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Archives of Virology

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18.01.2016 | Original Article

Sequence analysis and evaluation of the NS3/A gene region of bluetongue virus isolates from South Africa

verfasst von: Jumari Steyn, Estelle Hildegard Venter

Erschienen in: Archives of Virology | Ausgabe 4/2016

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Abstract

Phylogenetic networks and sequence analysis allow a more accurate understanding of the serotypes, genetic relationships and epidemiology of viruses. Based on gene sequences of the conserved segment 10 (NS3), bluetongue virus (BTV) can be divided into five topotypes. In this molecular epidemiology study, segment 10 sequence data of 11 isolates obtained from the Virology Section of the Department of Veterinary Tropical Diseases, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, were analyzed and compared to sequence data of worldwide BTV strains available in the GenBank database. The consensus nucleotide sequences of NS3/A showed intermediate levels of variation, with the nucleotide sequence identity ranging from 79.72 % to 100 %. All 11 strains demonstrated conserved amino acid characteristics. Phylogenetic networks were used to identify BTV topotypes. The phylogeny obtained from the nucleotide sequence data of the NS3/A-encoding gene presented three major and two minor topotypes. The clustering of strains from different geographical areas into the same group indicated spatial spread of the segment 10 genes, either through gene reassortment or through the introduction of new strains from other geographical areas via trade. The effect of reassortment and genetic drift on BTV and the importance of correct serotyping to identify viral strains are highlighted.

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Titel: Sequence analysis and evaluation of the NS3/A gene region of bluetongue virus isolates from South Africa
verfasst von: Jumari Steyn
Estelle Hildegard Venter
Publikationsdatum: 18.01.2016
Verlag: Springer Vienna
Erschienen in: Archives of Virology / Ausgabe 4/2016
Print ISSN: 0304-8608
Elektronische ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-015-2741-3

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