Background
Methods
Study sample
Demographics
Outcome ascertainment
Statistical analysis
Mean ± S.D. [range] | Entire study sample | No exercise | Any exercise |
Pvalue |
---|---|---|---|---|
n
| 1038 | 264 | 774 | - |
Sex (% male) | 51.8 | 47.0 | 53.5 | 0.07 |
Race/Ethnicity (% non-white) | 9.2 | 11.0 | 8.5 | 0.23 |
(n = 1036) | (n = 263) | (n = 773) | ||
Age at Diagnosis (years) | 2.5 ± 5.7 | 1.5 ± 4.7 | 2.8 ± 6.0 | 0.002 |
[0, 52] | [0, 51] | [0, 52] | ||
(n = 1025) | (n = 259) | (n = 766) | ||
CFTR Genotype (% F508del homozygotes) | 45.2 | 46.4 | 44.7 | 0.64 |
(n = 1023) | (n = 263) | (n = 760) | ||
Exocrine Pancreatic Function (% insufficient) | 83.3 | 85.9 | 82.4 | 0.19 |
(n = 1017) | (n =256) | (n = 761) | ||
Age at Ascertainment of Exercise Status (years) | 13.8 ± 10.2 | 10.1 ± 11.1 | 15.0 ± 9.6 | <0.001 |
[0.1, 61.3] | [0.1, 61.3] | [1.4, 57.8] | ||
Wheezing Reported with Exercise (% yes) | 23.4 | 22.0 | 23.9 | 0.54 |
(n = 995) | (n = 250) | (n = 745) | ||
Baseline FEV
1
% Predicted
†
| 84.5 ± 22.5 | 78.0 ± 26.7 | 85.6 ± 21.5 | 0.001 |
[19.7, 145.8] | [19.7, 145.8] | [21.4, 137.6] | ||
(n = 766) | (n = 115) | (n = 651) | ||
Change in FEV
1
% Predicted/Year
††
| -1.33 ± 4.65 | -0.99 ± 5.48 | -1.39 ± 4.47 | 0.44 |
[-26.4, 24.3] | [-26.4, 23.4] | [-23.2, 24.3] | ||
(n = 558) | (n = 94) | (n = 464) | ||
Baseline BMI Z-score
†
| -0.15 ± 0.99 | -0.12 ± 1.05 | -0.16 ± 0.98 | 0.55 |
[-4.72, 3.12] | [-4.06, 3.12] | [-4.72, 2.50] | ||
(n = 904) | (n = 207) | (n = 697) | ||
Change in BMI Z-score/Year
††
| -0.01 ± 0.20 | 0.02 ± 0.23 | -0.01 ± 0.19 | 0.16 |
[-1.02, 0.83] | [-1.02, 0.70] | [-0.82, 0.83] | ||
(n = 591) | (n = 134) | (n = 457) |
Results
Demographics
Respiratory outcomes
Models: n = 389 subjects | Estimated FEV1% at time = 0 without exercise* | Estimated FEV1% at time = 0 with exercise* (pvalue) | Baseline Change in FEV1% per year (pvalue) | Change in FEV1% over baseline per year with exercise (pvalue) | Change in FEV1% over baseline per year for interaction (pvalue) | |
---|---|---|---|---|---|---|
Any Exercise
|
Unadjusted Model (No Covariates)
| 74.8 | 82.6 (0.020) | -2.01 (0.001) | 0.28 (0.67) | - |
Adjusted Model
| 81.7 | 81.6 (0.95) | -2.03 (0.001) | 0.35 (0.59) | - | |
Adjusted Model + Interaction for Sex
| 81.9 | 81.8 (0.92) | -2.03 (0.001) | 0.05 (0.94) | 0.67 (0.17) | |
Adjusted Model + Interaction for Age
| 82.2 | 82.1 (0.93) | -2.03 (0.001) | -0.45 (0.50) | 1.98 (<0.001) | |
Adjusted Model + Interaction for Baseline FEV
1
| 81.6 | 81.4 (0.87) | -2.03 (0.001) | -0.10 (0.88) | 1.08 (0.028) | |
Competitive Exercise
|
Unadjusted Model (No Covariates)
| 77.9 | 85.7 (0.001) | -1.70 (<0.001) | -0.16 (0.74) | - |
Adjusted Model
| 81.7 | 81.6 (0.98) | -1.64 (<0.001) | -0.18 (0.70) | - | |
Adjusted Model + Interaction for Sex
| 81.7 | 81.7 (0.98) | -1.64 (<0.001) | -0.28 (0.61) | 0.22 (0.73) | |
Adjusted Model + Interaction for Age
| 81.1 | 81.1 (0.93) | -1.64 (<0.001) | -0.84 (0.11) | 1.83 (0.004) | |
Adjusted Model + Interaction for Baseline FEV
1
| 81.7 | 81.6 (0.93) | -1.65 (<0.001) | -0.49 (0.35) | 0.87 (0.17) |
Nutritional outcomes
Models: n = 366 subjects | Estimated BMI Z-score at time = 0 without exercise* | Estimated BMI Z-score at time = 0 with exercise*(pvalue) | Baseline decline in BMI Z-score per year (pvalue) | Change in BMI Z-score over baseline per year with exercise (pvalue) | Change in BMI Z-score over baseline per year for interaction (pvalue) | |
---|---|---|---|---|---|---|
Any Exercise
|
Unadjusted Model (No Covariates)
| -0.36 | -0.30 (0.65) | -0.05 (0.08) | 0.03 (0.29) | - |
Adjusted Model
| -0.30 | -0.30 (0.96) | -0.05 (0.08) | 0.03 (0.30) | - | |
Adjusted Model + Interaction for Sex
| -0.29 | -0.30 (0.93) | -0.05 (0.08) | 0.02 (0.48) | 0.02 (0.36) | |
Adjusted Model + Interaction for Age
| -0.32 | -0.32 (0.91) | -0.05 (0.08) | 0.001 (0.98) | 0.08 (0.001) | |
Adjusted Model + Interaction for Baseline BMI Z-Score
| -0.24 | -0.25 (0.92) | -0.05 (0.08) | 0.03 (0.92) | 0.04 (0.07) | |
Competitive Exercise
|
Unadjusted Model (No Covariates)
| -0.41 | -0.18 (0.021) | -0.03 (0.025) | 0.02 (0.27) | - |
Adjusted Model
| -0.30 | -0.31 (0.72) | -0.03 (0.024) | 0.03 (0.25) | - | |
Adjusted Model + Interaction for Sex
| -0.30 | -0.31 (0.72) | -0.03 (0.024) | 0.02 (0.38) | 0.01 (0.80) | |
Adjusted Model + Interaction for Age
| -0.30 | -0.31 (0.69) | -0.03 (0.024) | 0.005 (0.85) | 0.06 (0.06) | |
Adjusted Model + Interaction for Baseline BMI Z-Score
| -0.24 | -0.26 (0.67) | -0.03 (0.023) | -0.01 (0.68) | 0.06 (0.044) |