Kiyota N, Kasahara T, et al. Control of lung metastases and colon polyposis with lenvatinib therapy in a patient with Cribriform-Morular variant of papillary thyroid carcinoma and an APC gene mutation: a case study. Thyroid. 2019;29(10):1511–7. https://doi.org/10.1089/thy.2019.0121.CrossRefPubMed Ito Y, Ishikawa H, Kihara M, Hirokawa M, Kiyota N, Kasahara T, et al. Control of lung metastases and colon polyposis with lenvatinib therapy in a patient with Cribriform-Morular variant of papillary thyroid carcinoma and an APC gene mutation: a case study. Thyroid. 2019;29(10):1511–7. https://​doi.​org/​10.​1089/​thy.​2019.​0121.CrossRefPubMed
71.
Zurück zum Zitat Eng C. PTEN Hamartoma Tumor Syndrome. In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens K et al., editors. GeneReviews((R)). Seattle (WA)1993. Eng C. PTEN Hamartoma Tumor Syndrome. In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens K et al., editors. GeneReviews((R)). Seattle (WA)1993.
76.
Zurück zum Zitat Cho U, Mete O, Kim MH, Bae JS, Jung CK. Molecular correlates and rate of lymph node metastasis of non-invasive follicular thyroid neoplasm with papillary-like nuclear features and invasive follicular variant papillary thyroid carcinoma: the impact of rigid criteria to distinguish non-invasive follicular thyroid neoplasm with papillary-like nuclear features. Mod Pathol. 2017;30(6):810–25. https://doi.org/10.1038/modpathol.2017.9.CrossRefPubMed Cho U, Mete O, Kim MH, Bae JS, Jung CK. Molecular correlates and rate of lymph node metastasis of non-invasive follicular thyroid neoplasm with papillary-like nuclear features and invasive follicular variant papillary thyroid carcinoma: the impact of rigid criteria to distinguish non-invasive follicular thyroid neoplasm with papillary-like nuclear features. Mod Pathol. 2017;30(6):810–25. https://​doi.​org/​10.​1038/​modpathol.​2017.​9.CrossRefPubMed
91.
Zurück zum Zitat de Graaf P, van der Linde EM, Rosier P, Izeta A, Sievert KD, Bosch J, et al. Systematic review to compare urothelium differentiation with urethral epithelium differentiation in fetal development, as a basis for tissue engineering of the Male Urethra. Tissue Eng Part B. 2017;23(3):257–67. https://doi.org/10.1089/ten.TEB.2016.0352.CrossRef de Graaf P, van der Linde EM, Rosier P, Izeta A, Sievert KD, Bosch J, et al. Systematic review to compare urothelium differentiation with urethral epithelium differentiation in fetal development, as a basis for tissue engineering of the Male Urethra. Tissue Eng Part B. 2017;23(3):257–67. https://​doi.​org/​10.​1089/​ten.​TEB.​2016.​0352.CrossRef
92.
Zurück zum Zitat Hazard JB. The C cells (parafollicular cells) of the thyroid gland and medullary thyroid carcinoma. A Rev Am J Pathol. 1977;88(1):213–50. Hazard JB. The C cells (parafollicular cells) of the thyroid gland and medullary thyroid carcinoma. A Rev Am J Pathol. 1977;88(1):213–50.
93.
Zurück zum Zitat Wenig BM. Atlas of Head and Neck Pathology. Elsevier Health Sciences; 2015. Wenig BM. Atlas of Head and Neck Pathology. Elsevier Health Sciences; 2015.
109.
Zurück zum Zitat Niramitmahapanya S, Deerochanawong C, Sarinnapakorn V, Sunthornthepvarakul T, Pingsuthiwong S, Athipan P, et al. Somatic HRPT2 mutation (Arg234X) of parathyroid carcinoma associated with slipped capital femoral epiphysis: a first case report. J Med Assoc Thai. 2016;99(Suppl 2):S201–5.PubMed Niramitmahapanya S, Deerochanawong C, Sarinnapakorn V, Sunthornthepvarakul T, Pingsuthiwong S, Athipan P, et al. Somatic HRPT2 mutation (Arg234X) of parathyroid carcinoma associated with slipped capital femoral epiphysis: a first case report. J Med Assoc Thai. 2016;99(Suppl 2):S201–5.PubMed
110.
Zurück zum Zitat Rahman MM, Karim SS, Joarder AI, Mubin S, Abir MM, Morshed MS. Parathyroid carcinoma in a 10 years old female child. Mymensingh Med J. 2015;24(3):619–23.PubMed Rahman MM, Karim SS, Joarder AI, Mubin S, Abir MM, Morshed MS. Parathyroid carcinoma in a 10 years old female child. Mymensingh Med J. 2015;24(3):619–23.PubMed
112.
Zurück zum Zitat Schantz A, Castleman B. Parathyroid carcinoma: A study of 70 cases. Cancer. 1973;31(3):600–5.CrossRef Schantz A, Castleman B. Parathyroid carcinoma: A study of 70 cases. Cancer. 1973;31(3):600–5.CrossRef
113.
117.
Zurück zum Zitat Kelly TG, Shattuck TM, Reyes-Mugica M, Stewart AF, Simonds WF, Udelsman R, et al. Surveillance for early detection of aggressive parathyroid disease: carcinoma and atypical adenoma in familial isolated hyperparathyroidism associated with a germline HRPT2 mutation. J Bone Miner Res. 2006;21(10):1666–71. https://doi.org/10.1359/jbmr.060702.CrossRefPubMed Kelly TG, Shattuck TM, Reyes-Mugica M, Stewart AF, Simonds WF, Udelsman R, et al. Surveillance for early detection of aggressive parathyroid disease: carcinoma and atypical adenoma in familial isolated hyperparathyroidism associated with a germline HRPT2 mutation. J Bone Miner Res. 2006;21(10):1666–71. https://​doi.​org/​10.​1359/​jbmr.​060702.CrossRefPubMed
118.
Zurück zum Zitat Rosai J, DeLellis R, Carcangiu M, Frable W, Tallina G. Tumors of the thyroid and parathyroid glands. 4th ed. AFIP Atlas of Tumor Pathology. ARP Press; 2014 Rosai J, DeLellis R, Carcangiu M, Frable W, Tallina G. Tumors of the thyroid and parathyroid glands. 4th ed. AFIP Atlas of Tumor Pathology. ARP Press; 2014
Metadaten
Titel
Selected Topics in the Pathology of the Thyroid and Parathyroid Glands in Children and Adolescents
verfasst von
John A. Ozolek
Publikationsdatum
15.03.2021
Verlag
Springer US
Erschienen in
Head and Neck Pathology / Ausgabe 1/2021
Elektronische ISSN: 1936-0568
DOI
https://doi.org/10.1007/s12105-020-01274-5

Weitere Artikel der Ausgabe 1/2021

Head and Neck Pathology 1/2021 Zur Ausgabe

Proceedings of the North American Society of Head and Neck Pathology, Baltimore, MD, March 17, 2021

The Most Common Mistake in Laryngeal Pathology and How to Avoid it

Neu im Fachgebiet Pathologie