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Erschienen in:
25.05.2017 | Original Paper
Sensitivity and specificity of optical coherence tomography angiography (OCT-A) for detection of choroidal neovascularization in real-life practice and varying retinal expertise level
Erschienen in: International Ophthalmology | Ausgabe 3/2018
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Purpose
To evaluate the diagnostic accuracy of OCT angiography (OCT-A) detecting or predicting choroidal neovascularization (CNV), by ophthalmologists of disparate degrees of skills in retinal diseases, using spectral domain optical coherence tomography (SD-OCT) and fluorescein angiography (FA) as a standard reference.
Methods
Retrospective observational case series. Patient presenting maculopathy and complete imaging were included. FA, SD-OCT, OCT-A and FA coupled to SD-OCT images were graded independently for presence or absence of CNV by ophthalmologists with varying expertise levels.
Results
Overall sensitivity of OCT-A was 85.62% (95% CI 79.04–90.76%) and specificity was 81.51% (95% CI 73.36–88.03). Sensitivity of FA was 74.51% (95% CI 66.84–81.20), and specificity was 82.35% (95% CI 74.30–88.73). Sensitivity of FA + SD-OCT was 92.72% (95% CI 87.34–96.30), and specificity was 90.91% (95% CI 84.31–95.37).
Conclusion
OCT-A has good sensitivity and specificity for the detection of CNV in all expertise level groups. OCT-A may soon become a routine tool for CNV diagnosis and follow-up.