Fig. 1
Clinical course of our patient with dual chronic hepatitis E and B infection.
Upper panel Hepatitis E virus RNA was detected by reverse transcription-polymerase chain reaction followed by southern Blot analysis (
top).
Lanes 1–4, hepatitis E virus RNA detected from serum samples obtained from various time-points (
arrows). Changes of alanine transaminase (
orange circles and line), bilirubin (
grey), alpha-fetoprotein (
blue), and creatinine (
green) along the course are depicted. Positive (
solid horizontal bar) status of hepatitis E virus RNA; hepatitis C virus RNA and hepatitis B virus surface antigen are shown.
Lower panel Changes of hepatitis B virus DNA along the course.
Solid squares, positive hepatitis B virus DNA;
green squares, hepatitis B virus DNA undetectable. Time-points to detect the rtM204V mutation are marked by
arrows.
Bottom, the periods of time when lamivudine or adefovir were given (
solid horizontal bars). All serological and molecular virology assays are described in our previous publications [
6,
7].
ADV adefovir,
AFP alpha-fetoprotein,
ALT alanine transaminase,
BIL bilirubin,
Cr creatinine,
GR graft removed,
HBsAg hepatitis B virus surface antigen,
HBV hepatitis B virus,
HCV hepatitis C virus,
H/D hemodialysis,
HEV hepatitis E virus,
LAM lamivudine,
P positive hybridization control