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Diabetologia

Erschienen in:

07.04.2016 | Review

Serotonin competence of mouse beta cells during pregnancy

verfasst von: Lotte Goyvaerts, Anica Schraenen, Frans Schuit

Erschienen in: Diabetologia | Ausgabe 7/2016

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Abstract

Pregnancy is a key mammalian reproductive event in which growth and differentiation of the fetus imposes extra metabolic and hormonal demands on the mother. Its successful outcome depends on major changes in maternal blood circulation, metabolism and endocrine function. One example is the endocrine pancreas, where beta cells undergo a number of changes in pregnancy that result in enhanced functional beta cell mass in order to compensate for the rising metabolic needs for maternal insulin. During the last 5 years, a series of studies have increased our understanding of the molecular events involved in this functional adaptation. In the mouse, a prominent functional change during pregnancy is the capacity of some beta cells to produce serotonin. In this review we will discuss the mechanism and potential effects of pregnancy-related serotonin production in beta cells, considering functional consequences at the local intra-islet and systemic level.

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Titel: Serotonin competence of mouse beta cells during pregnancy
verfasst von: Lotte Goyvaerts
Anica Schraenen
Frans Schuit
Publikationsdatum: 07.04.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: Diabetologia / Ausgabe 7/2016
Print ISSN: 0012-186X
Elektronische ISSN: 1432-0428
DOI: https://doi.org/10.1007/s00125-016-3951-2

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