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07.12.2022 | Sleep Breathing Physiology and Disorders • Original Article

Self-reported sleep quality and oligo/astheno/teratozoospermia among men attending an infertility clinic: a longitudinal study

verfasst von: Xue-Fen Cai, Jian-Ming Zhao, Yi-Song Yang, Cai-Yun Wang, Mei-Xin Nian, Jie-Feng Huang, Bi-Ying Wang

Erschienen in: Sleep and Breathing

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Abstract

Objective

We aimed to examine the influence of sleep disturbances on the risk of oligo/astheno/teratozoospermia (OAT) in men attending an infertility clinic.

Methods

We consecutively enrolled men attending an infertility clinic from July 2020 to June 2021. Semen parameters were obtained at initial presentation, and the Pittsburgh Sleep Quality Index, Epworth Sleepiness Scale score, and the STOP-BANG Questionnair were completed to assess sleep quality. Embryo outcomes were evaluated after infertility treatment.

Results

Of 466 men enrolled, 119 had OAT (OAT group) and 347 had normozoospermia (NS group). There were no differences between the two groups regarding Epworth Sleepiness Scale and STOP-BANG Questionnaire scores. The prevalence of poor sleep quality (Pittsburgh Sleep Quality Index score ≥ 5) in the OAT group was significantly higher than that in the NS group (42% vs. 29%, p = 0.009). A higher rate of poor subjective sleep quality was observed in the OAT group compared with the NS group (p = 0.005) and Pearson’s correlations revealed a negative relationship between subjective sleep quality and semen quality. Logistic regression found that subjective sleep quality was independently associated with an increased risk of OAT (adjusted odds ratio = 0.610, p = 0.007).

Conclusions

Men with OAT attending an infertility clinic exhibited poor subjective sleep quality. Improving sleep disturbances may be a target intervention to reduce the risk of OAT. This possibility warrants further investigation.
Literatur
1.
Zurück zum Zitat Thorpy MJ (2012) Classification of sleep disorders. Neurotherapeutics 9(4):687–701 CrossRef Thorpy MJ (2012) Classification of sleep disorders. Neurotherapeutics 9(4):687–701 CrossRef
2.
Zurück zum Zitat Huang ST, Lin CL, Yu TM, Yang TC, Kao CH (2015) Nonapnea sleep disorders and incident chronic kidney disease: a population-based retrospective cohort study. Medicine (Baltimore) 94(4):e429 CrossRef Huang ST, Lin CL, Yu TM, Yang TC, Kao CH (2015) Nonapnea sleep disorders and incident chronic kidney disease: a population-based retrospective cohort study. Medicine (Baltimore) 94(4):e429 CrossRef
3.
Zurück zum Zitat Hung HM, Chen CH (2011) Using alternative therapies in treating sleep dis- turbance. Hu Li Za Zhi 58(1):73–78 Hung HM, Chen CH (2011) Using alternative therapies in treating sleep dis- turbance. Hu Li Za Zhi 58(1):73–78
4.
Zurück zum Zitat Benjafield AV, Ayas NT, Eastwood PR, Heinzer R, Ip MSM, Morrell MJ, Nunez CM, Patel SR, Penzel T, Pepin JL et al (2019) Estimation of the global prevalence and burden of obstructive sleep apnoea: a literature-based analysis. Lancet Respir Med 7(8):687–698 CrossRef Benjafield AV, Ayas NT, Eastwood PR, Heinzer R, Ip MSM, Morrell MJ, Nunez CM, Patel SR, Penzel T, Pepin JL et al (2019) Estimation of the global prevalence and burden of obstructive sleep apnoea: a literature-based analysis. Lancet Respir Med 7(8):687–698 CrossRef
5.
Zurück zum Zitat Ohayon MM (2002) Epidemiology of insomnia: what we know and what we still need to learn. Sleep Med Rev 6(2):97–111 CrossRef Ohayon MM (2002) Epidemiology of insomnia: what we know and what we still need to learn. Sleep Med Rev 6(2):97–111 CrossRef
6.
Zurück zum Zitat Nagai M, Hoshide S, Kario K (2010) Sleep duration as a risk factor for cardiovascular disease- a review of the recent literature. Curr Cardiol Rev 6(1):54–61 CrossRef Nagai M, Hoshide S, Kario K (2010) Sleep duration as a risk factor for cardiovascular disease- a review of the recent literature. Curr Cardiol Rev 6(1):54–61 CrossRef
7.
Zurück zum Zitat Cappuccio FP, D’Elia L, Strazzullo P, Miller MA (2010) Quantity and quality of sleep and incidence of type 2 diabetes: a systematic review and meta-analysis. Diabetes Care 33(2):414–420 CrossRef Cappuccio FP, D’Elia L, Strazzullo P, Miller MA (2010) Quantity and quality of sleep and incidence of type 2 diabetes: a systematic review and meta-analysis. Diabetes Care 33(2):414–420 CrossRef
8.
Zurück zum Zitat Romero-Corral A, Caples SM, Lopez-Jimenez F, Somers VK (2010) Interactions between obesity and obstructive sleep apnea: implications for treatment. Chest 137(3):711–719 CrossRef Romero-Corral A, Caples SM, Lopez-Jimenez F, Somers VK (2010) Interactions between obesity and obstructive sleep apnea: implications for treatment. Chest 137(3):711–719 CrossRef
9.
Zurück zum Zitat Wang ID, Liu YL, Peng CK, Chung CH, Chang SY, Tsao CH, Chien Ph DW (2018) Non-apnea sleep disorder increases the risk of subsequent female infertility-a nationwide population-based cohort study. Sleep 41(1) Wang ID, Liu YL, Peng CK, Chung CH, Chang SY, Tsao CH, Chien Ph DW (2018) Non-apnea sleep disorder increases the risk of subsequent female infertility-a nationwide population-based cohort study. Sleep 41(1)
10.
Zurück zum Zitat Palnitkar G, Phillips CL, Hoyos CM, Marren AJ, Bowman MC, Yee BJ (2018) Linking sleep disturbance to idiopathic male infertility. Sleep Med Rev 42:149–159 CrossRef Palnitkar G, Phillips CL, Hoyos CM, Marren AJ, Bowman MC, Yee BJ (2018) Linking sleep disturbance to idiopathic male infertility. Sleep Med Rev 42:149–159 CrossRef
11.
Zurück zum Zitat Ombelet W, Cooke I, Dyer S, Serour G, Devroey P (2008) Infertility and the provision of infertility medical services in developing countries. Hum Reprod Update 14(6):605–621 CrossRef Ombelet W, Cooke I, Dyer S, Serour G, Devroey P (2008) Infertility and the provision of infertility medical services in developing countries. Hum Reprod Update 14(6):605–621 CrossRef
12.
Zurück zum Zitat Agarwal A, Mulgund A, Hamada A, Chyatte MR (2015) A unique view on male infertility around the globe. Reprod Biol Endocrinol 13:37 CrossRef Agarwal A, Mulgund A, Hamada A, Chyatte MR (2015) A unique view on male infertility around the globe. Reprod Biol Endocrinol 13:37 CrossRef
13.
Zurück zum Zitat Jensen TK, Andersson AM, Skakkebaek NE, Joensen UN, Blomberg Jensen M, Lassen TH, Nordkap L, Olesen IA, Hansen AM, Rod NH et al (2013) Association of sleep disturbances with reduced semen quality: a cross-sectional study among 953 healthy young Danish men. Am J Epidemiol 177(10):1027–1037 CrossRef Jensen TK, Andersson AM, Skakkebaek NE, Joensen UN, Blomberg Jensen M, Lassen TH, Nordkap L, Olesen IA, Hansen AM, Rod NH et al (2013) Association of sleep disturbances with reduced semen quality: a cross-sectional study among 953 healthy young Danish men. Am J Epidemiol 177(10):1027–1037 CrossRef
14.
Zurück zum Zitat Du CQ, Yang YY, Chen J, Feng L, Lin WQ (2020) Association between sleep quality and semen parameters and reproductive hormones: a cross-sectional study in Zhejiang, China. Nat Sci Sleep 12:11–18 CrossRef Du CQ, Yang YY, Chen J, Feng L, Lin WQ (2020) Association between sleep quality and semen parameters and reproductive hormones: a cross-sectional study in Zhejiang, China. Nat Sci Sleep 12:11–18 CrossRef
15.
Zurück zum Zitat Buysse DJ, Reynolds CF 3rd, Monk TH, Berman SR, Kupfer DJ (1989) The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res 28(2):193–213 CrossRef Buysse DJ, Reynolds CF 3rd, Monk TH, Berman SR, Kupfer DJ (1989) The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res 28(2):193–213 CrossRef
16.
Zurück zum Zitat Johns MW (1991) A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep 14(6):540–545 CrossRef Johns MW (1991) A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep 14(6):540–545 CrossRef
17.
Zurück zum Zitat Chung F, Abdullah HR, Liao P (2016) STOP-Bang Questionnaire: a practical approach to screen for obstructive sleep apnea. Chest 149(3):631–638 CrossRef Chung F, Abdullah HR, Liao P (2016) STOP-Bang Questionnaire: a practical approach to screen for obstructive sleep apnea. Chest 149(3):631–638 CrossRef
18.
Zurück zum Zitat Lu JC, Huang YF, Lu NQ (2010) WHO Laboratory Manual for the Examination and Processing of Human Semen: its applicability to andrology laboratories in China. Zhonghua Nan Ke Xue 16(10):867–871 Lu JC, Huang YF, Lu NQ (2010) WHO Laboratory Manual for the Examination and Processing of Human Semen: its applicability to andrology laboratories in China. Zhonghua Nan Ke Xue 16(10):867–871
19.
Zurück zum Zitat Alpha Scientists in Reproductive M, Embryology ESIGo (2011) The Istanbul consensus workshop on embryo assessment: proceedings of an expert meeting. Hum Reprod 26(6):1270–1283 CrossRef Alpha Scientists in Reproductive M, Embryology ESIGo (2011) The Istanbul consensus workshop on embryo assessment: proceedings of an expert meeting. Hum Reprod 26(6):1270–1283 CrossRef
20.
Zurück zum Zitat Gardner DK, Lane M, Stevens J, Schlenker T, Schoolcraft WB (2000) Blastocyst score affects implantation and pregnancy outcome: towards a single blastocyst transfer. Fertil Steril 73(6):1155–1158 CrossRef Gardner DK, Lane M, Stevens J, Schlenker T, Schoolcraft WB (2000) Blastocyst score affects implantation and pregnancy outcome: towards a single blastocyst transfer. Fertil Steril 73(6):1155–1158 CrossRef
21.
Zurück zum Zitat Buysse DJ, Hall ML, Strollo PJ, Kamarck TW, Owens J, Lee L, Reis SE, Matthews KA (2008) Relationships between the Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS), and clinical/polysomnographic measures in a community sample. J Clin Sleep Med 4(6):563–571 CrossRef Buysse DJ, Hall ML, Strollo PJ, Kamarck TW, Owens J, Lee L, Reis SE, Matthews KA (2008) Relationships between the Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS), and clinical/polysomnographic measures in a community sample. J Clin Sleep Med 4(6):563–571 CrossRef
22.
Zurück zum Zitat Chen HG, Sun B, Chen YJ, Chavarro JE, Hu SH, Xiong CL, Pan A, Meng TQ, Wang YX, Messerlian C (2020) Sleep duration and quality in relation to semen quality in healthy men screened as potential sperm donors. Environ Int 135:105368 CrossRef Chen HG, Sun B, Chen YJ, Chavarro JE, Hu SH, Xiong CL, Pan A, Meng TQ, Wang YX, Messerlian C (2020) Sleep duration and quality in relation to semen quality in healthy men screened as potential sperm donors. Environ Int 135:105368 CrossRef
23.
Zurück zum Zitat Hvidt JEM, Knudsen UB, Zachariae R, Ingerslev HJ, Philipsen MT, Frederiksen Y (2020) Associations of bedtime, sleep duration, and sleep quality with semen quality in males seeking fertility treatment: a preliminary study. Basic Clin Androl 30:5 CrossRef Hvidt JEM, Knudsen UB, Zachariae R, Ingerslev HJ, Philipsen MT, Frederiksen Y (2020) Associations of bedtime, sleep duration, and sleep quality with semen quality in males seeking fertility treatment: a preliminary study. Basic Clin Androl 30:5 CrossRef
24.
Zurück zum Zitat Chen Q, Yang H, Zhou N, Sun L, Bao H, Tan L, Chen H, Ling X, Zhang G, Huang L et al (2016) Inverse U-shaped association between sleep duration and semen quality: longitudinal observational study (MARHCS) in Chongqing, China. Sleep 39(1):79–86 CrossRef Chen Q, Yang H, Zhou N, Sun L, Bao H, Tan L, Chen H, Ling X, Zhang G, Huang L et al (2016) Inverse U-shaped association between sleep duration and semen quality: longitudinal observational study (MARHCS) in Chongqing, China. Sleep 39(1):79–86 CrossRef
25.
Zurück zum Zitat Caetano G, Bozinovic I, Dupont C, Leger D, Levy R, Sermondade N (2021) Impact of sleep on female and male reproductive functions: a systematic review. Fertil Steril 115(3):715–731 CrossRef Caetano G, Bozinovic I, Dupont C, Leger D, Levy R, Sermondade N (2021) Impact of sleep on female and male reproductive functions: a systematic review. Fertil Steril 115(3):715–731 CrossRef
26.
Zurück zum Zitat Zhao L, Pang A (2020) Effects of Metabolic syndrome on semen quality and circulating sex hormones: a systematic review and meta-analysis. Front Endocrinol (Lausanne) 11:428 CrossRef Zhao L, Pang A (2020) Effects of Metabolic syndrome on semen quality and circulating sex hormones: a systematic review and meta-analysis. Front Endocrinol (Lausanne) 11:428 CrossRef
27.
Zurück zum Zitat Oztekin U, Hacimusalar Y, Gurel A, Karaaslan O (2020) The relationship of male infertility with somatosensory amplification, health anxiety and depression levels. Psychiatry Investig 17(4):350–355 CrossRef Oztekin U, Hacimusalar Y, Gurel A, Karaaslan O (2020) The relationship of male infertility with somatosensory amplification, health anxiety and depression levels. Psychiatry Investig 17(4):350–355 CrossRef
28.
Zurück zum Zitat Hu GX, Lian QQ, Lin H, Latif SA, Morris DJ, Hardy MP, Ge RS (2008) Rapid mechanisms of glucocorticoid signaling in the Leydig cell. Steroids 73(9–10):1018–1024 CrossRef Hu GX, Lian QQ, Lin H, Latif SA, Morris DJ, Hardy MP, Ge RS (2008) Rapid mechanisms of glucocorticoid signaling in the Leydig cell. Steroids 73(9–10):1018–1024 CrossRef
29.
Zurück zum Zitat Martin LJ, Tremblay JJ (2008) Glucocorticoids antagonize cAMP-induced Star transcription in Leydig cells through the orphan nuclear receptor NR4A1. J Mol Endocrinol 41(3):165–175 CrossRef Martin LJ, Tremblay JJ (2008) Glucocorticoids antagonize cAMP-induced Star transcription in Leydig cells through the orphan nuclear receptor NR4A1. J Mol Endocrinol 41(3):165–175 CrossRef
30.
Zurück zum Zitat Vigano P, Chiaffarino F, Bonzi V, Salonia A, Ricci E, Papaleo E, Mauri PA, Parazzini F (2017) Sleep disturbances and semen quality in an Italian cross sectional study. Basic Clin Androl 27:16 CrossRef Vigano P, Chiaffarino F, Bonzi V, Salonia A, Ricci E, Papaleo E, Mauri PA, Parazzini F (2017) Sleep disturbances and semen quality in an Italian cross sectional study. Basic Clin Androl 27:16 CrossRef
31.
Zurück zum Zitat Liu MM, Liu L, Chen L, Yin XJ, Liu H, Zhang YH, Li PL, Wang S, Li XX, Yu CH (2017) Sleep deprivation and late bedtime impair sperm health through increasing antisperm antibody production: a prospective study of 981 healthy men. Med Sci Monit 23:1842–1848 CrossRef Liu MM, Liu L, Chen L, Yin XJ, Liu H, Zhang YH, Li PL, Wang S, Li XX, Yu CH (2017) Sleep deprivation and late bedtime impair sperm health through increasing antisperm antibody production: a prospective study of 981 healthy men. Med Sci Monit 23:1842–1848 CrossRef
32.
Zurück zum Zitat Demirkol MK, Yildirim A, Gica S, Dogan NT, Resim S (2021) Evaluation of the effect of shift working and sleep quality on semen parameters in men attending infertility clinic. Andrologia 53(8):e14116 CrossRef Demirkol MK, Yildirim A, Gica S, Dogan NT, Resim S (2021) Evaluation of the effect of shift working and sleep quality on semen parameters in men attending infertility clinic. Andrologia 53(8):e14116 CrossRef
33.
Zurück zum Zitat Aitken RJ, Jones KT, Robertson SA (2012) Reactive oxygen species and sperm function–in sickness and in health. J Androl 33(6):1096–1106 CrossRef Aitken RJ, Jones KT, Robertson SA (2012) Reactive oxygen species and sperm function–in sickness and in health. J Androl 33(6):1096–1106 CrossRef
34.
Zurück zum Zitat Li Z, Zhou Y, Liu R, Lin H, Liu W, Xiao W, Lin Q (2012) Effects of semen processing on the generation of reactive oxygen species and mitochondrial membrane potential of human spermatozoa. Andrologia 44(3):157–163 CrossRef Li Z, Zhou Y, Liu R, Lin H, Liu W, Xiao W, Lin Q (2012) Effects of semen processing on the generation of reactive oxygen species and mitochondrial membrane potential of human spermatozoa. Andrologia 44(3):157–163 CrossRef
35.
Zurück zum Zitat Torres M, Laguna-Barraza R, Dalmases M, Calle A, Pericuesta E, Montserrat JM, Navajas D, Gutierrez-Adan A, Farre R (2014) Male fertility is reduced by chronic intermittent hypoxia mimicking sleep apnea in mice. Sleep 37(11):1757–1765 CrossRef Torres M, Laguna-Barraza R, Dalmases M, Calle A, Pericuesta E, Montserrat JM, Navajas D, Gutierrez-Adan A, Farre R (2014) Male fertility is reduced by chronic intermittent hypoxia mimicking sleep apnea in mice. Sleep 37(11):1757–1765 CrossRef
36.
Zurück zum Zitat Wang J, Gong X, Meng F, Deng S, Dai H, Bao B, Feng J, Li H, Wang B (2020) Biological network model of effect of chronic intermittent hypoxia on spermatogenesis in rats. Med Sci Monit 26:e925579 Wang J, Gong X, Meng F, Deng S, Dai H, Bao B, Feng J, Li H, Wang B (2020) Biological network model of effect of chronic intermittent hypoxia on spermatogenesis in rats. Med Sci Monit 26:e925579
Metadaten
Titel
Self-reported sleep quality and oligo/astheno/teratozoospermia among men attending an infertility clinic: a longitudinal study
verfasst von
Xue-Fen Cai
Jian-Ming Zhao
Yi-Song Yang
Cai-Yun Wang
Mei-Xin Nian
Jie-Feng Huang
Bi-Ying Wang
Publikationsdatum
07.12.2022
Verlag
Springer International Publishing
Erschienen in
Sleep and Breathing
Print ISSN: 1520-9512
Elektronische ISSN: 1522-1709
DOI
https://doi.org/10.1007/s11325-022-02756-2

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