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08.12.2016 | Original Article

Serum bilirubin concentrations and incident coronary heart disease risk among patients with type 2 diabetes: the Dongfeng–Tongji cohort

verfasst von: Jing Wang, Xiaofen Wu, Yaru Li, Xu Han, Hua Hu, Fei Wang, Caizheng Yu, Xiulou Li, Kun Yang, Jing Yuan, Ping Yao, Xiaoping Miao, Sheng Wei, Youjie Wang, Weihong Chen, Yuan Liang, Huan Guo, Handong Yang, Tangchun Wu, Xiaomin Zhang, Meian He

Erschienen in: Acta Diabetologica | Ausgabe 3/2017

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Abstract

Aims

Elevated serum bilirubin levels are associated with decreased coronary heart disease (CHD) risk in cross-sectional studies among diabetic patients, but prospective evidence is limited. We investigated the relationship of serum bilirubin levels with incident CHD risk among type 2 diabetes patients.

Methods

In a prospective study of 2918 type 2 diabetes embedded in the Dongfeng–Tongji cohort, serum total bilirubin (TBil), direct bilirubin (DBil), and indirect bilirubin (IBil) were measured at baseline. Cox proportional hazards models were used to examine the association between serum bilirubin levels and CHD risk.

Results

A total of 440 CHD cases were identified during 12,017 person-years of follow-up. Compared with extreme quartiles, the adjusted hazard ratio and 95% confidence interval of incident CHD were 0.74 (0.56–0.99) with P trend = 0.08 in IBil, while in TBil and DBil, the bilirubin–CHD associations were not significant. Moreover, serum TBil and IBil levels were interacted with drinking status on the risk of incident CHD (P interaction = 0.021 and 0.037, respectively), and the associations were evident in ever drinkers. In drinkers, when serum TBil or IBil concentrations increased 1 μmol/L, the CHD risk both decreased 6% (95% CIs 0.89–0.99 and 0.87–1.00, respectively).

Conclusions

Serum IBil levels were marginally related to decreased incident CHD risk among type 2 diabetes. Drinking could potentially enhance the associations of serum TBil and DBil levels with incident CHD risk.

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Titel: Serum bilirubin concentrations and incident coronary heart disease risk among patients with type 2 diabetes: the Dongfeng–Tongji cohort
verfasst von: Jing Wang
Xiaofen Wu
Yaru Li
Xu Han
Hua Hu
Fei Wang
Caizheng Yu
Xiulou Li
Kun Yang
Jing Yuan
Ping Yao
Xiaoping Miao
Sheng Wei
Youjie Wang
Weihong Chen
Yuan Liang
Huan Guo
Handong Yang
Tangchun Wu
Xiaomin Zhang
Meian He
Publikationsdatum: 08.12.2016
Verlag: Springer Milan
Erschienen in: Acta Diabetologica / Ausgabe 3/2017
Print ISSN: 0940-5429
Elektronische ISSN: 1432-5233
DOI: https://doi.org/10.1007/s00592-016-0946-x

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Serum bilirubin concentrations and incident coronary heart disease risk among patients with type 2 diabetes: the Dongfeng–Tongji cohort

Abstract

Aims

Methods

Results

Conclusions

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