nach oben

Acta Neurochirurgica

Erschienen in:

06.08.2016 | Review Article - Brain Tumors

Selective 5-aminolevulinic acid-induced protoporphyrin IX fluorescence in Gliomas

verfasst von: Ruichong Ma, Colin Watts

Erschienen in: Acta Neurochirurgica | Ausgabe 10/2016

Einloggen, um Zugang zu erhalten

Abstract

Malignant gliomas are locally invasive tumors that offer a poor prognosis. Evidence shows that complete resection of the tumor at the time of surgery confers a significant improvement in overall survival. In recent years, 5- aminolevulinic acid (ALA)-induced fluorescence has been used by neurosurgeons to good effect in increasing the rate of complete resection. Despite the considerable interest in the use of 5-ALA in fluorescence-guided neurosurgery, the mechanisms behind the accumulation of Protoporphyrin IX (PpIX) in neoplastic tissue are unclear. In this review, we summarize the evidence in the literature on the mechanisms underlying the selective production of PpIX with a specific focus on gliomas.

Albert FK, Forsting M, Sartor K, Adams HP, Kunze S, Salcman M, Wilson CB (1994) Early postoperative magnetic resonance imaging after resection of malignant glioma: objective evaluation of residual tumor and its influence on regrowth and prognosis. Neurosurgery 34(1):41–45

Andoh Y, Suzuki H, Araki M, Mizutani A, Ohashi T, Okumura T, Adachi Y, Ikehara S, Taketani S (2004) Low- and high-level expressions of heme oxygenase-1 in cultured cells under uninduced conditions. Biochem Biophys Res Commun 320:722–729CrossRefPubMed

Beck TJ, Kreth FW, Beyer W, Mehrkens JH, Obermeier A, Stepp H, Stummer W, Baumgartner R (2007) Interstitial photodynamic therapy of nonresectable malignant glioma recurrences using 5-aminolevulinic acid induced protoporphyrin IX. Lasers Surg Med 39(5):386–393CrossRefPubMed

Bilban M, Haschemi A, Wegiel B, Chin BY, Wagner O, Otterbein LE (2008) Heme oxygenase and carbon monoxide initiate homeostatic signaling. J Mol Med 86:267–279CrossRefPubMed

Cuadrado A, Rojo AI (2008) Heme oxygenase-1 as a therapeutic target in neurodegenerative diseases and brain infections. Curr Pharm Des 14:429–442CrossRefPubMed

Döring F, Walter J, Will J, Föcking M, Boll M, Amasheh S, Clauss W, Daniel H (1998) Delta-aminolevulinic acid transport by intestinal and renal peptide transporters and its physiological and clinical implications. J Clin Invest 101:2761–2767CrossRefPubMedPubMedCentral

el-Sharabasy MM, el-Waseef AM, Hafez MM, Salim SA (1992) Porphyrin metabolism in some malignant diseases. Br J Cancer 65:409–412CrossRefPubMedPubMedCentral

Ferreira GC, Franco R, Lloyd SG, Moura I, Moura JJ, Huynh BH (1995) Structure and function of ferrochelatase. J Bioenerg Biomembr 27:221–229CrossRefPubMed

Frank J, Lornejad-Schäfer MR, Schöffl H, Flaccus A, Lambert C, Biesalski HK (2007) Inhibition of heme oxygenase-1 increases responsiveness of melanoma cells to ALA-based photodynamic therapy. Int J Oncol 31:1539–1545PubMed

10.

Fukuda H, Batlle AM, Riley PA (1993) Kinetics of porphyrin accumulation in cultured epithelial cells exposed to ALA. Int J Biochem 25(10):1407–10CrossRefPubMed

11.

García SC, Moretti MB, Garay MV, Batlle A (1998) Delta-aminolevulinic acid transport through blood–brain barrier. Gen Pharmacol 31(4):579–582CrossRefPubMed

12.

Georgakoudi I, Keng PC, Foster TH (1999) Hypoxia significantly reduces aminolaevulinic acid-induced protoporphyrin IX synthesis in EMT6 cells. Br J Cancer 79(9–10):1372–7CrossRefPubMedPubMedCentral

13.

Gibson SL, Havens JJ, Metz L, Hilf R (2001) Is delta-aminolevulinic acid dehydratase rate-limiting in heme biosynthesis following exposure of cells to delta-aminolevulinic acid? Photochem Photobiol 73:312–317CrossRefPubMed

14.

Hilf R, Havens JJ, Gibson SL (1999) Effect of delta-aminolevulinic acid on protoporphyrin IX accumulation in tumor cells transfected with plasmids containing porphobilinogen deaminase DNA. Photochem Photobiol 70:334–340PubMed

15.

Inoue K, Karashima T, Kamada M, Shuin T, Kurabayashi A, Furihata M, Fujita H, Utsumi K, Sasaki J (2009) Regulation of 5-aminolevulinic acid-mediated protoporphyrin IX accumulation in human urothelial carcinomas. Pathobiology 76(6):303–314CrossRefPubMed

16.

Johansson A, Palte G, Schnell O, Tonn J-CC, Herms J, Stepp H (2010) 5-Aminolevulinic acid-induced protoporphyrin IX levels in tissue of human malignant brain tumors. Photochem Photobiol 86(6):1373–1378CrossRefPubMed

17.

Kennedy JC, Pottier RH (1992) Endogenous protoporphyrin IX, a clinically useful photosensitizer for photodynamic therapy. J Photochem Photobiol B 14(4):275–292CrossRefPubMed

18.

Kirkby KA, Adin CA (2006) Products of heme oxygenase and their potential therapeutic applications. Am J Physiol Ren Physiol 290:F563–71CrossRef

19.

Kowalczuk A, Macdonald RL, Amidei C, Dohrmann G, Erickson R, Hekmatpanah J, Krauss S, Krishnasamy S, Masters G, Mullan SF, Mundt AJ, Sweeney P, Vokes EE, Weir BKA, Wollman RL (1997) Quantitative imaging study of extent of surgical resection and prognosis of malignant astrocytomas. Neurosurgery 41(5):1028CrossRefPubMed

20.

Lacroix M, Abi-Said D, Fourney DR, Gokaslan ZL, Shi W, DeMonte F, Lang FF, McCutcheon IE, Hassenbusch SJ, Holland E, Hess K, Michael C, Miller D, Sawaya R (2001) A multivariate analysis of 416 patients with glioblastoma multiforme: prognosis, extent of resection, and survival. J Neurosurg 95(2):190–198CrossRefPubMed

21.

Miyake M, Ishii M, Kawashima K, Kodama T, Sugano K, Fujimoto K, Hirao Y (2009) siRNA-mediated knockdown of the heme synthesis and degradation pathways: modulation of treatment effect of 5-aminolevulinic acid-based photodynamic therapy in urothelial cancer cell lines. Photochem Photobiol 85:1020–1027CrossRefPubMed

22.

Moan J, Bech O, Gaullier JM, Stokke T, Steen HB, Ma LW, Berg K (1998) Protoporphyrin IX accumulation in cells treated with 5-aminolevulinic acid: dependence on cell density, cell size and cell cycle. Int J Cancer 75(1):134–9CrossRefPubMed

23.

Nicoll RA (1976) The interaction of porphyrin precursors with GABA receptors in the isolated frog spinal cord. Life Sci 19:521–525CrossRefPubMed

24.

Novotny A, Xiang J, Stummer W, Teuscher NS, Smith DE, Keep RF (2000) Mechanisms of 5-aminolevulinic acid uptake at the choroid plexus. J Neurochem 75:321–328CrossRefPubMed

25.

Ohgari Y, Nakayasu Y, Kitajima S, Sawamoto M, Mori H, Shimokawa O, Matsui H, Taketani S (2005) Mechanisms involved in delta-aminolevulinic acid (ALA)-induced photosensitivity of tumor cells: relation of ferrochelatase and uptake of ALA to the accumulation of protoporphyrin. Biochem Pharmacol 71:42–49CrossRefPubMed

26.

Otsuka S, Matsumoto K, Nakajima M, Tanaka T, Ogura S-I (2015) Oxygen availability for porphyrin biosynthesis enzymes determines the production of protoporphyrin IX (PpIX) during hypoxia. PLoS ONE 10(12), e0146026CrossRefPubMedPubMedCentral

27.

Piccirillo SGM, Dietz S, Madhu B, Griffiths J, Price SJ, Collins VP, Watts C (2012) Fluorescence-guided surgical sampling of glioblastoma identifies phenotypically distinct tumour-initiating cell populations in the tumour mass and margin. Br J Cancer 107(3):462–468CrossRefPubMedPubMedCentral

28.

Pichlmeier U, Bink A, Schackert G, Stummer W, Group ALAGS (2008) Resection and survival in glioblastoma multiforme: an RTOG recursive partitioning analysis of ALA study patients. Neuro Oncol 10(6):1025–1034CrossRefPubMedPubMedCentral

29.

Roberts DW, Valdés PA, Harris BT, Fontaine KM, Hartov A, Fan X, Ji S, Lollis SS, Pogue BW, Leblond F, Tosteson TD, Wilson BC, Paulsen KD (2011) Coregistered fluorescence-enhanced tumor resection of malignant glioma: relationships between δ-aminolevulinic acid-induced protoporphyrin IX fluorescence, magnetic resonance imaging enhancement, and neuropathological parameters. Clinical article. J Neurosurg 114(3):595–603CrossRefPubMed

30.

Rud E, Gederaas O, Høgset A, Berg K (2000) 5-aminolevulinic acid, but not 5-aminolevulinic acid esters, is transported into adenocarcinoma cells by system BETA transporters. Photochem Photobiol 71:640–647CrossRefPubMed

31.

Sanai N, Polley M-YY, McDermott MW, Parsa AT, Berger MS (2011) An extent of resection threshold for newly diagnosed glioblastomas. J Neurosurg 115(1):3–8CrossRefPubMed

32.

Sanai N, Snyder LA, Honea NJ, Coons SW, Eschbacher JM, Smith KA, Spetzler RF (2011) Intraoperative confocal microscopy in the visualization of 5-aminolevulinic acid fluorescence in low-grade gliomas. J Neurosurg 115(4):740–8CrossRefPubMed

33.

Sasaki K, Watanabe M, Tanaka T (2002) Biosynthesis, biotechnological production and applications of 5-aminolevulinic acid. Appl Microbiol Biotechnol 58(1):23–29CrossRefPubMed

34.

Schipper HM, Song W, Zukor H, Hascalovici JR, Zeligman D (2009) Heme oxygenase-1 and neurodegeneration: expanding frontiers of engagement. J Neurochem 110:469–485CrossRefPubMed

35.

Schoenfeld N, Epstein O, Lahav M, Mamet R, Shaklai M, Atsmon A (1988) The heme biosynthetic pathway in lymphocytes of patients with malignant lymphoproliferative disorders. Cancer Lett 43:43–48CrossRefPubMed

36.

Shen H, Smith DE, Keep RF, Brosius FC (2004) Immunolocalization of the proton-coupled oligopeptide transporter PEPT2 in developing rat brain. Mol Pharm 1:248–256CrossRefPubMed

37.

Sinha AK, Anand S, Ortel BJ, Chang Y, Mai Z, Hasan T, Maytin EV (2006) Methotrexate used in combination with aminolaevulinic acid for photodynamic killing of prostate cancer cells. Br J Cancer 95(4):485–95CrossRefPubMedPubMedCentral

38.

Stepp H, Beck T, Pongratz T, Meinel T, Kreth F-WW, Tonn JCC, Stummer W (2007) ALA and malignant glioma: fluorescence-guided resection and photodynamic treatment. J Env Pathol Toxicol Oncol 26(2):157–164CrossRef

39.

Stewart DJ (1994) A critique of the role of the blood–brain barrier in the chemotherapy of human brain tumors. J Neurooncol 20:121–139CrossRefPubMed

40.

Stummer W, Van Den Bent MJ, Westphal M (2011) Cytoreductive surgery of glioblastoma as the key to successful adjuvant therapies: new arguments in an old discussion. Acta Neurochir (Wien) 153(6):1211–1218CrossRef

41.

Stummer W, Meinel T, Ewelt C, Martus P, Jakobs O, Felsberg J, Reifenberger G (2012) Prospective cohort study of radiotherapy with concomitant and adjuvant temozolomide chemotherapy for glioblastoma patients with no or minimal residual enhancing tumor load after surgery. J Neurooncol 108(1):89–97CrossRefPubMedPubMedCentral

42.

Stummer W, Novotny A, Stepp H, Goetz C, Bise K, Reulen HJ (2000) Fluorescence-guided resection of glioblastoma multiforme by using 5-aminolevulinic acid-induced porphyrins: a prospective study in 52 consecutive patients. J Neurosurg 93(6):1003–1013CrossRefPubMed

43.

Stummer W, Pichlmeier U, Meinel T, Wiestler OD, Zanella F, Reulen HJ, Group A-GS, Study A (2006) Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial. Lancet Oncol 7(5):392–401CrossRefPubMed

44.

Stummer W, Reulen HJ, Meinel T, Pichlmeier U, Schumacher W, Tonn JC, Rohde V, Oppel F, Turowski B, Woiceiechowsky C, Franz K, Pietsch T, ALA-Glioma Study Group (2008) Extent of resection and survival in glioblastoma multiforme: identification of and adjustment for bias. Neurosurgery 62(3):564–576CrossRefPubMed

45.

Stummer W, Stocker S, Novotny A, Heimann A, Sauer O, Kempski O, Plesnila N, Wietzorrek J, Reulen HJ (1998) In vitro and in vivo porphyrin accumulation by C6 glioma cells after exposure to 5-aminolevulinic acid. J Photochem Photobiol B 45(2–3):160–169CrossRefPubMed

46.

Stummer W, Tonn J-C, Goetz C, Ullrich W, Stepp H, Bink A, Pietsch T, Pichlmeier U (2014) 5-Aminolevulinic acid-derived tumor fluorescence: the diagnostic accuracy of visible fluorescence qualities as corroborated by spectrometry and histology and postoperative imaging. Neurosurgery 74(3):310–9, discussion 319–20CrossRefPubMed

47.

Teng L, Nakada M, Zhao SG, Endo Y, Furuyama N, Nambu E, Pyko IV, Hayashi Y, Hamada J-II (2011) Silencing of ferrochelatase enhances 5-aminolevulinic acid-based fluorescence and photodynamic therapy efficacy. Br J Cancer 104(5):798–807CrossRefPubMedPubMedCentral

48.

Terr L, Weiner LP (1983) An autoradiographic study of delta-aminolevulinic acid uptake by mouse brain. Exp Neurol 79(2):564–568CrossRefPubMed

49.

Valdés PA, Kim A, Brantsch M, Niu C, Moses ZB, Tosteson TD, Wilson BC, Paulsen KD, Roberts DW, Harris BT (2011) δ-aminolevulinic acid-induced protoporphyrin IX concentration correlates with histopathologic markers of malignancy in human gliomas: the need for quantitative fluorescence-guided resection to identify regions of increasing malignancy. Neuro Oncol 13(8):846–56CrossRefPubMedPubMedCentral

50.

Valdés PA, Leblond F, Kim A, Harris B, Wilson B, Fan X, Tosteson T, Hartov A, Ji S, Erkmen K, Simmons NE, Paulsen K, Roberts DW (2011) Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker. J Neurosurg 115:11–17CrossRefPubMedPubMedCentral

51.

Valdés PA, Samkoe K, O’Hara JA, Roberts DW, Paulsen KD, Pogue BW (2010) Deferoxamine iron chelation increases delta-aminolevulinic acid induced protoporphyrin IX in xenograft glioma model. Photochem Photobiol 86(2):471–475CrossRefPubMed

52.

Vecht CJ, Avezaat CJ, van Putten WL, Eijkenboom WM, Stefanko SZ (1990) The influence of the extent of surgery on the neurological function and survival in malignant glioma. A retrospective analysis in 243 patients. J Neurol Neurosurg Psychiatry 53(6):466–471CrossRefPubMedPubMedCentral

53.

Vogelbaum MA, Jost S, Aghi MK, Heimberger AB, Sampson JH, Wen PY, Macdonald DR, Van den Bent MJ, Chang SM (2012) Application of novel response/progression measures for surgically delivered therapies for gliomas: Response Assessment in Neuro-Oncology (RANO) Working Group. Neurosurgery 70(1):234–43, discussion 243–4CrossRefPubMed

54.

Weissleder R, Pittet MJ (2008) Imaging in the era of molecular oncology. Nature 452(7187):580–589CrossRefPubMedPubMedCentral

55.

Widhalm G, Wolfsberger S, Minchev G, Woehrer A, Krssak M, Czech T, Prayer D, Asenbaum S, Hainfellner JA, Knosp E (2010) 5-Aminolevulinic acid is a promising marker for detection of anaplastic foci in diffusely infiltrating gliomas with nonsignificant contrast enhancement. Cancer 116(6):1545–1552CrossRefPubMed

56.

Xiang J, Hu Y, Smith DE, Keep RF (2006) PEPT2-mediated transport of 5-aminolevulinic acid and carnosine in astrocytes. Brain Res 1122:18–23CrossRefPubMedPubMedCentral

57.

Yamamoto F, Ohgari Y, Yamaki N, Kitajima S, Shimokawa O, Matsui H, Taketani S (2007) The role of nitric oxide in delta-aminolevulinic acid (ALA)-induced photosensitivity of cancerous cells. Biochem Biophys Res Commun 353:541–546CrossRefPubMed

58.

Yang D-F, Lee J-W, Chen H-M, Huang Z, Hsu Y-C (2014) Methotrexate enhances 5-aminolevulinic acid-mediated photodynamic therapy-induced killing of human SCC4 cells by upregulation of coproporphyrinogen oxidase. J Formos Med Assoc 113(2):88–93CrossRefPubMed

Titel: Selective 5-aminolevulinic acid-induced protoporphyrin IX fluorescence in Gliomas
verfasst von: Ruichong Ma
Colin Watts
Publikationsdatum: 06.08.2016
Verlag: Springer Vienna
Erschienen in: Acta Neurochirurgica / Ausgabe 10/2016
Print ISSN: 0001-6268
Elektronische ISSN: 0942-0940
DOI: https://doi.org/10.1007/s00701-016-2897-y

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Neurologie

23.04.2024 | Demenz | Nachrichten

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Selective 5-aminolevulinic acid-induced protoporphyrin IX fluorescence in Gliomas

Abstract

Leitlinien kompakt für die Neurologie

Neu im Fachgebiet Neurologie

Demenzkranke durch Antipsychotika vielfach gefährdet

Parkinson-Therapie im Wandel – aktuelle Leitlinie im Fokus

Auf diese Krankheiten bei Geflüchteten sollten Sie vorbereitet sein

Hustenstiller lindert Agitation bei Alzheimer

Update Neurologie

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 10/2016

Pyogenic ventriculitis and the ‘lodge sign’

Sequential antimicrobial treatment with linezolid for neurosurgical infections: efficacy, safety and cost study

Flexible endoscope-assisted evacuation of chronic subdural hematomas

Grading of moyamoya disease allows stratification for postoperative ischemia in bilateral revascularization surgery

Does pain relief by CT-guided indirect cervical nerve root injection with local anesthetics and steroids predict pain relief after decompression surgery for cervical nerve root compression?

Dementia resulting from expansion of basilar artery aneurysm: two case reports and a review of the literature

Leitlinien kompakt für die Neurologie

Neu im Fachgebiet Neurologie

Demenzkranke durch Antipsychotika vielfach gefährdet

Parkinson-Therapie im Wandel – aktuelle Leitlinie im Fokus

Auf diese Krankheiten bei Geflüchteten sollten Sie vorbereitet sein

Hustenstiller lindert Agitation bei Alzheimer

Update Neurologie