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01.06.2005 | Original Contribution

Serologic Responses in Indeterminate Colitis Patients Before Ileal Pouch-Anal Anastomosis May Determine Those at Risk for Continuous Pouch Inflammation

verfasst von: Thomas Hui, M.D., Carol Landers, B.S., Eric Vasiliauskas, M.D., Maria Abreu, M.D., Marla Dubinsky, M.D., Konstantinos A. Papadakis, M.D., Joanne Price, M.S., Ying-Chao Lin, M.S., Yang Huiying, M.D., Ph.D., Stephan Targan, M.D., Phillip Fleshner, M.D.

Erschienen in: Diseases of the Colon & Rectum | Ausgabe 6/2005

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PURPOSE

Although acute pouchitis after ileal pouch-anal anastomosis is common and easily treated, continuous pouch inflammation seen clinically as chronic, antibiotic-dependent pouchitis, and/or Crohn’s disease remains a difficult management problem. Compared with ulcerative colitis, indeterminate colitis patients undergoing ileal pouch-anal anastomosis have a higher incidence of continuous pouch inflammation, which may represent persistent immune reactivity to microbial antigens. Antibody responses to three microbial antigens (oligomannan anti-Saccharomyces cerevisiae, outer membrane porin C of Escherichia coli, and an antigen (I2) from Pseudomonas flourescens) are more commonly seen in Crohn’s disease, whereas antibodies to a cross-reactive antigen (perinuclear antineutrophil cytoplasmic antibodies) is more suggestive of ulcerative colitis. We examined whether preoperative serologic responses to these antigens were associated with Crohn’s disease in indeterminate colitis patients after ileal pouch-anal anastomosis.

METHODS

Twenty-eight indeterminate colitis patients undergoing ileal pouch-anal anastomosis were prospectively assessed for the development of pouchitis or Crohn’s disease. Serologic responses were determined by enzyme-linked immunosorbent assay and immunofluorescence. Patients were classified based on four predominant profiles of antibody expression. Antibody profiles were determined before knowledge of clinical outcome.

RESULTS

Median follow-up was 38 (range, 3–75) months. Of 16 patients (61 percent) who developed pouch inflammation, 4 (25 percent) had acute pouchitis and 12 (75 percent) had continuous pouch inflammation (9 had chronic pouchitis, 3 had Crohn’s disease). No preoperative clinical factor predicted the development of these pouch complications. Overall, 16 patients (57 percent) had a positive antibody reactivity profile. Serologic expression of any marker alone did not predict the development of continuous pouch inflammation. However, continuous pouch inflammation developed in 10 of 16 patients (63 percent) who had a positive antibody reactivity profile compared with only 2 of 12 patients (17 percent) who had a negative antibody reactivity profile (P = 0.015).

CONCLUSIONS

Indeterminate colitis patients who have a positive antibody reactivity profile before ileal pouch-anal anastomosis have a significantly higher incidence of continuous pouch inflammation after surgery than those with a negative profile.
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Metadaten
Titel
Serologic Responses in Indeterminate Colitis Patients Before Ileal Pouch-Anal Anastomosis May Determine Those at Risk for Continuous Pouch Inflammation
verfasst von
Thomas Hui, M.D.
Carol Landers, B.S.
Eric Vasiliauskas, M.D.
Maria Abreu, M.D.
Marla Dubinsky, M.D.
Konstantinos A. Papadakis, M.D.
Joanne Price, M.S.
Ying-Chao Lin, M.S.
Yang Huiying, M.D., Ph.D.
Stephan Targan, M.D.
Phillip Fleshner, M.D.
Publikationsdatum
01.06.2005
Erschienen in
Diseases of the Colon & Rectum / Ausgabe 6/2005
Print ISSN: 0012-3706
Elektronische ISSN: 1530-0358
DOI
https://doi.org/10.1007/s10350-005-0013-0

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