Introduction
Study design
Outcome measures
Antibiotic resistance
Other considerations
Future studies
Study | Year | Institute | Patients | Design | Primary objective | Intervention | Study status |
---|---|---|---|---|---|---|---|
Microbiologic effect of selective decontamination of the digestive tract with colistin, gentamicin, and nystatin | 2007 | University of Pittsburgh Pennsylvania | 40 | Observational | Effect of SDD on vancomycin-resistant enterococci colonization | SDD (colistin, gentamicin, nystatin) | Not started, terminated |
Selective digestive decontamination in carriers of carbapenem-resistant Klebsiella pneumoniae
| 2008 | Soroka University Medical Center, Israel |
Unknown
| Blinded RCT | Effect of SDD on carbapenem-resistant Klebsiella
| SDD (gentamicin and polymyxin E) | Completed |
The effects of SDD and SOD on antibiotic resistance in the ICU | 2009 | University Medical Center Utrecht, Utrecht, The Netherlands | 10,000 | Randomized crossover multicenter trial | Effect of SDD and SDD on antimicrobial resistance | SDD and SOD (amphotericin B, tobramycin, colistin, and cefotaxim in SDD) | Running |
Resistant Gram-negative bacteria after cessation of SDD or SOD in ICU patients | 2010 | Leiden University Medical Center, Leiden, The Netherlands | 1,200 | Prospective observational multicenter trial | Rectal colonization with any resistant aerobic Gram-negative bacteria at any time point within 10 days after ICU discharge | SDD and SOD (amphotericin B, tobramycin, colistin, and cefotaxim in SDD) | Running |
R-GNOSIS: Decolonization strategies in intensive care | 2011 | University Medical Center Utrecht, Utrecht, The Netherlands | 10,400 | Randomized crossover multicenter trial | Effect of SDD, SOD, and chlorhexidine mouthwash on Gram-negative bacteremia rate | SDD and SOD (amphotericin B, tobramycin, colistin) and chlorhexidine 2% | Prior to participant recruitment |