nach oben

Journal of Endocrinological Investigation

Erschienen in:

01.06.2019 | Review Article

Serum levels of adipokines in gestational diabetes: a systematic review

verfasst von: I. Bellos, G. Fitrou, V. Pergialiotis, D. N. Perrea, G. Daskalakis

Erschienen in: Journal of Endocrinological Investigation | Ausgabe 6/2019

Einloggen, um Zugang zu erhalten

Abstract

Objective

To determine the difference of serum levels of 10 adipokines (apelin, chemerin, fatty acid-binding protein-4, fibroblast growth factor-21, monocyte chemoattractant protein-1, nesfatin-1, omentin-1, resistin, vaspin, and visfatin) among women with gestational diabetes and healthy pregnant controls.

Materials and methods

Literature search was conducted using the Medline (1966–2018), Scopus (2004–2018), Cochrane Central Register of Controlled Trials (CENTRAL) (1999–2018), Clinicaltrials.gov (2008–2018) and Google Scholar (2004–2018) databases, along with the reference list of the included studies.

Results

Ninety-one studies were included in the present review, with a total number of 11,074 pregnant women. A meta-analysis was not conducted due to the high inter-study heterogeneity. Current evidence suggests that fatty acid-binding protein-4 levels are significantly increased in pregnancies complicated with gestational diabetes, while no association of serum apelin and monocyte chemoattractant protein-1 with the disease can be supported. Data regarding the rest adipokines are conflicting, since the available studies did not unanimously indicate a significant change of their levels in gestational diabetes.

Conclusions

The findings of the present systematic review suggest the promising role of fatty acid-binding protein-4 in the prediction of gestational diabetes, while inconsistent evidence exists regarding the rest novel adipokines. Future cohorts are needed to assess their predictive efficacy and fully elucidate their contribution in the disease.

Nur mit Berechtigung zugänglich

Guariguata L, Linnenkamp U, Beagley J, Whiting DR, Cho NH (2014) Global estimates of the prevalence of hyperglycaemia in pregnancy. Diabetes Res Clin Pract 103:176–185. https://doi.org/10.1016/j.diabres.2013.11.003 CrossRefPubMed

HAPO Study Cooperative Research Group, Metzger BE, Lowe LP, Dyer AR, Trimble ER, Chaovarindr U, Coustan DR, Hadden DR, McCance DR, Hod M, McIntyre HD, Oats JJN, Persson B, Rogers MS, Sacks DA (2008) Hyperglycemia and adverse pregnancy outcomes. N Engl J Med 358:1991–2002. https://doi.org/10.1056/nejmoa0707943 CrossRef

Bellamy L, Casas J-P, Hingorani AD, Williams D (2009) Type 2 diabetes mellitus after gestational diabetes: a systematic review and meta-analysis. Lancet 373:1773–1779. https://doi.org/10.1016/S0140-6736(09)60731-5 CrossRefPubMed

Li J, Song C, Li C, Liu P, Sun Z, Yang X (2018) Increased risk of cardiovascular disease in women with prior gestational diabetes: a systematic review and meta-analysis. Diabetes Res Clin Pract 140:324–338. https://doi.org/10.1016/j.diabres.2018.03.054 CrossRefPubMed

Cossu E, Incani M, Pani MG, Gattu G, Serafini C, Strazzera A, Bertoccini L, Cimini FA, Barchetta I, Cavallo MG, Baroni MG (2018) Presence of diabetes-specific autoimmunity in women with gestational diabetes mellitus (GDM) predicts impaired glucose regulation at follow-up. J Endocrinol Invest 41:1061–1068. https://doi.org/10.1007/s40618-018-0830-3 CrossRefPubMed

Chiefari E, Arcidiacono B, Foti D, Brunetti A (2017) Gestational diabetes mellitus: an updated overview. J Endocrinol Invest 40:899–909. https://doi.org/10.1007/s40618-016-0607-5 CrossRefPubMed

Law KP, Zhang H (2017) The pathogenesis and pathophysiology of gestational diabetes mellitus: deductions from a three-part longitudinal metabolomics study in China. Clin Chim Acta 468:60–70. https://doi.org/10.1016/j.cca.2017.02.008 CrossRefPubMed

Poon LC, David McIntyre H, Hyett JA, Fonseca EBD, Hod M, FIGO Pregnancy and NCD Committee (2018) The first-trimester of pregnancy—a window of opportunity for prediction and prevention of pregnancy complications and future life. Diabetes Res Clin Pract. https://doi.org/10.1016/j.diabres.2018.05.002 CrossRefPubMed

Rönö K, Stach-Lempinen B, Klemetti MM, Kaaja RJ, Pöyhönen-Alho M, Eriksson JG, Koivusalo SB, RADIEL group (2014) Prevention of gestational diabetes through lifestyle intervention: study design and methods of a Finnish randomized controlled multicenter trial (RADIEL). BMC Pregnancy Childbirth 14:70. https://doi.org/10.1186/1471-2393-14-70 CrossRefPubMedPubMedCentral

10.

Nitert MD, Barrett HL, Foxcroft K, Tremellen A, Wilkinson S, Lingwood B, Tobin JM, McSweeney C, O’Rourke P, McIntyre HD, Callaway LK (2013) SPRING: an RCT study of probiotics in the prevention of gestational diabetes mellitus in overweight and obese women. BMC Pregnancy Childbirth 13:50. https://doi.org/10.1186/1471-2393-13-50 CrossRefPubMedPubMedCentral

11.

Haw JS, Galaviz KI, Straus AN, Kowalski AJ, Magee MJ, Weber MB, Wei J, Narayan KMV, Ali MK (2017) Long-term sustainability of diabetes prevention approaches: a systematic review and meta-analysis of randomized clinical trials. JAMA Intern Med 177:1808–1817. https://doi.org/10.1001/jamainternmed.2017.6040 CrossRefPubMedPubMedCentral

12.

Farrar D, Simmonds M, Bryant M, Lawlor DA, Dunne F, Tuffnell D, Sheldon TA (2017) Risk factor screening to identify women requiring oral glucose tolerance testing to diagnose gestational diabetes: a systematic review and meta-analysis and analysis of two pregnancy cohorts. PLoS One 12:e0175288. https://doi.org/10.1371/journal.pone.0175288 CrossRefPubMedPubMedCentral

13.

Blüher M (2014) Adipokines—removing road blocks to obesity and diabetes therapy. Mol Metab 3:230–240. https://doi.org/10.1016/j.molmet.2014.01.005 CrossRefPubMedPubMedCentral

14.

Freitas Lima LC, Braga VDA, Socorro D, de França SM, Cruz JDC, Sousa Santos SH, de Oliveira Monteiro MM, Balarini CDM (2015) Adipokines, diabetes and atherosclerosis: an inflammatory association. Front Physiol 6:304. https://doi.org/10.3389/fphys.2015.00304 CrossRefPubMedPubMedCentral

15.

Bao W, Baecker A, Song Y, Kiely M, Liu S, Zhang C (2015) Adipokine levels during the first or early second trimester of pregnancy and subsequent risk of gestational diabetes mellitus: a systematic review HHS Public Access. Metabolism 64:756–764. https://doi.org/10.1016/j.metabol.2015.01.013 CrossRefPubMedPubMedCentral

16.

Xu J, Zhao YH, Chen YP, Yuan XL, Wang J, Zhu H, Lu CM (2014) Maternal circulating concentrations of tumor necrosis factor-alpha, leptin, and adiponectin in gestational diabetes mellitus: a systematic review and meta-analysis. Sci World J 2014:1–12. https://doi.org/10.1155/2014/926932 CrossRef

17.

Hu S, Liu Q, Huang X, Tan H (2016) Serum level and polymorphisms of retinol-binding protein-4 and risk for gestational diabetes mellitus: a meta-analysis. BMC Pregnancy Childbirth 16:52. https://doi.org/10.1186/s12884-016-0838-7 CrossRefPubMedPubMedCentral

18.

Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JPA, Clarke M, Devereaux PJ, Kleijnen J, Moher D (2009) The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ 339:b2700CrossRef

19.

Wells G, Shea B, O’Connell J, Peterson J, Welch V, Losos M, Tugwell (2011) The Newcastle–Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analysis. http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp. Accessed 1 July 2018

20.

Abell SK, Shorakae S, Harrison CL, Hiam D, Moreno-Asso A, Stepto NK, De Courten B, Teede HJ (2017) The association between dysregulated adipocytokines in early pregnancy and development of gestational diabetes. Diabetes Metab Res Rev 33:e2926. https://doi.org/10.1002/dmrr.2926 CrossRef

21.

Ademoglu E, Berberoglu Z, Dellal F, Keskin Ariel M, Kose A, Candan Z, Bekdemir H, Erdamar H, Culha C, Aral Y, Berberoglu Z (2015) Higher levels of circulating chemerin in obese women With gestational diabetes mellitus. Gen Endocrinol Acta Endocrinol. XI:32–37. https://doi.org/10.4183/aeb.2015.32 CrossRef

22.

Ademoglu EN, Gorar S, Keskin M, Carlioglu A, Ucler R, Erdamar H, Culha C, Aral Y (2017) Serum nesfatin-1 levels are decreased in pregnant women newly diagnosed with gestational diabetes. Arch Endocrinol Metab 61:455–459. https://doi.org/10.1590/2359-3997000000288 CrossRefPubMed

23.

Akturk M, Altinova AE, Mert I, Buyukkagnici U, Sargin A, Arslan M, Danisman N (2008) Visfatin concentration is decreased in women with gestational diabetes mellitus in the third trimester. J Endocrinol Invest 31:610–613. https://doi.org/10.1007/BF03345611 CrossRefPubMed

24.

Aslan M, Celik O, Celik N, Turkcuoglu I, Yilmaz E, Karaer A, Simsek Y, Celik E, Aydin S (2012) Cord blood nesfatin-1 and apelin-36 levels in gestational diabetes mellitus. Endocrine 41:424–429. https://doi.org/10.1007/s12020-011-9577-8 CrossRefPubMed

25.

Barker G, Lim R, Georgiou HM, Lappas M (2012) Omentin-1 is decreased in maternal plasma, placenta and adipose tissue of women with pre-existing obesity. PLoS One 7:e42943. https://doi.org/10.1371/journal.pone.0042943 CrossRefPubMedPubMedCentral

26.

Barker G, Lim R, Rice GE, Lappas M (2012) Increased chemerin concentrations in fetuses of obese mothers and correlation with maternal insulin sensitivity. J Matern Fetal Neonatal Med 25:2274–2280. https://doi.org/10.3109/14767058.2012.686540 CrossRefPubMed

27.

Boyadzhieva M, Atanasova I, Zacharieva S, Kedikova S (2013) Adipocytokines during pregnancy and postpartum in women with gestational diabetes and healthy controls. J Endocrinol Invest 36:944–949. https://doi.org/10.3275/8968 CrossRefPubMed

28.

Chan T-F, Chen Y-L, Lee C-H, Chou F-H, Wu L-C, Jong S-B, Tsai E-M (2006) Decreased plsma visfatin concentrations in women with gestational diabetes mellitus. J Soc Gynecol Investig 13:364–367. https://doi.org/10.1016/j.jsgi.2006.04.007 CrossRefPubMed

29.

Chen D, Fang Q, Chai Y, Wang H, Huang H, Dong M (2007) Serum resistin in gestational diabetes mellitus and early postpartum. Clin Endocrinol (Oxf) 67:208–211. https://doi.org/10.1111/j.1365-2265.2007.02862.x CrossRef

30.

Cortelazzi D, Corbetta S, Ronzoni S, Pelle F, Marconi A, Cozzi V, Cetin I, Cortelazzi R, Beck-Peccoz P, Spada A (2007) Maternal and foetal resistin and adiponectin concentrations in normal and complicated pregnancies. Clin Endocrinol (Oxf) 66:447–453. https://doi.org/10.1111/j.1365-2265.2007.02761.x CrossRef

31.

Coskun A, Ozkaya M, Kiran G, Kilinc M, Arikan DC (2010) Plasma visfatin levels in pregnant women with normal glucose tolerance, gestational diabetes and pre-gestational diabetes mellitus. J Matern Fetal Neonatal Med 23:1014–1018. https://doi.org/10.3109/14767050903551426 CrossRefPubMed

32.

Cundubey CR, Tayyar A (2017) Maternal and fetal apelin levels in gestational diabetes mellitus. Bozok Med J 7(3):58–66

33.

Dekker Nitert M, Barrett HL, Kubala MH, Scholz Romero K, Denny KJ, Woodruff TM, McIntyre HD, Callaway LK (2014) Increased placental expression of fibroblast growth factor 21 in gestational diabetes mellitus. J Clin Endocrinol Metab 99:E591–E598. https://doi.org/10.1210/jc.2013-2581 CrossRefPubMed

34.

Dimitrakaki A (2011) The role of leptin, adiponectin and resistin in gestational diabetes mellitus. http://thesis.ekt.gr/thesisBookReader/id/31698#page/1/mode/2up. Accessed 1 July 2018

35.

Fatima SS, Alam F, Chaudhry B, Khan TA (2017) Elevated levels of chemerin, leptin, and interleukin-18 in gestational diabetes mellitus. J Matern Fetal Neonatal Med 30:1023–1028. https://doi.org/10.1080/14767058.2016.1199671 CrossRefPubMed

36.

Ferreira AFA, Rezende JC, Vaikousi E, Akolekar R, Nicolaides KH (2011) Maternal serum visfatin at 11–13 weeks of gestation in gestational diabetes mellitus. Clin Chem 57:609–613. https://doi.org/10.1373/clinchem.2010.159806 CrossRefPubMed

37.

Franz M, Polterauer M, Springer S, Kuessel L, Haslinger P, Worda C, Worda K (2018) Maternal and neonatal omentin-1 levels in gestational diabetes. Arch Gynecol Obstet 297:885–889. https://doi.org/10.1007/s00404-018-4652-5 CrossRefPubMedPubMedCentral

38.

Gashlan HM (2017) Relationship between levels of retinol binding protein 4, vaspin and chemerin and insulin resistance in gestational diabetes mellitus. Int J Pharm Res Allied Sci 6:236–250

39.

Gkiomisi A, Makedou KG, Anastasilakis AD, Polyzos SA, Kourtis A, Gerou S, Gavana E, Dagklis T, Rousso D, Giannoulis C (2013) Serum vaspin levels in women with and without gestational diabetes mellitus during pregnancy and postpartum. Cytokine 61:127–132. https://doi.org/10.1016/j.cyto.2012.09.006 CrossRefPubMed

40.

Gok DE, Yazici M, Uckaya G, Bolu SE, Basaran Y, Ozgurtas T, Kilic S, Kutlu M (2011) The role of visfatin in the pathogenesis of gestational diabetes mellitus. J Endocrinol Invest 34:3–7. https://doi.org/10.1007/BF03346687 CrossRefPubMed

41.

Görkem Ü, Küçükler FK, Toğrul C, Güngör T (2016) Are adipokines associated with gestational diabetes mellitus? J Turkish Ger Gynecol Assoc 17:186–190. https://doi.org/10.5152/jtgga.2016.16112 CrossRef

42.

Guelfi KJ, Ong MJ, Li S, Wallman KE, Doherty DA, Fournier PA, Newnham JP, Keelan JA (2017) Maternal circulating adipokine profile and insulin resistance in women at high risk of developing gestational diabetes mellitus. Metabolism 75:54–60. https://doi.org/10.1016/j.metabol.2017.08.003 CrossRefPubMed

43.

Haider DG, Handisurya A, Storka A, Vojtassakova E, Luger A, Pacini G, Tura A, Wolzt M, Kautzky-Willer A (2007) Visfatin response to glucose is reduced in women with gestational diabetes mellitus. Diabetes Care 30:1889–1891. https://doi.org/10.2337/dc07-0013 CrossRefPubMed

44.

Hare KJ, Bonde L, Svare JA, Randeva HS, Asmar M, Larsen S, Vilsbøll T, Knop FK (2014) Decreased plasma chemerin levels in women with gestational diabetes mellitus. Diabet Med 31:936–940. https://doi.org/10.1111/dme.12436 CrossRefPubMed

45.

Hossein-Nezhad A, Mirzaei K, Maghbooli Z, Rahmani M, Larijani B (2010) Resistin, adiponectin and visfatin; can adipocytokines predict gestational diabetes mellitus and early post partum metabolic syndrome? Iran J Diabetes Lipid Disord 9:1–8

46.

Huang H, Xiao L, Wang A, Gu J, Ke H, Yan Y, Yang X (2016) Correlation of resistin expression in maternal serum and subcutaneous adipose tissue with insulin resistance in gestational diabetes mellitus. Int J Clin Exp Med 9:18721–18727

47.

Huo Y, Liu SX, Song GY, Ren LP, Wang C, Zhang DH (2015) Plasma levels and placental expression of vaspin in pregnant women with diabetes mellitus. Braz J Med Biol Res 48:273–279. https://doi.org/10.1590/1414-431X20143432 CrossRefPubMedPubMedCentral

48.

Huo Y, Liu S, Feng J, Li H, Fan Y, Jin Y, Li L (2014) Role of visfatin in the pathogenesis of gestational diabetes mellitus and its relationship with insulin resistance. Zhonghua Fu Chan Ke Za Zhi 49:584–587PubMed

49.

Jia X, Wang S, Ma N, Li X, Guo L, Liu X, Dong T, Liu Y, Lu Q (2015) Comparative analysis of vaspin in pregnant women with and without gestational diabetes mellitus and healthy non-pregnant women. Endocrine 48:533–540. https://doi.org/10.1007/s12020-014-0318-7 CrossRefPubMed

50.

Karatas A, Tunçay Işikkent N, Ozlü T, Demirin H (2014) Relationship of maternal serum resistin and visfatin levels with gestational diabetes mellitus. Gynecol Endocrinol 30:355–358. https://doi.org/10.3109/09513590.2014.887670 CrossRefPubMed

51.

Kaygusuz I, Gumus II, Yılmaz S, Simavlı S, Uysal S, Derbent AU, Gözdemir E, Kafalı H (2013) Serum levels of visfatin and possible interaction with iron parameters in gestational diabetes mellitus. Gynecol Obstet Invest 75:203–209. https://doi.org/10.1159/000348560 CrossRefPubMed

52.

Kim S-Y, Sy V, Araki T, Babushkin N, Huang D, Tan D, Liao E, Liu G, Wan S, Poretsky L, Seto-Young D (2014) Total adiponectin, but not inflammatory markers C-reactive protein, tumor necrosis factor-α, interluekin-6 and monocyte chemoattractant protein-1, correlates with increasing glucose intolerance in pregnant Chinese–Americans. J Diabetes 6:360–368. https://doi.org/10.1111/1753-0407.12114 CrossRefPubMedPubMedCentral

53.

Klein K, Satler M, Elhenicky M, Brix J, Krzyzanowska K, Schernthaner G, Husslein PW, Schernthaner G-H (2008) Circulating levels of MCP-1 are increased in women with gestational diabetes. Prenat Diagn 28:845–851. https://doi.org/10.1002/pd.2064 CrossRefPubMed

54.

Kralisch S, Stepan H, Kratzsch J, Verlohren M, Verlohren H-J, Drynda K, Lossner U, Bluher M, Stumvoll M, Fasshauer M (2009) Serum levels of adipocyte fatty acid binding protein are increased in gestational diabetes mellitus. Eur J Endocrinol 160:33–38. https://doi.org/10.1530/EJE-08-0540 CrossRefPubMed

55.

Krzyzanowska K, Krugluger W, Mittermayer F, Rahman R, Haider D, Shnawa N, Schernthaner G (2006) Increased visfatin concentrations in women with gestational diabetes mellitus. Clin Sci 110:605–609. https://doi.org/10.1042/CS20050363 CrossRefPubMed

56.

Kucukler FK, Gorkem U, Simsek Y, Kocabas R, Gulen S, Guler S (2016) Low level of Nesfatin-1 is associated with gestational diabetes mellitus. Gynecol Endocrinol 32:759–761. https://doi.org/10.1080/09513590.2016.1180679 CrossRefPubMed

57.

Kulik-Rechberger B, Mora-Janiszewska O (2009) Serum resistin concentrations in cases of gestational diabetes mellitus with good glycemic control and in cord blood. Ginekol Pol 80:432–436PubMed

58.

Kuzmicki M, Telejko B, Szamatowicz J, Zonenberg A, Nikolajuk A, Kretowski A, Gorska M (2009) High resistin and interleukin-6 levels are associated with gestational diabetes mellitus. Gynecol Endocrinol 25:258–263. https://doi.org/10.1080/09513590802653825 CrossRefPubMed

59.

Lain KY, Daftary AR, Ness RB, Roberts JM (2008) First trimester adipocytokine concentrations and risk of developing gestational diabetes later in pregnancy. Clin Endocrinol (Oxf) 69:407–411. https://doi.org/10.1111/j.1365-2265.2008.03198.x CrossRef

60.

Lappas M, Yee K, Permezel M, Rice GE (2005) Release and regulation of leptin, resistin and adiponectin from human placenta, fetal membranes, and maternal adipose tissue and skeletal muscle from normal and gestational diabetes mellitus-complicated pregnancies. J Endocrinol 186:457–465. https://doi.org/10.1677/joe.1.06227 CrossRefPubMed

61.

Lewandowski KC, Stojanovic N, Press M, Tuck SM, Szosland K, Bienkiewicz M, Vatish M, Lewinski A, Prelevic GM, Randeva HS (2007) Elevated serum levels of visfatin in gestational diabetes: a comparative study across various degrees of glucose tolerance. Diabetologia 50:1033–1037. https://doi.org/10.1007/s00125-007-0610-7 CrossRefPubMed

62.

Li L, Lee SJ, Kook SY, Ahn TG, Lee JY, Hwang JY (2017) Serum from pregnant women with gestational diabetes mellitus increases the expression of FABP4 mRNA in primary subcutaneous human pre-adipocytes. Obstet Gynecol Sci 60:274–282. https://doi.org/10.5468/ogs.2017.60.3.274 CrossRefPubMedPubMedCentral

63.

Li S, Wang W, Zhou L, Ma L, An Y, Xu W, Li T, Yu Y, Li D, Liu Y (2015) Fibroblast growth factor 21 expressions in white blood cells and sera of patients with gestational diabetes mellitus during gestation and postpartum. Endocrine 48:519–527. https://doi.org/10.1007/s12020-014-0309-8 CrossRefPubMed

64.

Li X-M, Ji H, Li C-J, Wang P-H, Yu P, Yu D-M (2015) Chemerin expression in Chinese pregnant women with and without gestational diabetes mellitus. Ann Endocrinol (Paris) 76:19–24. https://doi.org/10.1016/j.ando.2014.10.001 CrossRef

65.

Liang Z, Wu Y, Xu J, Fang Q, Chen D (2016) Correlations of serum visfatin and metabolisms of glucose and lipid in women with gestational diabetes mellitus. J Diabetes Investig 7:247–252. https://doi.org/10.1111/jdi.12385 CrossRef

66.

Lobo TF, Torloni MR, Mattar R, Nakamura MU, Alexandre SM, Daher S (2018) Adipokine levels in overweight women with early-onset gestational diabetes mellitus. J Endocrinol Invest. https://doi.org/10.1007/s40618-018-0894-0 CrossRefPubMed

67.

Ma Y, Cheng Y, Wang J, Cheng H, Zhou S, Li X (2010) The changes of visfatin in serum and its expression in fat and placental tissue in pregnant women with gestational diabetes. Diabetes Res Clin Pract 90:60–65. https://doi.org/10.1016/j.diabres.2010.06.010 CrossRefPubMed

68.

Maitland RA, Seed PT, Briley AL, Homsy M, Thomas S, Pasupathy D, Robson SC, Nelson SM, Sattar N, Poston L, UPBEAT trial consortium (2014) Prediction of gestational diabetes in obese pregnant women from the UK pregnancies better eating and activity (UPBEAT) pilot trial. Diabet Med 31:963–970. https://doi.org/10.1111/dme.12482 CrossRefPubMed

69.

McManus R, Summers K, de Vrijer B, Cohen N, Thompson A, Giroux I (2014) Maternal, umbilical arterial and umbilical venous 25-hydroxyvitamin D and adipocytokine concentrations in pregnancies with and without gestational diabetes. Clin Endocrinol (Oxf) 80:635–641. https://doi.org/10.1111/cen.12325 CrossRef

70.

Megia A, Gil-Lluis P, Näf S, Ceperuelo-Mallafré V, Gonzalez-Clemente JM, Llauradó G, Nuñez-Roa C, Roche K, Ballesteros M, Yañez RE, Fernández-Veledo S, Vendrell J (2015) Cord blood FGF21 in gestational diabetes and its relationship with postnatal growth. Acta Diabetol 52:693–700. https://doi.org/10.1007/s00592-014-0705-9 CrossRefPubMed

71.

Megia A, Vendrell J, Gutierrez C, Sabaté M, Broch M, Fernández-Real J-M, Simón I (2008) Insulin sensitivity and resistin levels in gestational diabetes mellitus and after parturition. Eur J Endocrinol 158:173–178. https://doi.org/10.1530/EJE-07-0671 CrossRefPubMed

72.

Mm WQ, Fan J, Khor S, Song M, Hong W, Dai X (2014) Serum vaspin levels and vaspin mRNA expression in subcutaneous adipose tissue in women with gestational diabetes mellitus. Eur J Obstet Gynecol Reprod Biol 182:98–101. https://doi.org/10.1016/j.ejogrb.2014.09.008 CrossRefPubMed

73.

Mouzaki M (2017) Investigation of the role of apelin in gestational diabetes mellitus. http://thesis.ekt.gr/thesisBookReader/id/42737#page/1/mode/2up. Accessed 1 July 2018

74.

Nanda S, Poon LCY, Muhaisen M, Acosta IC, Nicolaides KH (2012) Maternal serum resistin at 11–13 weeks’ gestation in normal and pathological pregnancies. Metabolism 61:699–705. https://doi.org/10.1016/j.metabol.2011.10.006 CrossRefPubMed

75.

Ning H, Tao H, Weng Z, Zhao X (2016) Plasma fatty acid-binding protein 4 (FABP4) as a novel biomarker to predict gestational diabetes mellitus. Acta Diabetol 53:891–898. https://doi.org/10.1007/s00592-016-0867-8 CrossRefPubMed

76.

Noureldeen AFH, Qusti SY, Al-seeni MN, Bagais MH (2014) Maternal leptin, adiponectin, resistin, visfatin and tumor necrosis factor-alpha in normal and gestational diabetes. Indian J Clin Biochem 29:462–470. https://doi.org/10.1007/s12291-013-0394-0 CrossRefPubMed

77.

Ortega-Senovilla H, Schaefer-Graf U, Meitzner K, Abou-Dakn M, Graf K, Kintscher U, Herrera E (2011) Gestational diabetes mellitus causes changes in the concentrations of adipocyte fatty acid-binding protein and other adipocytokines in cord blood. Diabetes Care 34:2061–2066. https://doi.org/10.2337/dc11-0715 CrossRefPubMedPubMedCentral

78.

Oztop N, Kusku Kiraz Z, Dervisoglu E, Dinccag N, Genc S (2016) The association of glycemic markers with plasma adipocytokine levels in women with gestational diabetes. J Diabetes Metab 7:2–5. https://doi.org/10.4172/2155-6156.1000699 CrossRef

79.

Palik E, Baranyi E, Melczer Z, Audikovszky M, Szöcs A, Winkler G, Cseh K (2007) Elevated serum acylated (biologically active) ghrelin and resistin levels associate with pregnancy-induced weight gain and insulin resistance. Diabetes Res Clin Pract 76:351–357. https://doi.org/10.1016/j.diabres.2006.09.005 CrossRefPubMed

80.

Park S, Kim M-Y, Baik SH, Woo J-T, Kwon YJ, Daily JW, Park Y-M, Yang J-H, Kim S-H (2013) Gestational diabetes is associated with high energy and saturated fat intakes and with low plasma visfatin and adiponectin levels independent of prepregnancy BMI. Eur J Clin Nutr 67:196–201. https://doi.org/10.1038/ejcn.2012.207 CrossRefPubMed

81.

Pfau D, Stepan H, Kratzsch J, Verlohren M, Verlohren H-J, Drynda K, Lössner U, Blüher M, Stumvoll M, Fasshauer M (2010) Circulating levels of the adipokine chemerin in gestational diabetes mellitus. Horm Res Paediatr 74:56–61. https://doi.org/10.1159/000282114 CrossRefPubMed

82.

Rezvan N, Hosseinzadeh-Attar MJ, Masoudkabir F, Moini A, Janani L, Mazaherioun M (2012) Serum visfatin concentrations in gestational diabetes mellitus and normal pregnancy. Arch Gynecol Obstet 285:1257–1262. https://doi.org/10.1007/s00404-011-2156-7 CrossRefPubMed

83.

Seto-Young D, Avtanski D, So-Young K, Sy V, Liao E, Liu G, Wan S, Lesser M, Poretsky L (2017) Insulin-like growth factor (IGF)-I. Clin Obstet Gynecol Reprod Med. https://doi.org/10.15761/cogrm.1000194 CrossRef

84.

Shang M, Dong X, Hou L (2018) Correlation of adipokines and markers of oxidative stress in women with gestational diabetes mellitus and their newborns. J Obstet Gynaecol Res 44:637–646. https://doi.org/10.1111/jog.13586 CrossRefPubMed

85.

Sharafeldeen A (2018) Serum adropin and adipose fatty-acid binding protein at 6th week of pregnancy are significant predictors for development of insulin resistance at the 24th week. Int J Adv Res 6:800–809. https://doi.org/10.21474/IJAR01/6496 CrossRef

86.

Shoman HA, Ali EA, Hussain AH, Waheed TN (2012) Role of Visfatin in the Pathogenesis of Gestational Diabetes Mellitus. Iraqi J Med Sci. 10(3):220–222. http://www.iraqijms.net/upload/pdf/iraqijms57013e504106d.pdf. Accessed 1 July 2018

87.

Siddiqui K, George TP, Nawaz SS, Shehata N, El-Sayed AA, Khanam L (2018) Serum adipokines (adiponectin and resistin) correlation in developing gestational diabetes mellitus: pilot study. Gynecol Endocrinol 34:502–506. https://doi.org/10.1080/09513590.2017.1411472 CrossRefPubMed

88.

Skvarca A, Tomazic M, Krhin B, Blagus R, Janez A (2012) Adipocytokines and insulin resistance across various degrees of glucose tolerance in pregnancy. J Int Med Res 40:583–589. https://doi.org/10.1177/147323001204000220 CrossRefPubMed

89.

Stein S, Stepan H, Kratzsch J, Verlohren M, Verlohren H-J, Drynda K, Lössner U, Blüher M, Stumvoll M, Fasshauer M (2010) Serum fibroblast growth factor 21 levels in gestational diabetes mellitus in relation to insulin resistance and dyslipidemia. Metabolism 59:33–37. https://doi.org/10.1016/j.metabol.2009.07.003 CrossRefPubMed

90.

Stepan H, Kralisch S, Klostermann K, Schrey S, Reisenbüchler C, Verlohren M, Verlohren H-J, Drynda K, Blüher M, Stumvoll M, Kratzsch J, Kovacs P, Fasshauer M (2010) Preliminary report: circulating levels of the adipokine vaspin in gestational diabetes mellitus and preeclampsia. Metabolism 59:1054–1056. https://doi.org/10.1016/j.metabol.2009.11.001 CrossRefPubMed

91.

Szamatowicz J, Kuźmicki M, Telejko B, Zonenberg A, Nikołajuk A, Kretowski A, Górska M (2009) Serum visfatin concentration is elevated in pregnant women irrespectively of the presence of gestational diabetes. Ginekol Pol 80:14–18PubMed

92.

Takhshid MA, Zare Z (2015) Resistin-420 C/G polymorphism and serum resistin level in Iranian patients with gestational diabetes mellitus. J Diabetes Metab Disord 14:37. https://doi.org/10.1186/s40200-015-0165-y CrossRefPubMedPubMedCentral

93.

Tan BK, Sivakumar K, Bari MF, Vatish M, Randeva HS (2013) Lower cerebrospinal fluid/plasma fibroblast growth factor 21 (FGF21) ratios and placental FGF21 production in gestational diabetes. PLoS One 8:e65254. https://doi.org/10.1371/journal.pone.0065254 CrossRefPubMedPubMedCentral

94.

Tang Y, Qiao P, Qu X, Bao Y, Li Y, Liao Y, Ying H (2017) Comparison of serum vaspin levels and vaspin expression in adipose tissue and smooth muscle tissue in pregnant women with and without gestational diabetes. Clin Endocrinol (Oxf) 87:344–349. https://doi.org/10.1111/cen.13403 CrossRef

95.

Telejko B, Kuzmicki M, Wawrusiewicz-Kurylonek N, Szamatowicz J, Nikolajuk A, Zonenberg A, Zwierz-Gugala D, Jelski W, Laudański P, Wilczynski J, Kretowski A, Gorska M (2010) Plasma apelin levels and apelin/APJ mRNA expression in patients with gestational diabetes mellitus. Diabetes Res Clin Pract 87:176–183. https://doi.org/10.1016/j.diabres.2009.10.018 CrossRefPubMed

96.

97.

Telejko B, Kuzmicki M, Zonenberg A, Niedziolko-Bagniuk K, Nikolajuk A, Szamatowicz J, Gorska M (2007) Circulating monocyte chemoattractant protein-1 in women with gestational diabetes. Folia Histochem Cytobiol 45(Suppl 1):S153–S156PubMed

98.

Telejko B, Kuzmicki M, Zonenberg A, Szamatowicz J, Wawrusiewicz-Kurylonek N, Nikolajuk A, Kretowski A, Gorska M (2009) Visfatin in gestational diabetes: serum level and mRNA expression in fat and placental tissue. Diabetes Res Clin Pract 84:68–75. https://doi.org/10.1016/j.diabres.2008.12.017 CrossRefPubMed

99.

Tsiotra PC, Halvatsiotis P, Patsouras K, Maratou E, Salamalekis G, Raptis SA, Dimitriadis G, Boutati E (2018) Circulating adipokines and mRNA expression in adipose tissue and the placenta in women with gestational diabetes mellitus. Peptides 101:157–166. https://doi.org/10.1016/j.peptides.2018.01.005 CrossRefPubMed

100.

Tu W-J, Guo M, Shi X-D, Cai Y, Liu Q, Fu C-W (2017) First-trimester serum fatty acid-binding protein 4 and subsequent gestational diabetes mellitus. Obstet Gynecol 130:1011–1016. https://doi.org/10.1097/AOG.0000000000002310 CrossRefPubMed

101.

Tuba Akdeniz F, Akbulut Z, Sarı H, Aydın H, Burak Dalan A, Şit D, İspir T, Yanikkaya Demirel G (2017) Effect of Pro-inflammatory Markers on gestational diabetes gebelik diyabetinde pro-enflamatuvar belirteçlerin etkisi. Turk J Immunol 5:45–50. https://doi.org/10.25002/tji.2017.586 CrossRef

102.

Vitoratos N, Deliveliotou A, Dimitrakaki A, Hassiakos D, Panoulis C, Deligeoroglou E, Creatsas GK (2011) Maternal serum resistin concentrations in gestational diabetes mellitus and normal pregnancies. J Obstet Gynaecol Res 37:112–118. https://doi.org/10.1111/j.1447-0756.2010.01327.x CrossRefPubMed

103.

Vitoratos N, Dimitrakaki A, Vlahos NF, Gregoriou O, Panoulis K, Christopoulos P, Creatsas G (2010) Maternal and umbilical resistin levels do not correlate with infant birth weight either in normal pregnancies and or in pregnancies complicated with gestational diabetes. J Matern Neonatal Med 23:1019–1023. https://doi.org/10.3109/14767050903551459 CrossRef

104.

Wang D, Zhu W, Li J, An C, Wang Z (2013) Serum concentrations of fibroblast growth factors 19 and 21 in women with gestational diabetes mellitus: association with insulin resistance, adiponectin, and polycystic ovary syndrome history. PLoS ONE 8:e81190. https://doi.org/10.1371/journal.pone.0081190 CrossRefPubMedPubMedCentral

105.

Xu L, Ping F, Yin J, Xiao X, Xiang H, Ballantyne CM, Wu H, Li M (2013) Elevated plasma SPARC levels are associated with insulin resistance, dyslipidemia, and inflammation in gestational diabetes mellitus. PLoS One 8:e81615. https://doi.org/10.1371/journal.pone.0081615 CrossRefPubMedPubMedCentral

106.

Yang X, Quan X, Lan Y, Ye J, Wei Q, Yin X, Fan F, Xing H (2017) Serum chemerin level during the first trimester of pregnancy and the risk of gestational diabetes mellitus. Gynecol Endocrinol 33:770–773. https://doi.org/10.1080/09513590.2017.1320382 CrossRefPubMed

107.

Zare Z, Meshkibaf M, Hamaitkhah V, Ranjbaran R, Takhshid M (2014) Positive correlation of resistin with blood lipids in gestational diabetes. J Fasa Univ Med Sci 3:330–335

108.

Zhang Y, Lu J-H, Zheng S-Y, Yan J-H, Chen L, Liu X, Wu W-Z, Wang F (2017) Serum levels of nesfatin-1 are increased in gestational diabetes mellitus. Gynecol Endocrinol 33:621–624. https://doi.org/10.1080/09513590.2017.1306849 CrossRefPubMed

109.

Zhang Y, Zhang H-H, Lu J-H, Zheng S-Y, Long T, Li Y-T, Wu W-Z, Wang F (2016) Changes in serum adipocyte fatty acid-binding protein in women with gestational diabetes mellitus and normal pregnant women during mid- and late pregnancy. J Diabetes Investig 7:797–804. https://doi.org/10.1111/jdi.12484 CrossRefPubMedPubMedCentral

110.

Zhaoxia L, Ying W, Danqing C (2012) Changes in visfatin levels after oral glucose tolerance test in women with gestational diabetes mellitus. Diabetes Res Clin Pract 96:e76–e79. https://doi.org/10.1016/j.diabres.2012.02.020 CrossRefPubMed

111.

Shang M, Lin L (2014) IADPSG criteria for diagnosing gestational diabetes mellitus and predicting adverse pregnancy outcomes. J Perinatol 34:100–104. https://doi.org/10.1038/jp.2013.143 CrossRefPubMed

112.

American Diabetes Association (2015) Standards of medical care in diabetes–2015: summary of revisions. Diabetes Care 38(Suppl):S4. https://doi.org/10.2337/dc15-S003 CrossRef

113.

World Health Organization (2006) Definition and diagnosis of diabetes mellitus and intermediate hyperglycemia Report of a WHO/IDF ConsultatIon. http://www.who.int/diabetes/publications/Definition%20and%20diagnosis%20of%20diabetes_new.pdf. Accessed 1 July 2018

114.

Carpenter MW, Coustan DR (1982) Criteria for screening tests for gestational diabetes. Am J Obstet Gynecol 144:768–773CrossRef

115.

National Diabetes Data Group (1979) Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes 28:1039–1057CrossRef

116.

Hoffman L, Nolan C, Wilson JD, Oats JJ, Simmons D (1998) Gestational diabetes mellitus–management guidelines. The Australasian diabetes in pregnancy society. Med J Aust 169:93–97CrossRef

117.

Kautzky-Willer A, Bancher-Todesca D, Weitgasser R, Prikoszovich T, Steiner H, Shnawa N, Schernthaner G, Birnbacher R, Schneider B, Marth C, Roden M, Lechleitner M (2008) The Impact of risk factors and more stringent diagnostic criteria of gestational diabetes on outcomes in central european women. J Clin Endocrinol Metab 93:1689–1695. https://doi.org/10.1210/jc.2007-2301 CrossRefPubMed

118.

Canadian Diabetes Association Clinical Practice Guidelines Expert Committee CA (2013) Canadian diabetes association 2013 clinical practice guidelines for the prevention and management of diabetes in Canada. Introd Can J Diabetes 37:S1–S3. https://doi.org/10.1016/j.jcjd.2013.01.009 CrossRef

119.

Akinci B, Celtik A, Tunali S, Genc S, Yuksel F, Secil M, Ozcan MA, Bayraktar F (2014) Circulating apelin levels are associated with cardiometabolic risk factors in women with previous gestational diabetes. Arch Gynecol Obstet 289:787–793. https://doi.org/10.1007/s00404-013-3070-y CrossRefPubMed

120.

Aviram A, Shtaif B, Gat-Yablonski G, Yogev Y (2018) The association between adipocytokines and glycemic control in women with gestational diabetes mellitus. J Matern Neonatal Med. https://doi.org/10.1080/14767058.2018.1487944 CrossRef

121.

Kurepa D, Pramanik AK, Kakkilaya V, Caldito G, Groome LJ, Bocchini JA, Jain SK (2012) Elevated acetoacetate and monocyte chemotactic protein-1 levels in cord blood of infants of diabetic mothers. Neonatology 102:163–168. https://doi.org/10.1159/000339286 CrossRefPubMedPubMedCentral

122.

Lowe LP, Metzger BE, Lowe WL, Dyer AR, McDade TW, McIntyre HD, HAPO Study Cooperative Research Group (2010) Inflammatory mediators and glucose in pregnancy: results from a subset of the hyperglycemia and adverse pregnancy outcome (HAPO) study. J Clin Endocrinol Metab 95:5427–5434. https://doi.org/10.1210/jc.2010-1662 CrossRefPubMedPubMedCentral

123.

Mazaki-Tovi S, Romero R, Kusanovic JP, Vaisbuch E, Erez O, Than NG, Chaiworapongsa T, Nhan-Chang C-L, Pacora P, Gotsch F, Yeo L, Kim SK, Edwin SS, Hassan SS, Mittal P (2009) Visfatin in human pregnancy: maternal gestational diabetes vis-à-vis neonatal birthweight. J Perinat Med 37:218–231. https://doi.org/10.1515/JPM.2009.053 CrossRefPubMedPubMedCentral

124.

Mousa A, Abell SK, Shorakae S, Harrison CL, Naderpoor N, Hiam D, Moreno-Asso A, Stepto NK, Teede HJ, de Courten B (2017) Relationship between vitamin D and gestational diabetes in overweight or obese pregnant women may be mediated by adiponectin. Mol Nutr Food Res 61:1700488. https://doi.org/10.1002/mnfr.201700488 CrossRef

125.

van Poppel MNM, Zeck W, Ulrich D, Schest E-C, Hirschmugl B, Lang U, Wadsack C, Desoye G (2014) Cord blood chemerin: differential effects of gestational diabetes mellitus and maternal obesity. Clin Endocrinol (Oxf) 80:65–72. https://doi.org/10.1111/cen.12140 CrossRef

126.

Vejrazkova D, Lischkova O, Vankova M, Stanicka S, Vrbikova J, Lukasova P, Vcelak J, Vacinova G, Bendlova B (2017) Distinct response of fat and gastrointestinal tissue to glucose in gestational diabetes mellitus and polycystic ovary syndrome. Physiol Res 66:283–292PubMed

127.

Zhang J, Chi H, Xiao H, Tian X, Wang Y, Yun X, Xu Y (2017) Interleukin 6 (IL-6) and tumor necrosis factor α (TNF-α) single nucleotide polymorphisms (SNPs), inflammation and metabolism in gestational diabetes mellitus in inner mongolia. Med Sci Monit 23:4149–4157CrossRef

128.

Zhang W, Zhao D, Meng Z, Wang H, Zhao K, Feng X, Li Y, Dun A, Jin X, Hou H (2018) Association between circulating visfatin and gestational diabetes mellitus: a systematic review and meta-analysis. Acta Diabetol. https://doi.org/10.1007/s00592-018-1188-x CrossRefPubMed

129.

Lobo TF, Torloni MR, Gueuvoghlanian-Silva BY, Mattar R, Daher S (2013) Resistin concentration and gestational diabetes: a systematic review of the literature. J Reprod Immunol 97:120–127. https://doi.org/10.1016/j.jri.2012.10.004 CrossRefPubMed

130.

Shostak A, Husse J, Oster H (2013) Circadian regulation of adipose function. Adipocyte 2:201–206. https://doi.org/10.4161/adip.26007 CrossRefPubMedPubMedCentral

131.

Mitchell EM, Lyles RH, Schisterman EF (2015) Positing, fitting, and selecting regression models for pooled biomarker data. Stat Med 34:2544–2558. https://doi.org/10.1002/sim.6496 CrossRefPubMedPubMedCentral

132.

Higgins JPT, Green S (2011) Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. In: The Cochrane Collaboration, 2011. https://handbook-5-1.cochrane.org/

Titel: Serum levels of adipokines in gestational diabetes: a systematic review
verfasst von: I. Bellos
G. Fitrou
V. Pergialiotis
D. N. Perrea
G. Daskalakis
Publikationsdatum: 01.06.2019
Verlag: Springer International Publishing
Erschienen in: Journal of Endocrinological Investigation / Ausgabe 6/2019
Elektronische ISSN: 1720-8386
DOI: https://doi.org/10.1007/s40618-018-0973-2

Cadmium exposure alters steroid receptors and proinflammatory cytokine levels in endothelial cells in vitro: a potential mechanism of endocrine disruptor atherogenic effect

Original Article

Maternal estradiol and progesterone concentrations among singleton spontaneous pregnancies during the first trimester

Original Article

Relevance of TSH evaluation in elderly in-patients with non-thyroidal illness

Original Article

Evaluating the effects of mobile health intervention on weight management, glycemic control and pregnancy outcomes in patients with gestational diabetes mellitus

Original Article

Tumor suppressor miR-145-5p sensitizes prolactinoma to bromocriptine by downregulating TPT1

Original Article

Risk of recurrence in patients with papillary thyroid carcinoma and minimal extrathyroidal extension not treated with radioiodine

Original Article

Kompaktes Leitlinien-Wissen Innere Medizin (Link öffnet in neuem Fenster)

Mit medbee Pocketcards schnell und sicher entscheiden.
Leitlinien-Wissen kostenlos und immer griffbereit auf ihrem Desktop, Handy oder Tablet.

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

Verbände und Cremes gegen Dekubitus: „Wir wissen nicht, was sie bringen!“

17.01.2025
Dekubitus
Nachrichten

Die Datenlage zur Wirksamkeit von Verbänden oder topischen Mitteln zur Prävention von Druckgeschwüren sei schlecht, so die Verfasser einer aktuellen Cochrane-Studie. Letztlich bleibe es unsicher, ob solche Maßnahmen den Betroffenen nutzen oder schaden.

Schützt das tägliche Glas Milch vor Darmkrebs?

17.01.2025
Kolorektales Karzinom
Nachrichten

Die Milch machts – sie bietet Frauen nach Daten einer großen Ernährungsanalyse den besten Darmkrebsschutz aller Lebensmittel, was am hohen Kalziumgehalt liegen dürfte. Am anderen Ende des Spektrums steht der Alkoholkonsum: Das Glas Wein am Abend ist eher ungünstig.

Vorsicht mit Glukokortikoiden bei Glomerulopathie

16.01.2025
Primäre Glomerulonephritiden
Nachrichten

Auch niedrig dosierte Glukokortikoide zur Behandlung einer primären Glomerulopathie lassen offenbar die Infektionsgefahr steigen. In einer US-Studie hing das Risiko vor allem mit der kombinierten Anwendung von Immunsuppressiva zusammen.

KI-gestütztes Mammografiescreening überzeugt im Praxistest

16.01.2025
Künstliche Intelligenz im Gesundheitswesen
Nachrichten

Mit dem Einsatz künstlicher Intelligenz lässt sich die Detektionsrate im Mammografiescreening offenbar deutlich steigern. Mehr unnötige Zusatzuntersuchungen sind laut der Studie aus Deutschland nicht zu befürchten.

EKG Essentials: EKG befunden mit System (Link öffnet in neuem Fenster)

In diesem CME-Kurs können Sie Ihr Wissen zur EKG-Befundung anhand von zwölf Video-Tutorials auffrischen und 10 CME-Punkte sammeln.
Praxisnah, relevant und mit vielen Tipps & Tricks vom Profi.

Jetzt 10 CME-Punkte sammeln

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Serum levels of adipokines in gestational diabetes: a systematic review

Abstract

Objective

Materials and methods

Results

Conclusions

Weitere Artikel der Ausgabe 6/2019

Cadmium exposure alters steroid receptors and proinflammatory cytokine levels in endothelial cells in vitro: a potential mechanism of endocrine disruptor atherogenic effect

Maternal estradiol and progesterone concentrations among singleton spontaneous pregnancies during the first trimester

Relevance of TSH evaluation in elderly in-patients with non-thyroidal illness

Evaluating the effects of mobile health intervention on weight management, glycemic control and pregnancy outcomes in patients with gestational diabetes mellitus

Tumor suppressor miR-145-5p sensitizes prolactinoma to bromocriptine by downregulating TPT1

Risk of recurrence in patients with papillary thyroid carcinoma and minimal extrathyroidal extension not treated with radioiodine

Kompaktes Leitlinien-Wissen Innere Medizin (Link öffnet in neuem Fenster)

Neu im Fachgebiet Innere Medizin

Verbände und Cremes gegen Dekubitus: „Wir wissen nicht, was sie bringen!“

Schützt das tägliche Glas Milch vor Darmkrebs?

Vorsicht mit Glukokortikoiden bei Glomerulopathie

KI-gestütztes Mammografiescreening überzeugt im Praxistest

EKG Essentials: EKG befunden mit System (Link öffnet in neuem Fenster)

Update Innere Medizin

Springer Medizin

Abstract

Objective

Materials and methods

Results

Conclusions

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten