Background
Methods
Study population
Definitions
Exclusion criteria
Aortic dissection blood sample biobank
Serum measurements
Laboratory examinations
Lipid panel
Additional biochemistry
D-Dimer and CRP
Control group (ctrl)
Statistical analysis
Results
Basic clinical characteristics of patients
Control (n = 63) | Angina (n = 20) | AAD (n = 87) | P-value | TAAD (n = 37) | TBAD (n = 50) | P-value | |
---|---|---|---|---|---|---|---|
AAD vs Control | |||||||
AAD vs Angina | |||||||
Male, n (%) | 43 (68.25%) | 15(75.00%) | 65 (74.71%) | 0.657 | 27 (72.97%) | 38 (76.00%) | 0.75 |
Hypertension, n (%) | 21 (33.33%) | 8(40.00%) | 54 (62.69%) | 0.002* | 27 (72.97%) | 27 (54.00%) | 0.073 |
Smoking, n (%) | 19 (30.16%) | 7(35.00%) | 31 (35.63) | 0.774 | 12 (32.43%) | 19 (38.00%) | 0.594 |
DM, n (%) | 10 (15.87%) | 6(30.00%) | 26 (29.89%) | 0.123 | 11 (29.73%) | 15 (30.00%) | 0.978 |
Age, Yr | 53.44 ± 11.52 | 57.80 ± 2.11 | 53.87 ± 11.42 | 0.957 | 53.32 ± 11.12 | 54.1 ± 11.73 | 0.848 |
0.355 | |||||||
BMI | 21.8 ± 3.68 | 23.70 ± 0.73 | 22.87 ± 5.14 | 0.357 | 22.24 ± 3.92 | 24.02 ± 5.99 | 0.149 |
0.702 | |||||||
HR, bmp | 78.06 ± 9.6 | 79.45 ± 1.68 | 89.46 ± 12.68 | < 0.001*** | 90.49 ± 11.86 | 88.21 ± 13.28 | 0.273 |
0.001*** | |||||||
WBC, × 109/L | 5.83 ± 0.77 | 6.39 ± 0.40 | 10.74 ± 4.24 | < 0.001*** | 11.54 ± 4.50 | 10.06 ± 3.92 | 0.198 |
< 0.001*** | |||||||
HGB, g/L | 150.98 ± 17.68 | 135.50 ± 4.08 | 132.39 ± 20.97 | < 0.001*** | 128.63 ± 17.86 | 135.61 ± 23.03 | 0.052 |
0.297 | |||||||
PLT, × 109/L | 173.3 ± 43.14 | 201.35 ± 13.27 | 190.59 ± 68.15 | 0.194 | 199.34 ± 67.05 | 183.12 ± 69.00 | 0.196 |
0.744 | |||||||
FPG, mmol/L | 4.97 ± 4.87 | 5.54 ± 0.24 | 7.21 ± 2.42 | 0.001*** | 7.61 ± 2.84 | 6.92 ± 2.05 | 0.355 |
0.155 | |||||||
SAA, mg/L | 0.36 ± 0.08 | 0.72 ± 0.40 | 4.43 ± 0.31 | < 0.001*** | 4.22 ± 0.33 | 4.58 ± 0.48 | 0.595 |
0.029* |
Variables | Control | Angina | AAD | P Value | ||
---|---|---|---|---|---|---|
SAA (mg/L) | SAA (mg/L) | SAA (mg/L) | AAD vs Control | AAD vs angina | ||
Age | <60Yr | 0.418 ± 0.113 | 0.661 ± 0.333 | 4.436 ± 0.308 | < 0.001 | 0.033 |
≥60Yr | 0.263 ± 0.084 | 0.632 ± 0.323 | 6.850 ± 2.535 | < 0.001 | 0.023 | |
Gender | male | 0.375 ± 0.093 | 0.697 ± 0.295 | 5.542 ± 1.456 | < 0.001 | 0.014 |
female | 0.332 ± 0.146 | 0.446 ± 0.244 | 5.227 ± 0.444 | < 0.001 | 0.032 | |
BMI | < 25 | 0.300 ± 0.067 | 0.652 ± 0.301 | 5.879 ± 1.496 | < 0.001 | 0.017 |
≥25 | 0.652 ± 0.316 | 0.630 ± 0.364 | 4.369 ± 0.494 | < 0.001 | 0.016 | |
Hypertension | Yes | 0.445 ± 0.164 | 0.808 ± 0.204 | 4.892 ± 0.517 | < 0.001 | 0.024 |
No | 0.319 ± 0.085 | 0.535 ± 0.342 | 6.397 ± 2.771 | < 0.001 | 0.046 | |
Smoking history | Yes | 0.510 ± 0.215 | 0.728 ± 0.326 | 7.698 ± 2.990 | < 0.001 | 0.006 |
No | 0.297 ± 0.063 | 0.516 ± 0.278 | 4.225 ± 0.344 | < 0.001 | 0.030 | |
DM | Yes | 0.232 ± 0.093 | 0.566 ± 0.356 | 8.157 ± 3.569 | < 0.001 | 0.007 |
No | 0.385 ± 0.093 | 0.677 ± 0.311 | 4.314 ± 0.317 | < 0.001 | 0.047 |
Parameters | TAAD | TBAD | P value | less than 6 h | more than 6 h | P value | communicating false lumen | non-communicating false lumen | P value | Death | Survival | P value |
---|---|---|---|---|---|---|---|---|---|---|---|---|
WBC, × 109/L | 11.54 ± 4.5 | 10.06 ± 3.92 | 0.198 | 10.73 ± 4.75 | 10.75 ± 3.78 | 0.917 | 12.1 ± 5.8 | 10.41 ± 3.74 | 0.522 | 12.78 ± 4.05 | 9.96 ± 4.08 | 0.004 |
BA/WBC, % | 0.20 ± 0.23 | 0.28 ± 0.34 | 0.646 | 0.24 ± 0.3 | 0.25 ± 0.30 | 0.723 | 0.3 ± 0.28 | 0.23 ± 0.30 | 0.231 | 0.22 ± 0.21 | 0.26 ± 0.32 | 0.954 |
EO/WBC, % | 1.37 ± 1.65 | 0.89 ± 1.51 | 0.139 | 0.95 ± 1.37 | 1.26 ± 1.76 | 0.409 | 1.04 ± 1.34 | 1.13 ± 1.65 | 0.783 | 0.66 ± 1.06 | 1.28 ± 1.72 | 0.039* |
MO/WBC, % | 13.29 ± 14.10 | 8.48 ± 9.03 | 0.002** | 9.29 ± 7.37 | 11.96 ± 14.7 | 0.909 | 15.02 ± 19.28 | 9.63 ± 9.04 | 0.648 | 9.21 ± 9.16 | 11.26 ± 12.71 | 0.227 |
LY/WBC, % | 14.87 ± 9.26 | 15.98 ± 9.1 | 0.462 | 14.76 ± 8.5 | 16.1 ± 9.72 | 0.596 | 14.24 ± 8.78 | 15.77 ± 9.26 | 0.514 | 11.62 ± 5.68 | 16.94 ± 9.79 | 0.043* |
NE/WBC, % | 69.92 ± 15.24 | 74.31 ± 12.97 | 0.198 | 74.49 ± 12.41 | 70.31 ± 15.41 | 0.275 | 69.4 ± 18.71 | 73 ± 12.86 | 0.638 | 77.88 ± 10.9 | 70.15 ± 14.72 | 0.017* |
RBC, × 1012/L | 4.26 ± 0.64 | 4.52 ± 0.76 | 0.014* | 4.36 ± 0.65 | 4.43 ± 0.77 | 0.730 | 4.32 ± 0.80 | 4.42 ± 0.69 | 0.523 | 4.46 ± 0.82 | 4.38 ± 0.68 | 0.582 |
HGB, g/L | 128.63 ± 17.86 | 135.61 ± 23.03 | 0.052 | 134.92 ± 18.44 | 130.13 ± 23 | 0.328 | 126.73 ± 27.9 | 133.79 ± 18.92 | 0.497 | 131.19 ± 25.29 | 132.85 ± 19.31 | 0.968 |
MCH, pg | 30.45 ± 3.12 | 30.49 ± 1.94 | 0.373 | 31.06 ± 2.15 | 29.94 ± 2.75 | 0.015* | 29.89 ± 4.59 | 30.61 ± 1.73 | 0.958 | 29.68 ± 3.41 | 30.77 ± 2.07 | 0.104 |
MCV, fL | 91.66 ± 8.00 | 92.11 ± 5.52 | 0.696 | 93.2 ± 5.67 | 90.74 ± 7.43 | 0.181 | 90.10 ± 11.44 | 92.35 ± 5.01 | 0.681 | 89.83 ± 9.28 | 92.69 ± 5.36 | 0.168 |
MCHC, g/L | 331.77 ± 11.11 | 331.12 ± 11.83 | 0.731 | 333.17 ± 9.78 | 329.85 ± 12.65 | 0.348 | 330.8 ± 17.09 | 331.57 ± 9.75 | 0.445 | 329.81 ± 11.29 | 332.04 ± 11.53 | 0.183 |
HCT, L/L | 0.38 ± 0.06 | 0.41 ± 0.07 | 0.083 | 0.41 ± 0.06 | 0.39 ± 0.08 | 0.428 | 0.38 ± 0.09 | 0.40 ± 0.06 | 0.567 | 0.39 ± 0.08 | 0.40 ± 0.06 | 0.802 |
RDW, % | 13.73 ± 2.43 | 13.25 ± 1.3 | 0.864 | 13.38 ± 1.47 | 13.51 ± 2.17 | 0.753 | 14.26 ± 2.64 | 13.25 ± 1.59 | 0.253 | 13.74 ± 1.78 | 13.33 ± 1.89 | 0.089 |
PLT, ×109/L | 199.34 ± 67.05 | 183.12 ± 69 | 0.196 | 177.75 ± 64.26 | 202.15 ± 70.25 | 0.218 | 166.07 ± 62.69 | 196.62 ± 68.56 | 0.168 | 182.33 ± 59.6 | 193.75 ± 71.4 | 0.597 |
MPV, fL | 9.48 ± 1.13 | 9.93 ± 1.67 | 0.158 | 9.95 ± 1.43 | 9.52 ± 1.46 | 0.380 | 9.51 ± 1.77 | 9.77 ± 1.39 | 0.675 | 9.91 ± 1.06 | 9.65 ± 1.58 | 0.480 |
PCT, L/L | 1.02 ± 2.26 | 0.36 ± 1.11 | 0.076 | 0.80 ± 1.99 | 0.56 ± 1.54 | 0.264 | 1.22 ± 2.57 | 0.55 ± 1.52 | 0.670 | 0.87 ± 2.10 | 0.59 ± 1.62 | 0.472 |
PDW, 10GSD | 14.51 ± 2.72 | 14.4 ± 2.90 | 0.657 | 14.9 ± 3.00 | 14.06 ± 2.59 | 0.260 | 15.26 ± 2.12 | 14.27 ± 2.91 | 0.308 | 14.51 ± 2.53 | 14.42 ± 2.92 | 0.489 |
TP, g/L | 63.93 ± 7.68 | 63.78 ± 10.34 | 0.540 | 64.76 ± 8.76 | 63.05 ± 9.56 | 0.410 | 61.72 ± 9.1 | 64.38 ± 9.19 | 0.277 | 62.27 ± 10.19 | 64.46 ± 8.77 | 0.591 |
PA, mg/dL | 15.96 ± 6.67 | 17.71 ± 6.29 | 0.231 | 14.18 ± 6.55 | 18.88 ± 5.74 | 0.005** | 16.94 ± 6.67 | 16.78 ± 6.52 | 0.868 | 14.75 ± 5.06 | 17.56 ± 6.83 | 0.177 |
ALB, g/L | 35.75 ± 6.12 | 36.84 ± 6.93 | 0.341 | 37.03 ± 6.36 | 35.75 ± 6.74 | 0.470 | 34.45 ± 7.3 | 36.82 ± 6.34 | 0.185 | 36.63 ± 7.29 | 36.23 ± 6.32 | 0.813 |
ALP, U/L | 106.79 ± 81.75 | 99.61 ± 43.41 | 0.583 | 104.84 ± 59.66 | 100.79 ± 66.18 | 0.793 | 102.42 ± 62.94 | 102.83 ± 63.19 | 0.925 | 103 ± 59.7 | 102.66 ± 64.29 | 0.773 |
ALT, U/L | 140.94 ± 407.11 | 57.24 ± 61.02 | 0.151 | 91.74 ± 203.78 | 98.2 ± 333.43 | 0.210 | 119.07 ± 305.66 | 89.22 ± 274.01 | 0.408 | 147.86 ± 454.6 | 74.7 ± 170.15 | 0.224 |
AST, U/L | 94 ± 364.89 | 60.56 ± 101.49 | 0.249 | 59.69 ± 101.85 | 91.36 ± 346.71 | 0.502 | 43.86 ± 45.18 | 83.97 ± 288.02 | 0.709 | 170.45 ± 488.11 | 41.54 ± 56.58 | 0.123 |
GGT, U/L | 128.38 ± 212.94 | 94.02 ± 122.55 | 0.766 | 139.77 ± 181.81 | 83.2 ± 154.87 | 0.057 | 127.2 ± 192.56 | 105.2 ± 164.37 | 0.942 | 99.95 ± 158.57 | 113.35 ± 174.47 | 0.402 |
CHE, 1000 U/L | 6.02 ± 1.65 | 5.96 ± 1.71 | 0.666 | 5.70 ± 1.54 | 6.22 ± 1.74 | 0.247 | 5.48 ± 1.68 | 6.13 ± 1.65 | 0.273 | 5.83 ± 1.54 | 6.05 ± 1.72 | 0.599 |
TBA, μmol/L | 4.76 ± 4.87 | 4.16 ± 5.86 | 0.312 | 5.84 ± 7.11 | 3.36 ± 2.95 | 0.170 | 4.19 ± 3.29 | 4.54 ± 5.79 | 0.873 | 3.15 ± 2.67 | 4.95 ± 5.97 | 0.415 |
DBIL, μmol/L | 8.93 ± 9.78 | 5.77 ± 2.84 | 0.493 | 9.7 ± 10.4 | 5.66 ± 3.36 | 0.122 | 8.72 ± 7.26 | 7.31 ± 8.06 | 0.463 | 6.58 ± 3.14 | 7.95 ± 8.77 | 0.815 |
TBIL, μmol/L | 17.95 ± 14.17 | 16.75 ± 8.70 | 0.568 | 20.2 ± 14.67 | 14.81 ± 6.88 | 0.103 | 18.37 ± 10.52 | 17.01 ± 11.68 | 0.389 | 16.06 ± 8.68 | 17.74 ± 12.29 | 0.742 |
CK, U/L | 186.1 ± 220.13 | 382 ± 1184.96 | 0.865 | 217.87 ± 314.36 | 360.08 ± 1186.69 | 0.940 | 287.88 ± 338.95 | 295.68 ± 974.92 | 0.122 | 562.31 ± 1711.62 | 203.15 ± 288.52 | 0.645 |
CKMB, U/L | 17.95 ± 9.85 | 22.39 ± 22.55 | 0.343 | 18.16 ± 8.53 | 21.32 ± 21.17 | 0.930 | 18.23 ± 9.23 | 20.25 ± 17.83 | 0.914 | 26.84 ± 28.62 | 17.31 ± 8.18 | 0.607 |
Urea, mmol/L | 7.56 ± 3.99 | 7.94 ± 8.41 | 0.127 | 7.84 ± 6.95 | 7.7 ± 6.56 | 0.640 | 8.29 ± 5.08 | 7.64 ± 7.08 | 0.296 | 7.87 ± 4.51 | 7.73 ± 7.41 | 0.646 |
Uric, mmol/L | 273.5 ± 159.03 | 352.75 ± 214.01 | 0.280 | 332.93 ± 185.1 | 277.47 ± 184.43 | 0.213 | 314.57 ± 211.96 | 302.35 ± 179.47 | 0.623 | 376.29 ± 204.76 | 283.57 ± 175.97 | 0.177 |
Crea mmol/L | 91.22 ± 43.83 | 111.17 ± 82.2 | 0.789 | 110.42 ± 66.54 | 88.13 ± 55.74 | 0.083 | 99.33 ± 70.69 | 98.91 ± 59.94 | 0.614 | 100.3 ± 22.1 | 98.58 ± 69.99 | 0.054 |
CYSC, mg/L | 1.30 ± 0.53 | 1.42 ± 0.95 | 0.990 | 1.38 ± 0.79 | 1.34 ± 0.73 | 0.654 | 1.54 ± 0.84 | 1.32 ± 0.74 | 0.412 | 1.35 ± 0.63 | 1.36 ± 0.81 | 0.837 |
C1q, mmol/L | 182.2 ± 35.56 | 200.05 ± 38.89 | 0.172 | 177.55 ± 36.91 | 198.33 ± 35.83 | 0.074 | 181.63 ± 33.57 | 191.32 ± 38.81 | 0.763 | 176.91 ± 31.95 | 191.81 ± 38.46 | 0.563 |
Na, mmol/L | 138.48 ± 4.85 | 141.52 ± 6.29 | 0.037* | 140.08 ± 7.12 | 140.15 ± 4.48 | 0.731 | 139.35 ± 8.79 | 140.3 ± 4.94 | 0.293 | 140.66 ± 6.7 | 139.91 ± 5.53 | 0.991 |
K, mmol/L | 3.63 ± 0.87 | 4.27 ± 0.66 | 0.015* | 3.92 ± 0.62 | 3.84 ± 1.02 | 0.724 | 4.18 ± 0.42 | 3.79 ± 0.91 | 0.095 | 3.7 ± 1.14 | 3.94 ± 0.74 | 0.274 |
CL, mmol/L | 103.36 ± 5.92 | 111.18 ± 7.39 | 0.000*** | 104.75 ± 8.74 | 108 ± 5.91 | 0.052 | 105.88 ± 11.64 | 106.56 ± 6.14 | 0.875 | 108.57 ± 8.95 | 105.71 ± 7.01 | 0.704 |
HCO3, mmol/L | 24.15 ± 2.41 | 23.98 ± 2.95 | 0.767 | 24.37 ± 2.47 | 23.76 ± 2.92 | 0.236 | 23.71 ± 2.39 | 24.14 ± 2.79 | 0.341 | 22.42 ± 2.71 | 24.69 ± 2.45 | 0.011* |
PH value | 6.93 ± 0.69 | 6.49 ± 1.08 | 0.106 | 7.06 ± 0.6 | 6.44 ± 1.02 | 0.021* | 6.5 ± 1.04 | 6.81 ± 0.85 | 0.915 | 6.8 ± 0.81 | 6.73 ± 0.93 | 0.649 |
TC, mmol/L | 4.19 ± 0.83 | 4.59 ± 1.17 | 0.255 | 4.62 ± 1.32 | 4.3 ± 0.84 | 0.589 | 4.92 ± 1.47 | 4.32 ± 0.93 | 0.361 | 4.51 ± 1.13 | 4.39 ± 1.03 | 0.333 |
TG, mmol/L | 1.34 ± 0.56 | 1.34 ± 0.67 | 0.834 | 1.24 ± 0.47 | 1.41 ± 0.71 | 0.677 | 1.5 ± 0.57 | 1.31 ± 0.63 | 0.283 | 1.23 ± 0.44 | 1.39 ± 0.69 | 0.664 |
ApoA1, mmol/L | 1.14 ± 0.18 | 1.21 ± 0.22 | 0.469 | 1.18 ± 0.17 | 1.18 ± 0.22 | 0.938 | 1.14 ± 0.31 | 1.19 ± 0.18 | 0.776 | 1.24 ± 0.16 | 1.14 ± 0.22 | 0.218 |
ApoB, mmol/L | 0.85 ± 0.22 | 0.76 ± 0.13 | 0.674 | 0.75 ± 0.22 | 0.83 ± 0.13 | 0.277 | 0.85 ± 0.13 | 0.79 ± 0.18 | 0.506 | 0.76 ± 0.2 | 0.82 ± 0.16 | 0.425 |
LDL-C, mmol/L | 2.58 ± 0.78 | 2.87 ± 1.06 | 0.246 | 2.87 ± 1.04 | 2.68 ± 0.92 | 0.620 | 3.23 ± 1.00 | 2.66 ± 0.94 | 0.133 | 2.65 ± 1.05 | 2.81 ± 0.93 | 0.899 |
HDL-C, mmol/L | 1.08 ± 0.34 | 1.22 ± 0.31 | 0.139 | 1.18 ± 0.25 | 1.16 ± 0.37 | 0.649 | 1.09 ± 0.38 | 1.19 ± 0.31 | 0.570 | 1.25 ± 0.25 | 1.13 ± 0.35 | 0.150 |
LDH, U/L | 451.88 ± 779.15 | 487.03 ± 489.75 | 0.138 | 505.85 ± 538.16 | 444.28 ± 694.87 | 0.171 | 410.67 ± 242.15 | 487.85 ± 692.2 | 0.645 | 826.64 ± 1148.14 | 359 ± 255.33 | 0.036* |
INR | 1.14 ± 0.22 | 1.08 ± 0.11 | 0.446 | 1.13 ± 0.21 | 1.09 ± 0.13 | 0.172 | 1.09 ± 0.12 | 1.11 ± 0.18 | 0.788 | 1.18 ± 0.26 | 1.08 ± 0.10 | 0.152 |
PT, s | 13.11 ± 2.41 | 13.28 ± 1.33 | 0.149 | 13.51 ± 2.27 | 12.96 ± 1.51 | 0.119 | 12.9 ± 1.57 | 13.28 ± 1.96 | 0.634 | 13.91 ± 2.65 | 12.89 ± 1.36 | 0.131 |
PTA, % | 85.87 ± 17.42 | 89.28 ± 12.04 | 0.615 | 85.62 ± 16.02 | 89.38 ± 13.59 | 0.198 | 88.54 ± 13.99 | 87.53 ± 15.01 | 0.974 | 83.4 ± 19.2 | 89.61 ± 12.04 | 0.279 |
APTT, s | 32.28 ± 5.28 | 35.79 ± 5.86 | 0.008** | 34.39 ± 6.11 | 34.04 ± 5.69 | 0.948 | 34.42 ± 6.43 | 34.14 ± 5.75 | 0.834 | 35.4 ± 6.4 | 33.67 ± 5.57 | 0.339 |
FPG, mmol/L | 7.61 ± 2.84 | 6.92 ± 2.05 | 0.355 | 7.2 ± 1.92 | 7.22 ± 2.81 | 0.281 | 6.38 ± 1.63 | 7.45 ± 2.57 | 0.069 | 7.90 ± 2.25 | 6.92 ± 2.46 | 0.032* |
CRP, mg/L | 95.73 ± 60.92 | 70.53 ± 76.14 | 0.115 | 90.4 ± 83.01 | 71.92 ± 61.85 | 0.597 | 79.43 ± 84.49 | 79.81 ± 69.09 | 0.889 | 138.21 ± 68.8 | 48.78 ± 50.86 | 0.000*** |
D-Dimer, μg/mL | 2.02 ± 3.57 | 4.10 ± 5.73 | 0.187 | 3.25 ± 4.94 | 3.09 ± 5.02 | 0.234 | 1.81 ± 1.69 | 3.49 ± 5.42 | 0.759 | 6.20 ± 6.91 | 1.83 ± 3.05 | 0.006** |
SAA, mg/L | 4.22 ± 0.33 | 4.58 ± 0.48 | 0.595 | 4.61 ± 0.42 | 4.21 ± 0.45 | 0.582 | 5.28 ± 0.81 | 4.44 ± 0.51 | 0.416 | 6.21 ± 0.65 | 3.78 ± 0.31 | 0.001*** |
Association of SAA levels with clinical features
Characterization | Indices | R | P value |
---|---|---|---|
Baseline Data | |||
Age, Yr | − 0.045 | 0.584 | |
BMI | 0.126 | 0.123 | |
HR, bmp | 0.333 | < 0.001*** | |
Blood routine | |||
WBC, ×109/L | 0.614 | < 0.001*** | |
RBC, ×1012/L | −0.111 | 0.354 | |
HGB, g/L | −0.395 | < 0.001*** | |
PLT, ×109/L | 0.091 | 0.285 | |
BA, ×109/L | −0.101 | 0.385 | |
EO, ×109/L | −0.243 | 0.035* | |
LY, ×109/L | −0.168 | 0.147 | |
MO, ×109/L | 0.085 | 0.468 | |
NE, ×109/L | 0.257 | 0.025* | |
MCH, pg | −0.065 | 0.574 | |
MCHC, g/L | −0.202 | 0.080 | |
MCV, fL | 0.015 | 0.898 | |
MPV, fL | −0.098 | 0.405 | |
HCT, L/L | −0.198 | 0.148 | |
PCT, L/L | −0.011 | 0.930 | |
PDW, 10GSD | 0.158 | 0.189 | |
RDW, % | 0.171 | 0.166 | |
Blood coagulation function | |||
APTT, s | −0.241 | 0.051 | |
PT, s | 0.03 | 0.811 | |
PTA, % | −0.258 | 0.037* | |
INR | 0.251 | 0.042* | |
D-Dimer, ug/ml | 0.206 | 0.097 | |
Cardiovascular injury-related parameters | |||
CK, U/L | −0.039 | 0.756 | |
CKMB, U/L | 0.213 | 0.198 | |
Inflammatory response | |||
CRP, mg/L | 0.442 | 0.001*** | |
Liver function | |||
ALB, g/L | −0.237 | 0.040* | |
ALP, U/L | 0.124 | 0.330 | |
ALT, U/L | 0.121 | 0.300 | |
AST, U/L | 0.163 | 0.166 | |
DBIL, umol/L | −0.098 | 0.553 | |
TBIL, umol/L | 0.012 | 0.922 | |
CHE, 1000 U/L | −0.258 | 0.053 | |
GGT, U/L | 0.028 | 0.811 | |
TBA, umol/L | 0.138 | 0.310 | |
TP, g/L | −0.177 | 0.128 | |
PA, mg/dL | −0.402 | 0.002** | |
LDH, U/L | 0.357 | 0.006** | |
Renal function and serum electrolyte | |||
Na, mmol/L | −0.141 | 0.224 | |
C1q, mmol/L | 0.026 | 0.883 | |
HCO3, mmol/L | −0.282 | 0.020* | |
CL, mmol/L | 0.175 | 0.274 | |
Crea, mmol/L | −0.116 | 0.469 | |
CYSC, mg/L | 0.248 | 0.046* | |
PH value | 0.113 | 0.523 | |
K, mmol/L | 0.074 | 0.644 | |
Urea, mmol/L | −0.049 | 0.672 | |
Uric, mmol/L | 0.182 | 0.336 | |
Serum lipid profile | |||
ApoA1, mmol/L | 0.117 | 0.623 | |
ApoB, mmol/L | −0.117 | 0.623 | |
FBG, mmol/L | 0.654 | < 0.001*** | |
HDL-C, mmol/L | 0.195 | 0.175 | |
TC, mmol/L | 0.063 | 0.678 | |
TG, mmol/L | −0.223 | 0.120 | |
LDL-C, mmol/L | 0.026 | 0.859 |
Diagnostic performance of SAA, CRP and their combination for AAD
AUC | 95%CI | P-value | cut-off | Sensitivity (%) | Specificity (%) | |
---|---|---|---|---|---|---|
AAD | 0.942 | 0.902–0.981 | < 0.001 | 0.427 | 0.908 | 0.937 |
TAAD | 0.939 | 0.873–1.004 | < 0.001 | 0.427 | 0.919 | 0.937 |
TBAD | 0.937 | 0.883–0.990 | < 0.001 | 0.462 | 0.881 | 0.937 |
Combination | ||||||
SAA + CRP | 0.977 | 0.955–0.999 | < 0.001 | – | 0.944 | 0.938 |
SAA + D-Dimer | 0.900 | 0.838–0.963 | < 0.001 | – | 0.848 | 0.938 |
Death | ||||||
SAA (death v.s. survival) | 0.732 | 0.612–0.853 | 0.001 | 4.998 | 0.739 | 0.625 |
CRP (death v.s. survival) | 0.826 | 0.709–0.942 | < 0.001 | 82.55 | 0.789 | 0.771 |
D-Dimer (death v.s. survival) | 0.715 | 0.562–0.869 | 0.006 | 1.945 | 0.700 | 0.739 |
NE% (death v.s. survival) | 0.678 | 0.549–0.808 | 0.017 | 72.976 | 0.857 | 0.491 |
The stratum of SAA according to gender and clinical biomarkers
SAA lower | SAA upper | P value | |
---|---|---|---|
OR (95%CI) | |||
Age, Yr | 1 Reference | 0.98 (0.92; 1.04) | 0.534 |
Hypertension, n | 1 Reference | 3.12 (0.76; 12.84) | 0.114 |
Smoker, n | 1 Reference | 1.64 (0.31; 8.54) | 0.558 |
D-Dimer, μg/mL | 1 Reference | 1.72 (0.79; 3.75) | 0.175 |
CRP, mg/L | 1 Reference | 1.05 (1.00; 1.09) | 0.039 |
CAD, n | 1 Reference | 1.49 (0.17; 13.14) | 0.719 |
Type01, n | 1 Reference | 1.11 (0.28; 4.50) | 0.879 |
WBC, ×109/L | 1 Reference | 1.74 (1.18; 2.56) | 0.005 |
RBC, ×1012/L | 1 Reference | 0.55 (0.18; 1.66) | 0.287 |
HGB, g/L | 1 Reference | 0.96 (0.92; 1.00) | 0.071 |
PLT, ×109/L | 1 Reference | 1.00 (0.99; 1.01) | 0.974 |
FPG, mmol/L | 1 Reference | 1.17 (0.80; 1.70) | 0.419 |
BA, ×109/L | 1 Reference | 0.18 (0.03; 1.20) | 0.076 |
EO, ×109/L | 1 Reference | 0.79 (0.01; 114.81) | 0.925 |
LY, ×109/L | 1 Reference | 0.85 (0.77; 0.93) | 0.000 |
MO, ×109/L | 1 Reference | 1.02 (0.94; 1.10) | 0.708 |
NE, ×109/L | 1 Reference | 1.97 (1.24; 3.11) | 0.004 |
CKMB, u/L | 1 Reference | 1.01 (0.89; 1.15) | 0.836 |
MCH, pg | 1 Reference | 0.83 (0.56; 1.21) | 0.332 |
MCHC, g/L | 1 Reference | 0.97 (0.91; 1.04) | 0.432 |
MCV, fL | 1 Reference | 0.95 (0.84; 1.08) | 0.459 |
MPV, fL | 1 Reference | 0.77 (0.47; 1.27) | 0.306 |
PCT, L/L | 1 Reference | 0.51 (0.01; 3.93) | 0.906 |
PDW, 10GSD | 1 Reference | 1.03 (0.80; 1.32) | 0.829 |
RDW, % | 1 Reference | 2.43 (0.99; 5.97) | 0.054 |
LDH, U/L | 1 Reference | 1.01 (1.00; 1.02) | 0.063 |
ALB, g/L | 1 Reference | 0.94 (0.84; 1.05) | 0.304 |
ALP, U/L | 1 Reference | 1.01 (0.99; 1.03) | 0.383 |
ALT, U/L | 1 Reference | 1.01 (0.99; 1.02) | 0.452 |
AST, U/L | 1 Reference | 1.00 (0.99; 1.02) | 0.567 |
GGT, U/L | 1 Reference | 1.00 (1.00; 1.01) | 0.529 |
DBIL, μmol/L | 1 Reference | 1.77 (0.71; 4.43) | 0.223 |
TBIL, μmol/L | 1 Reference | 1.02 (0.94; 1.10) | 0.617 |
PA, mg/dL | 1 Reference | 0.83 (0.71; 0.96) | 0.010 |
TP, g/L | 1 Reference | 0.97 (0.89; 1.05) | 0.396 |
TBA, μmol/L | 1 Reference | 0.97 (0.86; 1.10) | 0.668 |
K, mmol/L | 1 Reference | 3.31 (0.91; 12.06) | 0.070 |
CL, mmol/L | 1 Reference | 0.98 (0.81; 1.17) | 0.801 |
Na, mmol/L | 1 Reference | 0.95 (0.86; 1.05) | 0.313 |
HDL-C, mmol/L | 1 Reference | 1.06 (1.01; 1.10) | 0.014 |
LDL-C, mmol/L | 1 Reference | 1.27 (0.52; 3.11) | 0.605 |
TC, mmol/L | 1 Reference | 1.40 (0.56; 3.52) | 0.471 |
TG, mmol/L | 1 Reference | 0.50 (0.15; 1.60) | 0.240 |
Urea, mmol/L | 1 Reference | 1.17 (0.87; 1.55) | 0.295 |
Uric, mmol/L | 1 Reference | 1.01 (0.98; 1.05) | 0.389 |
Crea, mmol/L | 1 Reference | 1.09 (0.97; 1.23) | 0.133 |
C1q, mmol/L | 1 Reference | 1.03 (0.98; 1.08) | 0.264 |
HCO3, mmol/L | 1 Reference | 0.77 (0.57; 1.04) | 0.086 |
PH value | 1 Reference | 0.08 (0; 921.56) | 0.596 |
APTT, s | 1 Reference | 0.90 (0.80; 1.01) | 0.079 |
PT, s | 1 Reference | 1.08 (0.71; 1.64) | 0.724 |
PTA, s | 1 Reference | 0.96 (0.90; 1.02) | 0.164 |
Univariate and multivariate logistic regression analyses for in-hospital mortality
Model 1 | Model 2 | |||
---|---|---|---|---|
OR (95%CI) | P-value | OR (95%CI) | P-value | |
Type of AAD | 0.47 (0.16; 1.32) | 0.152 | 0.48 (0.17; 1.36) | 0.167 |
HR, bmp | 1.01 (0.97; 1.05) | 0.584 | 1.01 (0.97; 1.05) | 0.536 |
Hypertension, % | 1.22 (0.41; 3.64) | 0.724 | 1.13 (0.37; 3.40) | 0.832 |
Smoker, % | 0.63 (0.20; 1.96) | 0.421 | 0.63 (0.20; 2.00) | 0.432 |
D-Dimer, μg/mL | 1.19 (0.98; 1.43) | 0.074 | 1.20 (0.99; 1.46) | 0.065 |
CRP, mg/L | 1.02 (1.01; 1.03) | 0.000 | 1.03 (1.01; 1.04) | 0.000 |
WBC, ×109/L | 1.17 (1.03; 1.32) | 0.013 | 1.17 (1.03; 1.33) | 0.015 |
EO, ×109/L | 0.68 (0.40; 1.15) | 0.148 | 0.68 (0.40; 1.16) | 0.161 |
LY, ×109/L | 0.92 (0.85; 0.99) | 0.030 | 0.92 (0.85; 0.99) | 0.031 |
NE, ×109/L | 1.05 (1.00; 1.11) | 0.040 | 1.06 (1.00; 1.11) | 0.041 |
HCO3, mmol/L | 0.69 (0.53; 0.89) | 0.004 | 0.67 (0.51; 0.88) | 0.004 |
LDH, U/L | 1.00 (0.99; 1.00) | 0.097 | 1.00 (0.99; 1.00) | 0.151 |
FPG, mmol/L | 1.17 (0.95; 1.44) | 0.133 | 1.16 (0.95; 1.43) | 0.149 |
SAA, mg/L | 1.22 (1.05; 1.42) | 0.011 | 1.25 (1.07; 1.47) | 0.005 |