Background
Methods
Study population
Sandwich enzyme-linked immunosorbent assay (ELISA) for determining HSP47 concentration
Measurement of serum KL-6, SP-A, SP-D, and LDH levels
Immunohistochemistry
Statistical analysis
Results
Patient characteristics
Healthy volunteer (N = 19) | COP (N = 12) | NSIP (N = 16) | IPF (N = 19) | AIP (N = 9) | p value | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Age (years) | 35* | (27-59) | 65.5 | (38-87) | 57.0 | (28-74) | 64.0 | (34-75) | 75.0 | (53-81) | <0.001 |
Sex (male/female) | 11/8 | 7/5 | 6/10 | 13/6 | 6/3 | N.S. | |||||
Smoking (s/ex/n) | 0/0/19 | 2/4/6 | 3/5/8 | 6/5/8 | 5/1/3 | 0.002 | |||||
P/F ratio (mmHg) | - | 385.0 | (289.5-490.5) | 399.3 | (343.3-442.4) | 389.8 | (283.3-491.9) | 102.3¶
| (59.9-254.8) | <0.001 | |
A-a DO2 (mmHg) | - | 19.9 | (-5.14-46.9) | 15.3 | (2.6-37.9) | 17.1 | (-3.5-52.7) | 402¶
| (58.6-611.4) | <0.001 |
Disease outcomes
Serum levels of HSP47, KL-6, SP-A, SP-D and LDH
Healthy volunteer (N = 19) | [n] | COP (N = 12) | [n] | NSIP (N = 16) | [n] | IPF (N = 19) | [n] | AIP (N = 9) | [n] | p value | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
HSP47 (pg/mL) | 565.8 | (332.1-879.8) | [19] | 239.1 | (16.6-476.6) | [12] | 290.7 | (24.8-603.0) | [16] | 330.9 | (105.1-487.6) | [19] | 1530.2* | (1075.1-3919.9) | [9] | <0.001 |
KL-6 (U/mL) | 193.0 | (144-322) | [19] | 427.5 | (172-1310) | [10] | 1568.5¶
| (192-4745) | [14] | 1460¶
| (444-4340) | [15] | 332.5 | (201-2200) | [8] | <0.001 |
SP-A (ng/mL) | 22.7 | (12.1-60.8) | [19] | 52.8 | (20.6-129) | [8] | 48.9 | (20.3-127) | [12] | 103§
| (62.4-355) | [15] | 138£
| (43.8-148) | [6] | <0.001 |
SP-D (ng/mL) | 17.3 | (17.3-58.6) | [19] | 105.7 | (27.8-247) | [8] | 477.0 | (17.2-942) | [13] | 316.0 | (93.1-721) | [14] | 417#
| (72.1-4510) | [8] | <0.001 |
LDH (IU/L) | 124.5 | (20-246) | [19] | 164.0 | (132-236) | [12] | 212.5#
| (135-738) | [14] | 233#
| (113-416) | [15] | 380* | (231-736) | [9] | <0.001 |