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10.11.2017 | Nephrology - Original Paper | Ausgabe 1/2018

International Urology and Nephrology 1/2018

Serum apolipoprotein B is inversely associated with eccentric left ventricular hypertrophy in peritoneal dialysis patients

International Urology and Nephrology > Ausgabe 1/2018
Min Ye, Yanqiu Liu, Haoyu Wang, Na Tian, Wei Li, Wei He, Hong Lin, Rui Fan, Cuiling Li, Donghong Liu, Fengjuan Yao
Wichtige Hinweise
Min Ye and Yanqiu Liu have contributed equally to this work.



The study aimed to examine the relationship of serum apolipoprotein B level with left ventricular (LV) structural and functional characteristics, in particular, LV remodeling parameters in peritoneal dialysis (PD) patients.


A total of 182 patients with end-stage renal disease (ESRD) receiving PD were identified. Conventional echocardiography was performed for each patient, and echocardiographic characteristics were analyzed according to apo B quartile groups. Multivariate linear regression models were used to determine the associations between serum apo B and LV remodeling indices.


A high serum apo B level was significantly related to the reduction in left atrium dimension (r = − 0.20, P = 0.011), LV dimensions (end-diastolic: r = − 0.27, P = 0.001; end-systolic: r = − 0.24, P = 0.003), peak velocities of early filling divided by peak velocities of atrial filling (r = − 0.38, P < 0.001), and LV volumetric dimension (end-diastolic: r = − 0.27, P < 0.001; end-systolic: r = − 0.28, P < 0.001). After adjustment for clinical confounding factors, the effect of serum apo B on LV eccentric remodeling modestly weakened but remained statistically significant (P = 0.038), while other associations were not significant. In multivariate linear regression analysis, conventional lipid profiles were not significantly associated with LV eccentric remodeling, whereas serum apo B was an independent determinant of LV dilatation (β: − 42.10, 95% CI − 74.82 to − 9.38, P = 0.012).


Serum apo B was significantly and inversely associated with LV dilatation, independently of conventional lipids and other CV risk factors in our ESRD patients undergoing PD. It suggested that low serum apo B level could be a powerful risk marker for eccentric left ventricular geometry remodeling and could be potentially used to risk-stratify PD patients.

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